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TYRA BIOSCIENCES INC

Tyra Biosciences

Tyra Biosciences Inc is a clinical-stage biotechnology company focused on developing next-generation precision medicines that target large opportunities in Fibroblast Growth Factor Receptor (FGFR) biology. The company's in-house precision medicine platform, SNAP, enables rapid and precise drug design through iterative molecular SNAPshots that help to design and predict which product candidates may demonstrate the highest potency, selectivity, and tolerability in the clinic. The various drug candidates in the company's product pipeline are TYRA-300, TYRA-200, and TYRA-430: three clinical-stage, novel small molecules designed to overcome the toxicity and resistance liabilities of first-generation pan-FGFR inhibitors.

Tyra Biosciences Inc

TYRANNA RESOURCES LTD by Tyranna Resources Ltd.

Tyranna Resources Ltd

DoorDash (NASDAQ:<a href="https://www.benzinga.com/quote/DASH"> DASH</a>) is synonymous with food delivery in the U.S., and now it appears the company is positioning itself to take on the European market.The delivery giant has <a href="https://ir.doordash.com/news/news-details/2025/DoorDash-Announces-Agreement-to-Acquire-Deliveroo/default.aspx">announced</a> it will acquire U.K.-based Deliveroo in a $3.9 billion deal. U.K.-based Deliveroo is like DoorDash in that it is one of the most recognizable names in its geographic market.&nbsp;
The deal, which <a href="https://www.reuters.com/markets/deals/doordash-acquire-uks-deliveroo-39-billion-deal-2025-05-06/">Reuters</a> says both sides have been working on for the last several months, is indicative of a changing landscape in the food delivery business. According to Reuters, the sector has been struggling due to several factors. First, inflation and increased costs have forced consumers to tighten their belts, and dialing back on luxuries like dinner delivery is an easy way to cut expenses. Second, there is an overabundance of competitors in the sector.
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The two obstacles to profit have created an environment where consolidation is much more likely. AJ Bell Investment Director Russ Mould told Reuters he believes the entire sector has been weakened by an oversaturation of delivery services competing for the same customers. That kind of climate inevitably means that some food-delivery services operating today will not survive the current downturn.
&#8220;Only the strongest will survive, and they&#8217;re the ones picking up smaller rivals who realize their future is [the] best part of a bigger entity, and not going it alone,&#8221; he said.&nbsp;
<a href="https://www.benzinga.com/general/restaurants/25/05/45400599/only-reasonable-profits-jdcom-takes-aim-at-global-food-delivery-economics-with-zero-commission-modelrevives-founders-035-principle">DoorDash</a> may have gotten a good deal on the final price. According to Reuters, Deliveroo shares are trading on the London Stock Exchange for less than half of their 2021<a href="https://www.benzinga.com/money/how-to-invest-in-upcoming-ipos"> IPO</a> price. Deliveroo CEO Will Shu, who delivered meals himself during the company's formative years, was philosophical about the current business climate and its effect on the company's share price.
Trending: Invest where it hurts — and help millions heal:<a href="https://www.benzinga.com/money/a-cure-for-osteoarthritis-powered-by-everyday-investors-cytonics-is-looking-to-beat-big-pharma-and-disrupt-a-390-billion-market"> Invest in Cytonics and help disrupt a $390B Big Pharma stronghold</a>.
&#8220;That was a different time, (and) a different interest rate environment," Shu told Reuters. He was optimistic about Deliveroo's long-term future, but also very aware of how much competition his company was facing. &#8220;The board and myself evaluated that and said, &#8216;Where do we think Deliveroo should be in order for us to truly win?&#8217; And we thought this was the right place for us,&#8221; he said.
Shu's analysis illustrates the reality of being a CEO of a company. You have a duty to your shareholders and investors to do what's best for the company, even if that means being acquired at a relative discount by a larger company. With that said, it's not all bad news for Shu. Reuters estimates that he will receive roughly $215 million for his Deliveroo shares.&nbsp;
"I could not be more excited by the prospect of what DoorDash and Deliveroo will be able to accomplish together," said <a href="https://ir.doordash.com/news/news-details/2025/DoorDash-Announces-Agreement-to-Acquire-Deliveroo/default.aspx">DoorDash CEO</a> Tony Xu. " We'll cover more than 40 countries with a combined population of more than 1 billion people, enabling us to provide more local businesses with the tools and technology they need to thrive." Reuters estimates the two companies did roughly $90 billion in delivery orders in 2024.
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Image: Shutterstock

News

Is DoorDash Planning To Gobble Up Europe? Company Strikes $3.9 Billion Deal To Buy UK Food Delivery Company Deliveroo

EKSO

Trading Halt: Halted at 7:50:00 p.m. ET - Trading Halt: Halt News Pending

LYEL

APDN

Cigna Group (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CI#NYSE">CI</a>) has outperformed the market over the past 15 years by 3.91% on an annualized basis producing an average annual return of 16.06%. Currently, Cigna Group has a market capitalization of $85.84 billion. 
Buying $100 In CI: If an investor had bought $100 of CI stock 15 years ago, it would be worth $929.38 today based on a price of $316.64 for CI at the time of writing.
<h3>Cigna Group's Performance Over Last 15 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1748648720_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Trading Ideas

Here's How Much $100 Invested In Cigna Group 15 Years Ago Would Be Worth Today

If you've ever assumed retirement meant having a seven-figure nest egg, you're in good company — and maybe a little stressed.
For years, Americans have treated the $1 million mark as the gold standard for retiring comfortably. Anything less? Cue the panic attacks.
But according to Northwestern Mutual's just-released <a href="https://news.northwesternmutual.com/planning-and-progress-study-2025">2025 Planning &amp; Progress Study</a>, the average American now believes they need $1.26 million tucked away to retire in peace. That's actually down from $1.46 million last year.
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</ul>
Sure, the so-called magic number dropped by $200,000, but don't pop the champagne just yet. According to the same study, most Americans are <a href="https://www.benzinga.com/personal-finance/25/02/43856927/billionaire-blackrock-ceo-larry-fink-says-people-are-saving-too-much-and-not-investing-enough-to-retire-with-dignity">still wildly unprepared</a>. More than half – 51% – say it's somewhat or very likely they'll outlive their savings. Only 16% feel confident that outliving their savings is "very unlikely."&nbsp;&nbsp;
So if your retirement plan is "hope for the best," you're not alone.
The ‘magic number' to retire comfortably may be down this year, but it's still far beyond what many people actually have. And the gap isn't just wide — it's a canyon.&nbsp;
<a href="https://institutional.vanguard.com/insights-and-research/report/how-america-saves.html?cmpgn=IIG:TL:HAS:HAS24:SRCH:PS:XX:TL:GG:Unknown:Phrase:TLEAD:20230615:BD:NONE:NONE:KW:401kGeneral&amp;gclsrc=aw.ds&amp;gad_source=1&amp;gad_campaignid=17413933089&amp;gbraid=0AAAAADyd_RXD2epePnTlHlLRHWErHyW3U">Vanguard's 2024 report</a> puts the average 401(k) balance across all age groups at just $134,128. That's barely a tenth of what Americans say they'll need to retire comfortably.
Trending: Maximize saving for your retirement and cut down on taxes: <a href="https://www.benzinga.com/money/wideradvisor-retirement-planning">Schedule your free call with a financial advisor to start your financial journey – no cost, no obligation</a>.&nbsp;
And what's behind the drop? Inflation is still top of mind, but it's cooled off—dropping from around 6% in 2023 to <a href="https://www.bls.gov/opub/ted/2025/the-consumer-price-index-rose-3-0-percent-from-january-2024-to-january-2025.htm">about 3% in 2024</a>. That doesn't mean prices are falling; it just means they're not rising quite as fast. Groceries still feel like a splurge and rent still makes you cry, but apparently, that slight dip was enough for Americans to shave down their expectations.
Either way, the new target still feels like a stretch. <a href="https://www.benzinga.com/money/smartasset">One in four Americans has just a single year of income saved</a>. Among Gen X'ers, 52% have saved up to three times their annual income, but&nbsp; 54% don't think they'll be financially ready to retire when the time comes.<a href="https://www.asppa-net.org/news/2025/4/magic-number-for-retirement-drops-with-inflation/">&nbsp;</a>
Which raises a fair question—not from a study or expert, just plain observation: Are Americans adjusting the number because they think they can genuinely live on less, or have they just accepted that $1.26 million sounds more reachable than $1.46 million? Maybe this is optimism. Maybe it's financial fatigue.&nbsp;
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If you're wondering how anyone hits that $1.26 million target: you either start young or start wealthy. To get there by age 65, a 20-year-old would need to sock away $330 a month at a 7% return. <a href="https://www.benzinga.com/personal-finance/24/08/40295808/youre-40-50-or-60-do-you-know-how-much-you-should-have-saved-for-retirement-by-now">Wait until you're 50? </a>That jumps to a casual $3,958 per month.<a href="https://www.asppa-net.org/news/2025/4/magic-number-for-retirement-drops-with-inflation/">&nbsp;</a>
Yes, the goal dipped—but the struggle to reach it hasn't. Americans may be adjusting expectations, but most still have a long way to go before <a href="https://www.benzinga.com/money/are-you-rich">retirement feels anything close to "comfortable."</a>
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Image: Shutterstock

Personal Finance

Can You Guess What Americans Think They Need To Retire Comfortably? Hint: The 'Magic Number' Just Dropped From Last Year

<ul class="wp-block-list">
<li>The U.S. Department of Health and Human Services says that around 57% of Americans will need long-term care at some point</li>
<li>Most households have grossly underestimated the potential cost of that long-term care, and aren't aware that they will have to pay out of pocket for much of it</li>
<li>The total cost of long-term care can be significant, extending beyond $100,000</li>
</ul>
Long-term care costs can be significant, extending well beyond $100,000, but experts tell <a href="https://www.cnbc.com/2025/05/17/why-long-term-care-costs-can-be-a-huge-problem.html">CNBC</a> that most households aren't prepared to handle the expense.
"People don't plan for it in advance," certified financial planner Carolyn McClanahan told the network. "It's a huge problem."
A 2022 <a href="https://www.urban.org/research/publication/long-term-services-and-supports-older-americans">report</a> by the U.S. Department of Health and Human Services and the Urban Institute says that 57% of Americans turning 65 will develop a disability that is serious enough to require long-term care. The average cost of this long-term care is $122,400, the report said.
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On average, families will pay for 37% of the total cost of this long-term care out of pocket, with the rest covered by insurance and public programs.&nbsp;
"It's pretty clear [workers] don't have that amount of savings in retirement, that amount of savings in their checking or savings accounts, and the majority don't have long-term care insurance," Employee Benefit Research Institute strategist Bridget Bearden told CNBC. "So where is the money going to come from?"
Costs for long-term care vary widely, depending on where you live. However, <a href="https://www.carescout.com/cost-of-care">data</a> collected by Genworth and CareScout put the national average for a home health aide at $6,483 per month and $5,900 for a spot in an assisted living facility.&nbsp;
Trending: Maximize saving for your retirement and cut down on taxes: <a href="https://www.benzinga.com/money/wideradvisor-retirement-planning">Schedule your free call with a financial advisor to start your financial journey – no cost, no obligation</a>.&nbsp;
Still, many people grossly underestimate how much long-term care could potentially cost them. A recent Employee Benefit Research Institute <a href="https://www.ebri.org/health/content/employee-perspectives-on-long-term-care">report</a> found that "a significant proportion of future caregivers had not estimated LTC costs," and those who had expected them to remain under $50,000. Additionally, the report found that 43% of future caregivers expected Medicare to cover the costs of long-term care, and 29% expected Medicaid to foot the bill.
Experts told CNBC that estimates like these are not realistic. Health insurance generally doesn't cover long-term care services, and Medicare only covers select aspects, they say.
McClanahan told CNBC that Medicare typically covers skilled care for up to 100 days, which covers things like rehab or medicine administration, but will not cover the custodial care required for daily activities like bathing and dressing.&nbsp;
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As for Medicaid, the largest payer of long-term care costs, not everyone will qualify. Most people who are eligible for these benefits come from low-income households. "You basically have to be destitute" for Medicaid to kick in, she said.
"The challenge with long-term care costs is they're unpredictable," McClanahan told CNBC. "You don't always know when you'll get sick and need care."&nbsp;
She advises Gen Xers and Millennials to begin planning for potential long-term care needs now. "When you think through it in advance, it keeps the decisions way more level-headed," she said.
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<li><a href="https://www.benzinga.com/money/gbr-savings-by-age">If You're Age 35, 50, or 60: Here&#8217;s How Much You Should Have Saved Vs. Invested By Now</a></li>
<li>‘Scrolling To UBI' — Deloitte's #1 fastest-growing software company allows users to earn money on their phones. <a href="https://www.benzinga.com/money/mode-mobile-2">You can invest today for just $0.30/share with a $1000 minimum.</a></li>
</ul>
Image: Shutterstock

'It's A Huge Problem,' Experts Urge Gen Xers And Millennials To Plan For Long-Term Care

Intuitive Surgical (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ISRG#NASDAQ">ISRG</a>) has outperformed the market over the past 5 years by 9.52% on an annualized basis producing an average annual return of 23.37%. Currently, Intuitive Surgical has a market capitalization of $197.97 billion. 
Buying $100 In ISRG: If an investor had bought $100 of ISRG stock 5 years ago, it would be worth $288.38 today based on a price of $552.34 for ISRG at the time of writing.
<h3>Intuitive Surgical's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1748647811_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

ISRG

$100 Invested In Intuitive Surgical 5 Years Ago Would Be Worth This Much Today

NVIDIA (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVDA#NASDAQ">NVDA</a>) has outperformed the market over the past 15 years by 38.55% on an annualized basis producing an average annual return of 50.71%. Currently, NVIDIA has a market capitalization of $3.29 trillion. 
Buying $100 In NVDA: If an investor had bought $100 of NVDA stock 15 years ago, it would be worth $44,689.54 today based on a price of $134.77 for NVDA at the time of writing.
<h3>NVIDIA's Performance Over Last 15 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1748646912_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

NVDA

If You Invested $100 In This Stock 15 Years Ago, You Would Have This Much Today

Comfort Systems USA (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/FIX#NYSE">FIX</a>) has outperformed the market over the past 5 years by 51.3% on an annualized basis producing an average annual return of 65.16%. Currently, Comfort Systems USA has a market capitalization of $16.87 billion. 
Buying $100 In FIX: If an investor had bought $100 of FIX stock 5 years ago, it would be worth $1,256.85 today based on a price of $478.23 for FIX at the time of writing.
<h3>Comfort Systems USA's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1748646010_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Here's How Much $100 Invested In Comfort Systems USA 5 Years Ago Would Be Worth Today

IES Hldgs (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IESC#NASDAQ">IESC</a>) has outperformed the market over the past 5 years by 47.83% on an annualized basis producing an average annual return of 61.68%. Currently, IES Hldgs has a market capitalization of $5.16 billion. 
Buying $100 In IESC: If an investor had bought $100 of IESC stock 5 years ago, it would be worth $1,103.53 today based on a price of $259.66 for IESC at the time of writing.
<h3>IES Hldgs's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1748645112_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

IESC

$100 Invested In IES Hldgs 5 Years Ago Would Be Worth This Much Today

STLD

UPDATE: President Donald Trump Says He Would Be Increasing Tariffs On Steel To 50% From 25%; Tariffs To Go Into Effect Next Week

<a href="https://www.youtube.com/watch?v=xqnyP6mUI7w">https://www.youtube.com/watch?v=xqnyP6mUI7w</a>

General

President Trump Says U.S. Steel Will Be Controlled By USA; Says Steel Tariffs Go Into Effect Next Week

<a href="https://www.bloomberg.com/news/articles/2025-05-30/trump-to-raise-steel-tariffs-to-50-to-help-nippon-us-steel-deal?embedded-checkout=true" title="https://www.bloomberg.com/news/articles/2025-05-30/trump-to-raise-steel-tariffs-to-50-to-help-nippon-us-steel-deal?embedded-checkout=true">https://www.bloomberg.com/news/articles/2025-05-30/trump-to-raise-steel-tariffs-to-50-to-help-nippon-us-steel-deal?embedded-checkout=true</a>

'Trump to Raise Steel Tariffs to 50% to Help Nippon-US Steel Deal'- Bloomberg

In the current market session, Principal Financial Group Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PFG#NASDAQ">PFG</a>) share price is at $77.89, after a 0.84% drop. Over the past month, the stock spiked by 1.38%, but over the past year, it actually fell by 3.53%. With good short-term performance like this, and questionable long-term performance, long-term shareholders might want to start looking into the company's price-to-earnings ratio.

<img src="https://www.benzinga.com/files/images/story/2025/1748642422_0.png" alt="Past Year Chart" />

<h3>Principal Financial Group P/E Compared to Competitors</h3>
The P/E ratio is used by long-term shareholders to assess the company's market performance against aggregate market data, historical earnings, and the industry at large. A lower P/E could indicate that shareholders do not expect the stock to perform better in the future or it could mean that the company is undervalued. 
Principal Financial Group has a better P/E ratio of 16.82 than the aggregate P/E ratio of 13.53 of the Insurance industry. Ideally, one might believe that Principal Financial Group Inc. might perform better in the future than it's industry group, but it's probable that the stock is overvalued. 

<img src="https://www.benzinga.com/files/images/story/2025/1748642422_1.png" alt="Guage" />

In conclusion, the price-to-earnings ratio is a useful metric for analyzing a company's market performance, but it has its limitations. While a lower P/E can indicate that a company is undervalued, it can also suggest that shareholders do not expect future growth. Additionally, the P/E ratio should not be used in isolation, as other factors such as industry trends and business cycles can also impact a company's stock price. Therefore, investors should use the P/E ratio in conjunction with other financial metrics and qualitative analysis to make informed investment decisions.

Intraday Update

Markets

Price Over Earnings Overview: Principal Financial Group

Constellation Brands (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/STZ#NYSE">STZ</a>) has outperformed the market over the past 20 years by 1.42% on an annualized basis producing an average annual return of 9.7%. Currently, Constellation Brands has a market capitalization of $31.79 billion. 
Buying $100 In STZ: If an investor had bought $100 of STZ stock 20 years ago, it would be worth $634.94 today based on a price of $178.58 for STZ at the time of writing.
<h3>Constellation Brands's Performance Over Last 20 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1748642418_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

$100 Invested In This Stock 20 Years Ago Would Be Worth This Much Today

<a href="https://www.bloomberg.com/news/articles/2025-05-30/trump-officials-set-for-talks-with-asia-leaders-on-alaska-energy?embedded-checkout=true">https://www.bloomberg.com/news/articles/2025-05-30/trump-officials-set-for-talks-with-asia-leaders-on-alaska-energy?embedded-checkout=true</a>

'Trump Officials Set for Talks With Asia Leaders on Alaska Energy'- Bloomberg

SBET

SharpLink Gaming Files For Mixed Shelf Offering; Size Not Disclosed

CELU

Celularity Receives Nasdaq Letter Regarding Form 10-Q

Salesforce (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CRM#NYSE">CRM</a>) has outperformed the market over the past 15 years by 5.91% on an annualized basis producing an average annual return of 18.07%. Currently, Salesforce has a market capitalization of $253.42 billion. 
Buying $1000 In CRM: If an investor had bought $1000 of CRM stock 15 years ago, it would be worth $11,841.59 today based on a price of $265.08 for CRM at the time of writing.
<h3>Salesforce's Performance Over Last 15 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1748640629_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

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