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ONESTREAM INC

OneStream

OneStream Inc is an AI-enabled and extensible software platform that unifies core financial functions and broader operational data and processes within a single platform. The Digital Finance Cloud of the company provides a comprehensive, dynamic, and predictive view of the entire enterprise, providing corporate leaders the control, visibility, and agility required to proactively adjust business and day-to-day execution. Company platform unifies core financial and operational data and processes within a single platform, with solutions that maintain the integrity of corporate reporting standards for Finance while providing operationally insights for business users.

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Wedbush analyst Laura Chico downgrades Vigil Neuroscience (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VIGL#NASDAQ">VIGL</a>) from Outperform to Neutral and lowers the price target from $13 to $8.

News

Downgrades

Price Target

Analyst Ratings

VIGL

Wedbush Downgrades Vigil Neuroscience to Neutral, Lowers Price Target to $8

The most oversold stocks in the energy sector presents an opportunity to buy into undervalued companies.
The RSI is a momentum indicator, which compares a stock&#8217;s strength on days when prices go up to its strength on days when prices go down. When compared to a stock&#8217;s price action, it can give traders a better sense of how a stock may perform in the short term. An asset is typically considered oversold when the <a href="https://www.benzinga.com/topic/rsi">RSI is below 30</a>, according to <a href="https://pro.benzinga.com/">Benzinga Pro</a>.
Here's the latest list of major oversold players in this sector, having an RSI near or below 30.
<h3 class="wp-block-heading">FLEX LNG Ltd (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/FLNG#NYSE">FLNG</a>)</h3>
<ul class="wp-block-list">
<li>On May 21, Flex LNG posted better-than-expected quarterly earnings. Marius Foss, Interim CEO of Flex LNG Management AS, said, &#8220;Flex LNG delivered solid results for the first quarter, with revenues of $88.4 million, or $86.8 million excluding EUAs. Net income came in at $18.7 million, translating to earnings per share (EPS) of $0.35 and adjusted net income came in at $29.4 million, or $0.54 per share. As expected, revenue decreased by $3 million compared to Q4 2024 primarily due to lower earnings from Flex Artemis, operating on a variable index hire.&#8221; The company's stock fell around 9% over the past five days and has a 52-week low of $19.46.</li>
<li>RSI Value: 27.9</li>
<li>FLNG Price Action: Shares of FLEX LNG fell 8.2% to close at $22.39 on Wednesday.</li>
<li>Edge Stock Ratings: 24.66 Momentum score with Value at 71.53. </li>
</ul>
<figure class="wp-block-image size-full is-resized"><a href="https://www.benzinga.com/quote/FLNG"><img loading="lazy" decoding="async" width="486" height="183" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/05/22044048/image-277.png" alt="" class="wp-image-924003" style="width:316px;height:auto" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/05/22044048/image-277.png 486w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/05/22044048/image-277-300x113.png 300w" sizes="(max-width: 486px) 100vw, 486px" /></a></figure>
<h3 class="wp-block-heading">Helmerich and Payne Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HP#NYSE">HP</a>)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</h3>
<ul class="wp-block-list">
<li>On May 19, Citigroup analyst Scott Gruber downgraded Helmerich &amp; Payne from Buy to Neutral and lowered the price target from $25 to $19. The company's stock fell around 23% over the past month and <a href="https://www.benzinga.com/quote/HP">has a 52-week low</a> of $15.21.</li>
<li>RSI Value: 23.1</li>
<li>HP Price Action: Shares of Helmerich and Payne fell 5.6% to close at $15.21 on Wednesday.</li>
<li>Benzinga Pro&#8217;s charting tool helped identify the trend in <a href="https://www.benzinga.com/pro/register?utm_adType=bzprocontent&amp;utm_campaign=14daytrial&amp;utm_ad=0522">HP stock</a>. </li>
</ul>
<figure class="wp-block-image size-full is-resized"><a href="https://www.benzinga.com/pro/register?utm_adType=bzprocontent&amp;utm_campaign=14daytrial&amp;utm_ad=0522"><img loading="lazy" decoding="async" width="927" height="842" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/05/22044147/image-278.png" alt="" class="wp-image-924007" style="width:622px;height:auto" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/05/22044147/image-278.png 927w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/05/22044147/image-278-300x272.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/05/22044147/image-278-768x698.png 768w" sizes="(max-width: 927px) 100vw, 927px" /></a></figure>
<h3 class="wp-block-heading">Ring Energy Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/REI#NYSE">REI</a>)</h3>
<ul class="wp-block-list">
<li>On May 7, Ring Energy posted weaker-than-expected quarterly earnings. Mr. Paul D. McKinney, Chairman of the Board and Chief Executive Officer, commented, &#8220;We&#8217;re excited to kick off 2025 with a strong first quarter, showcasing the flexibility, resilience, and strength of our proven, value-focused strategy amid fluctuating oil prices. Our performance met or surpassed all guidance targets, driven by exceptional oil sales volumes.&#8221; The company's stock fell around 15% over the past five days and has a 52-week<a href="https://www.benzinga.com/quote/REI"> low of $0.74</a>.</li>
<li>RSI Value: 29.9</li>
<li>REI Price Action: Shares of Ring Energy fell 4.2% to close at $0.75 on Wednesday.</li>
<li>Benzinga Pro&#8217;s signals feature notified of a potential breakout in<a href="https://www.benzinga.com/pro/register?utm_adType=bzprocontent&amp;utm_campaign=14daytrial&amp;utm_ad=0522"> REI shares</a>.</li>
</ul>
How do other stocks rank? Get the full <a href="https://www.benzinga.com/premium/ideas/benzinga-edge-2#:~:text=Turn%20Market%20Chaos,when%20markets%20rebound">BZ Edge Rankings breakdown here</a>.
Read This Next:
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<li> <a href="https://www.benzinga.com/25/05/45540545/jim-cramer-recommends-not-buying-mosaic-doesnt-like-this-industrial-stock">Jim Cramer Recommends Not Buying Mosaic, Doesn&#8217;t Like This Industrial Stock</a> </li>
</ul>
Photo via Shutterstock

Long Ideas

Pre-Market Outlook

Markets

Trading Ideas

FLNG

Top 3 Energy Stocks That Could Lead To Your Biggest Gains This Quarter

Crypto markets are surging on early Thursday, with Bitcoin hitting a new all-time high above $110,000 amid accelerating institutional adoption and robust ETF inflows.
<figure class="wp-block-table"> 
<table class="has-fixed-layout">
<tbody>
<tr>
<td>Cryptocurrency</td>
<td>Price&nbsp;&nbsp;&nbsp;</td>
<td>Gains +/-</td>
</tr>
<tr>
<td>Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>)</td>
<td>$110,681.06</td>
<td>+4%</td>
</tr>
<tr>
<td>Ethereum (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/eth/usd">ETH</a>)</td>
<td>$2,650.22</td>
<td>+4.3%</td>
</tr>
<tr>
<td>Solana (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/sol/usd">SOL</a>)</td>
<td>$178.1</td>
<td>+5.3%</td>
</tr>
<tr>
<td>XRP (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/xrp/usd">XRP</a>)</td>
<td>$2.41</td>
<td>+2.7%</td>
</tr>
<tr>
<td>Dogecoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/doge/usd">DOGE</a>)</td>
<td>$0.2395</td>
<td>+5.6%</td>
</tr>
<tr>
<td>Shiba Inu (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/shib/usd">SHIB</a>)</td>
<td>$0.00001523</td>
<td>+4.9%</td>
</tr>
</tbody>
</table>
</figure>
Notable Statistics:
<ul class="wp-block-list">
<li>IntoTheBlock data shows Bitcoin and Ethereum large transaction increased by 22.1% and 36.9%, respectively, while BTC's daily active addresses went up by 7.7% and exchange netflows are up by 332.7%.</li>
<li>Coinglass data shows 125,650 traders were liquidated in the past 24 hours for $505.49 million.</li>
<li>SoSoValue data shows $608.99 million in net inflows into spot Bitcoin ETFs and $587,000 in net inflows into spot Ethereum ETFs.</li>
<li>CoinGlass data <a href="https://x.com/coinglass_com/status/1925449040130711574">shows</a> selling pressure for Bitcoin with nearly $200 million in stacked sell orders between $111,000–$113,200, with ~$8 million per $100 increment totalling around $200 million in cumulative sell pressure.</li>
<li><a href="https://x.com/coinbureau/status/1925463469714817335">According</a> to Coin Bureau, retail investors have yet to fully enter the market as wallets holding less than 1 BTC (&#8220;shrimp&#8221; addresses) remain lower than in May 2024 and January 2021. Once retail floods in, sentiment could turn euphoric.</li>
</ul>
Trader Notes: Glassnode data <a href="https://x.com/glassnode/status/1925484339002745285">reports</a> only $1 billion in profit-taking at Bitcoin's new all-time high, less than half the $2.1 billion seen when Bitcoin first crossed $100,000 in December. This suggests investors are holding tight for more upside.
Crypto trader Jelle sees Bitcoin having a target of $180,000 while Trader Tardigrade says Bitcoin broke out of a key battleground between bulls and bears and the bulls are now fully in charge and have emerged victorious.
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
<div class="wp-block-embed__wrapper">
<blockquote class="twitter-tweet" data-width="500" data-dnt="true"><a href="https://twitter.com/hashtag/Bitcoin?src=hash&amp;ref_src=twsrc%5Etfw">#Bitcoin</a> was caught in a tug-of-war between Bulls and Bears along the Bull/Bear Battle Line. Ultimately, the Bulls emerged victorious &#x1f525; Bulls now have full control of <a href="https://twitter.com/search?q=%24BTC&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$BTC</a> &#x1f680; <a href="https://t.co/g7mF1CntMT">pic.twitter.com/g7mF1CntMT</a>
&mdash; Trader Tardigrade (@TATrader_Alan) <a href="https://twitter.com/TATrader_Alan/status/1925495872613490726?ref_src=twsrc%5Etfw">May 22, 2025</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
</figure>
Dogecoin is breaking out of a bull pennant, with Ali Martinez targeting $0.31.
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
<div class="wp-block-embed__wrapper">
<blockquote class="twitter-tweet" data-width="500" data-dnt="true"><a href="https://twitter.com/hashtag/Dogecoin?src=hash&amp;ref_src=twsrc%5Etfw">#Dogecoin</a> <a href="https://twitter.com/search?q=%24DOGE&amp;src=ctag&amp;ref_src=twsrc%5Etfw">$DOGE</a> appears to be breaking out of a bull pennant, which suggests a target of $0.31! <a href="https://t.co/Hbzuwd7Akk">pic.twitter.com/Hbzuwd7Akk</a>
&mdash; Ali (@ali_charts) <a href="https://twitter.com/ali_charts/status/1925349892714615046?ref_src=twsrc%5Etfw">May 22, 2025</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
</figure>
Jelle <a href="https://x.com/CryptoJelleNL/status/1925477625474044354">remains </a>confident in his Solana holdings, expecting a strong rally once it clears $250. He expects a surge to $400–$500 once it clears resistance, as &#8220;weak hands&#8221; have already been flushed out.
Ethereum is holding strong, but Jelle <a href="https://x.com/CryptoJelleNL/status/1925482983965802725">believes</a> the real rally begins once it reclaims $3,000, which could trigger a broader market wave.
Read Next: 
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/markets/cryptocurrency/25/05/45541858/germany-sold-50000-bitcoin-below-60000-heres-how-much-it-missed-out-on">Germany Sold 50,000 Bitcoin Below $60,000: Here&#8217;s How Much It Missed Out On</a></li>
</ul>
Image: Shutterstock

Coverage of Bitcoin, Etherum, Ripple and all the latest digital currencies.

Cryptocurrency

$BTC

$DOGE

$ETH

$SHIB

$SOL

$XRP

Bitcoin Shatters $110,000, XRP, Dogecoin, Ethereum Surge: 'Bulls Emerge Victorious,' Trader Concludes

OSR Holdings, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/OSRH#NASDAQ">OSRH</a>), a public company dedicated to advancing innovation in healthcare and wellness, announced today that it has entered into a Memorandum of Understanding (MOU) with BCM Europe AG, its major shareholder, and Taekwondo Cooperative (TKD Coop), a global Taekwondo community organization, to explore the joint development of a security token, provisionally named the "OSRH Token". The initiative aims to enhance access to crypto-based liquidity and&nbsp;provide a basis for OSRH to launch crypto treasury strategies.

OSRH

OSR Holdings Enters Into MOU With BCM Europe And Taekwondo To Explore Joint Development Of Security Token, Provisionally Named "OSRH Token"

Barclays analyst David Strauss initiates coverage on Intuitive Machines (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LUNR#NASDAQ">LUNR</a>) with a Equal-Weight rating and announces Price Target of $13.

Initiation

LUNR

Barclays Initiates Coverage On Intuitive Machines with Equal-Weight Rating, Announces Price Target of $13

Needham analyst Gerald Pascarelli initiates coverage on Philip Morris Intl (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PM#NYSE">PM</a>) with a Buy rating and announces Price Target of $195.

Needham Initiates Coverage On Philip Morris Intl with Buy Rating, Announces Price Target of $195

GBIO

GIBO Introduces AIARSE: AI-Powered Asset Recognition Engine To Monetize Creator Contributions And Enforce IP Rights

Digi Power X Inc. ("Digi Power X" or the "Company") (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DGXX#NASDAQ">DGXX</a>, TSXV:<a class="ticker" href="https://www.benzinga.com/stock/DGX#TSXV">DGX</a>), a vertically integrated power infrastructure company focused on developing cutting-edge data centers for high-performance computing, is pleased to announce that US Data Centers, Inc., a wholly owned subsidiary of the Company, has entered into a collaboration with Super Micro Computer, Inc. (NASDAQ:<a href="https://www.benzinga.com/stock/SMCI#NASDAQ">SMCI</a>) to deploy customized B200 GPU rack solutions at the Company's newly developed data center in Alabama.
The collaboration will begin with an initial deployment targeting operational readiness within 120 days, with full test operations expected during Q4 2025. This project lays the foundation for a broader expansion at the Alabama site, with plans to scale up to 22 megawatts (MW) in 2026 and 55MW by 2027.

DGXX

SMCI

TSXV:DGX

Digi Power X's US Data Centers Collaborates With Super Micro Computer To Deploy Customized B200 GPU Rack Solutions At Newly Developed Data Center In Alabama

Contracts

Redwire Lands Avionics Contract For ESA's NGGM, Supporting MAGIC's Mission To Monitor Sea Level Rise And Ice Melt

Needham analyst Gerald Pascarelli initiates coverage on Altria Group (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MO#NYSE">MO</a>) with a Hold rating.

Needham Initiates Coverage On Altria Group with Hold Rating

SLNH

Soluna Signs Term Sheet For 75 MW Data Center

Barclays analyst Lydia Rainforth downgrades Equinor (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EQNR#NYSE">EQNR</a>) from Overweight to Equal-Weight.

EQNR

Barclays Downgrades Equinor to Equal-Weight

QNRX

Quoin Pharmaceuticals Receives FDA Clearance To Initiate Second Pivotal Whole Body QRX003 Netherton Syndrome Clinical Study

Honeywell International Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HON#NASDAQ">HON</a>) on Thursday disclosed that it will acquire Johnson Matthey&#8216;s Catalyst Technologies division in an all-cash deal valued <a href="https://www.benzinga.com/pressreleases/25/05/n45557790/honeywell-to-acquire-johnson-mattheys-catalyst-technologies-business-expanding-portfolio-of-leadin" target="_blank" rel="noreferrer noopener">at 1.8 billion pounds ($2.4 billion)</a>.
The purchase price represents roughly 11 times the projected 2025 EBITDA, factoring in tax advantages and anticipated cost synergies.
By integrating Catalyst Technologies with Honeywell&#8217;s Energy and Sustainability Solutions (ESS) segment, the company expects to enhance its portfolio with promising high-growth opportunities and realize substantial additional cost efficiencies.
Also Read: <a href="https://www.benzinga.com/25/03/44109915/honeywell-acquires-sundyne-for-216-billion-expanding-energy-and-industrial-equipment-portfolio" target="_blank" rel="noreferrer noopener">Honeywell Acquires Sundyne For $2.16 Billion, Expands Energy And Industrial Equipment Portfolio</a>
The company said that Johnson Matthey&#8217;s Catalyst Technologies business aligns well with Honeywell&#8217;s existing UOP operations, which focus on catalysts and process technologies and will broaden Honeywell&#8217;s footprint in the refining and petrochemical catalyst markets.
This acquisition also enables Honeywell, for the first time, to deliver an end-to-end solution for producing lower-emission, essential fuels such as sustainable methanol, sustainable aviation fuel (SAF), blue hydrogen, and blue ammonia, contributing to both energy security and emissions reduction.
The expanded offerings will include licensed technologies, engineering expertise, support services, and catalysts for transforming hydrocarbon and renewable feedstocks into high-value products.
The transaction is expected to be completed by the first half of 2026, pending standard closing conditions and regulatory approvals.
The acquisition is anticipated to contribute positively to earnings within the first year and is expected to introduce high-growth opportunities to Honeywell&#8217;s Energy and <a href="https://www.benzinga.com/calendars/guidance" target="_blank" rel="noreferrer noopener">Sustainability Solutions (ESS) division</a>.
This move follows Honeywell&#8217;s recently announced plans to spin off its Aerospace Technologies <a target="_blank" href="https://www.benzinga.com/news/asset-sales/24/12/42505835/honeywell-advances-strategic-review-explores-aerospace-business-separation" rel="noreferrer noopener">and Advanced Materials businesses</a>.
These separations will result in three independent, publicly traded companies with a focused strategy and distinct growth drivers.
Also, the company remains on track to surpass its goal of allocating at least $25 billion through 2025 across high-return investments, dividend payments, selective share <a target="_blank" href="https://www.benzinga.com/calendars/guidance" rel="noreferrer noopener">repurchases, and strategic acquisitions</a>.
In April, the company&nbsp;reported&nbsp;first-quarter revenue&nbsp;of&nbsp;$9.82 billion, beating the consensus of&nbsp;$9.59 billion, and adjusted EPS was&nbsp;$2.51 (+7% Y/Y),&nbsp;<a target="_blank" href="https://www.benzinga.com/25/04/45066884/honeywell-q1-strong-growth-in-aerospace-offsets-industrial-dip-narrows-outlook-amid-uncertain-demand-scenario" rel="noreferrer noopener">beating the consensus of&nbsp;$2.21</a>.
Honeywell held cash and equivalents of about&nbsp;$9.66 billion as of March 31, 2025.
Investors can gain exposure to the stock via Themes Transatlantic Defense ETF (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NATO#NASDAQ">NATO</a>) and Gabelli Commercial Aerospace and Defense ETF (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GCAD#NYSE">GCAD</a>).
Price Action: HON shares are trading higher by 0.13% to $222.17 at last check Thursday.
Read Next:
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/news/earnings/earnings-beats/25/04/45109933/honeywell-international-posts-q1-beat-heres-what-could-affect-performance-in-h2-analyst-raises-price-target" target="_blank" rel="noreferrer noopener">Honeywell International Posts Q1 Beat: Here&#8217;s What Could Affect Performance In H2, Analyst Raises Price Target</a></li>
</ul>
Image via Shutterstock

Equities

Large Cap

GCAD

NATO

Honeywell Deepens Renewable Fuels Push With $2.4 Billion Deal

JP Morgan analyst Ryan Brinkman reinstates Goodyear Tire &amp; Rubber (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GT#NASDAQ">GT</a>) with a Overweight and lowers the price target from $18 to $17.

JP Morgan Reinstates Overweight on Goodyear Tire & Rubber, Lowers Price Target to $17

HC Wainwright &amp; Co. analyst Emily Bodnar assumes RAPT Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RAPT#NASDAQ">RAPT</a>) with a Buy rating and announces Price Target of $6.

RAPT

HC Wainwright & Co. Assumes RAPT Therapeutics at Buy, Announces Price Target of $6

Needham analyst Mayank Tandon maintains Ncino (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NCNO#NASDAQ">NCNO</a>) with a Buy and raises the price target from $28 to $33.

NCNO

Needham Maintains Buy on Ncino, Raises Price Target to $33

Vigil Neuroscience, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VIGL#NASDAQ">VIGL</a>) on Wednesday disclosed that it entered a deal to be acquired by Sanofi (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SNY#NASDAQ">SNY</a>) for&nbsp;an equity value of approximately <a target="_blank" href="https://www.benzinga.com/pressreleases/25/05/g45555759/vigil-neuroscience-enters-into-definitive-merger-agreement-to-be-acquired-by-sanofi" rel="noreferrer noopener">$470 million (on a fully diluted basis)</a>.
Per the terms, Sanofi will pay $8.00 per share in cash to acquire Vigil. In addition, shareholders will be granted a non-tradeable contingent value right (CVR), which could provide an extra $2.00 per share in cash if VG-3927 achieves its first commercial sale <a target="_blank" href="https://www.benzinga.com/pressreleases/25/05/g45555705/press-release-sanofi-to-acquire-vigil-neuroscience-inc-adding-a-new-investigational-medicine-to-tr" rel="noreferrer noopener">within a designated timeframe</a>.
The total equity value of the transaction, including the potential CVR payment, represents approximately $600 million on a fully diluted basis.
Also Read: <a target="_blank" href="https://www.benzinga.com/25/01/43167375/vigil-neurosciences-alzheimers-candidate-shows-encouraging-safety-profile-plans-to-start-mid-stage-study-in-q3" rel="noreferrer noopener">Vigil Neuroscience&#8217;s Alzheimer&#8217;s Candidate Shows Encouraging Safety Profile, Plans To Start Mid-Stage Study In Q3</a>
This acquisition, expected to close in the third quarter of 2025, strengthens Sanofi&#8217;s neurology pipeline with VG-3927, an oral TREM2 agonist for Alzheimer&#8217;s disease, addressing a critical unmet need in treatment.
Ivana Magovčević-Liebisch, Ph.D., J.D., President and CEO of Vigil, said, &#8220;Sanofi&#8217;s development capabilities, therapeutic expertise, global footprint, and financial strength provide the greatest opportunity to further the development of VG-3927 for the potential treatment of Alzheimer&#8217;s disease and potentially bring this important and differentiated therapy to those struggling with the immense burden of this disease.&#8221;
Houman Ashrafian, M.D., Ph.D., Head of Research and Development of Sanofi, added, &#8220;TREM2 represents a compelling target at the intersection of immune dysregulation and neurodegeneration, particularly in people living with Alzheimer&#8217;s because they face devastating cognitive decline with limited treatment options.&#8221;
In April 2025, Vigil Neuroscience presented new data from its oral small molecule program, featuring its lead candidate, VG-3927, through two oral presentations at the AD/PD 2025 <a target="_blank" href="https://www.benzinga.com/pressreleases/25/04/g44603290/vigil-neuroscience-presents-data-on-its-small-molecule-trem2-agonist-vg-3927-in-two-oral-presentat" rel="noreferrer noopener">International Conference in Austria</a>.
At that time, Ivana Magovčević-Liebisch said the two presentations highlight the strong potential of VG-3927. This oral, brain-penetrant TREM2 agonist showed positive results in Phase 1, with good safety, tolerability, and drug activity.
She further explained that VG-3927 could offer a new way to treat Alzheimer&#8217;s disease by targeting more than just amyloid buildup.
Vigil plans to begin Phase 2 trials of VG-3927, the only once-daily oral TREM2 agonist currently in clinical development, later this year.
Vigil&#8217;s monoclonal antibody program, Iluzanebart (VGL101), is excluded from the acquisition by Sanofi. Before the transaction is finalized, the exclusive license agreement with Amgen for VGL101 will be terminated, and the rights to the program will be returned to Amgen, its original licensor.
Price Action: SNY shares were trading lower by 0.36% to $52.71 premarket at last check Thursday, and VIGL shares traded higher by 245.9% at $7.99.
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