Bulls vs Bears
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Market sentiment signals for Spyre Therapeutics (SYRE): analyst consensus, short interest, options flow and insider activity.
Analyst Consensus
Buy
20 analysts
Options Flow (P/C)
0.00
More calls — Bullish
Avg Consensus PT
$101
+6.5%
Highest Price Target
$130
+37.3%
Lowest Price Target
$44
-53.5%
Short Interest
14.6%
Declining — Bullish
Insider Activity (30d)
Net Seller
Short Interest — % of Float
| Date | Firm | Analyst & Accuracy | Upside / Downside | PT Change | Action | Rating |
|---|---|---|---|---|---|---|
| Oct 19, 2026 | BTIG | Julian Harrison— | +27.8% | $121 → $121 | Maintained | Buy |
| Oct 12, 2026 | UBS | Alice Nettleton— | +26.7% | $120 | Initiate | Buy |