Spyre Therapeutics Market Sentiment

Spyre Therapeutics Inc

SYRENASDAQ

Trade with Public

$107.36

0.710.67%

al cierre: Aug 25, 5:00 PM EST

$99.00

-8.36-7.79%

After hour: 7:29 PM EST

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¿Por qué se mueve?:Spyre Therapeutics shares are trading lower after the company announced top...

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Spyre Therapeutics Market Sentiment

Market sentiment signals for Spyre Therapeutics (SYRE): analyst consensus, short interest, options flow and insider activity.

Key Signals

Analyst Consensus▲ Buy

Short Interest▲ 15.1% short float

Options Flow— N/A

Insider Activity▼ Net Seller (30d)

Analyst Consensus

Buy

18 analysts

Options Flow (P/C)

—

0 calls · 75 puts

Avg Consensus PT

$101

+1.7%

Highest Price Target

$135

+36.4%

Deutsche Bank

Lowest Price Target

$44

-55.6%

Guggenheim

Short Interest

15.1%

Declining — Bullish

Insider Activity (30d)

Net Seller

Short Interest — % of Float

Recent Analyst Actions

Date	Firm	Analyst & Accuracy	Upside / Downside	PT Change	Action	Rating
Aug 11, 2026	BTIG	Julian Harrison—	+33.3%	$112 → $132	Maintained	Buy
Aug 5, 2026	Wells Fargo	Yanan Zhu—	+16.2%	$90 → $115	Maintained	Overweight
Aug 5, 2026	Guggenheim	Yatin Suneja—	+31.3%	$115 → $130	Maintained	Buy
Aug 5, 2026	Wedbush	David Nierengarten—	+31.3%	$100 → $130	Maintained	Outperform
Jul 28, 2026	Wolfe Research	Andy Chen—	—	—	Downgrade	Outperform→Peer Perform
Jul 13, 2026	Mizuho	Joseph Catanzaro—	+21.2%	$84 → $120	Maintained	Outperform
Jun 23, 2026	Deutsche Bank	David Hoang—	+36.4%	$115 → $135	Maintained	Buy
Jun 15, 2026	BTIG	Julian Harrison—	+13.1%	$98 → $112	Maintained	Buy
Jun 4, 2026	Deutsche Bank	David Hoang—	+16.2%	$102 → $115	Maintained	Buy
May 6, 2026	Citigroup	Samantha Semenkow—	-2.0%	$64 → $97	Maintained	Buy
May 6, 2026	Stifel	Alex Thompson—	+8.1%	$92 → $107	Maintained	Buy
Apr 17, 2026	Jones Trading	Debanjana Chatterjee—	-4.0%	$64 → $95	Maintained	Buy
Apr 14, 2026	Wells Fargo	Yanan Zhu—	-9.1%	$50 → $90	Maintained	Overweight
Apr 14, 2026	Wedbush	David Nierengarten—	-19.2%	$65 → $80	Maintained	Outperform
Apr 14, 2026	Baird	Colleen Kusy—	-9.1%	$65 → $90	Maintained	Outperform
Apr 14, 2026	Raymond James	Martin Auster—	-19.2%	$80	Initiate	Strong Buy
Apr 14, 2026	Deutsche Bank	David Hoang—	-11.1%	$55 → $88	Maintained	Buy
Apr 13, 2026	Leerink Partners	Thomas Smith—	+7.1%	$49 → $106	Maintained	Outperform
Apr 13, 2026	Jefferies	Akash Tewari—	-14.1%	$47 → $85	Maintained	Buy
Apr 13, 2026	BTIG	Julian Harrison—	-1.0%	$70 → $98	Maintained	Buy
Mar 31, 2026	BTIG	Julian Harrison—	-29.3%	$70 → $70	Maintained	Buy
Mar 18, 2026	Stifel	Alex Thompson—	-7.1%	$70 → $92	Maintained	Buy
Mar 16, 2026	BTIG	Julian Harrison—	-29.3%	$70 → $70	Maintained	Buy
Feb 20, 2026	Wells Fargo	Yanan Zhu—	-49.5%	$40 → $50	Maintained	Overweight
Feb 20, 2026	BTIG	Julian Harrison—	-29.3%	$70 → $70	Maintained	Buy