La cadena de opciones muestra datos clave de las opciones de acciones de Luminar Technologies a varios precios de ejercicio y fechas de vencimiento. Los operadores utilizan esta información para analizar posibles operaciones y evaluar el sentimiento del mercado para Luminar Technologies..

Luminar Technologies (NASDAQ:LAZR) Bolsa, Cadena de Opciones

Luminar Technologies

Luminar Technologies Inc is an automotive technology company ushering in a new era of vehicle safety and autonomy. It operates its business through the following segments: Autonomy Solutions and Advanced Technologies and Services. The majority of its revenue is generated from the Autonomy Solutions segment, which engages in the design, manufacturing, and sale of LiDAR sensors, catering mainly to the OEMs in the automobile, commercial vehicle, robo-taxi, and adjacent industries. The Advanced Technologies and Services segment provides semiconductors and related components, as well as design, test, and consulting services to the Autonomy Solutions segment and various third-party customers. Geographically, the company derives its key revenue from North America.

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Luminar Technologies Inc

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<figure class="wp-block-image size-full"><img loading="lazy" decoding="async" width="900" height="600" src="https://contributor-assets.benzinga.com/wp-content/uploads/2025/07/16025313/TINCI.jpeg" alt="" class="wp-image-15899" srcset="https://contributor-assets.benzinga.com/wp-content/uploads/2025/07/16025313/TINCI.jpeg 900w,https://contributor-assets.benzinga.com/wp-content/uploads/2025/07/16025313/TINCI-300x200.jpeg 300w,https://contributor-assets.benzinga.com/wp-content/uploads/2025/07/16025313/TINCI-768x512.jpeg 768w" sizes="(max-width: 900px) 100vw, 900px" /></figure>
The lithium battery materials maker aims to use funds from its planned IPO to advance its global expansion, as it grapples with declining profits and weak prices

<h4 class="wp-block-heading">Key Takeaways:</h4>
<ul class="wp-block-list">
<li>Tinci Materials plans to make a Hong Kong IPO, whose proceeds would go to advancing its global expansion strategy </li>
<li>The lithium battery material maker's profit dropped 74.4% last year to 483 million yuan, but showed signs of stabilizing starting in the fourth quarter</li>
</ul>
　
By Lee Shih Ta&nbsp;
Growing global interest in new energy materials is prompting&nbsp;Guangzhou Tinci Materials Technology Co. Ltd.&nbsp;(002709.SZ) to consider trying its hand at global fundraising. The company said it plans to file for a Hong Kong IPO, aiming to see if the market's international investors agree with their Chinese counterparts who have valued its Shenzhen-listed shares at over 35 billion yuan ($4.88 billion). As the listing plan moves forward, all eyes will be watching to see how this lithium-ion battery concept stock fares under scrutiny from the international investors who typically set the tone in Hong Kong.&nbsp;
Tinci says its planned Hong Kong listing aims to further advance its global expansion strategy by building an international capital-raising platform to fund and develop its nascent overseas business, according to a&nbsp;<a href="https://www.szse.cn/disclosure/listed/bulletinDetail/index.html?25226471-b5e0-440d-a528-e1c8d37c92a3=">public filing</a>&nbsp;last week with the Shenzhen Stock Exchange.&nbsp;
Founded in 2000, Tinci started out producing surface-active agents (surfactants), chemical products that reduce the surface tension of a liquid. It moved into the lithium-ion battery electrolyte business in 2011, kicking off a rapid growth phase for the company. Such electrolytes are a key material used to make lithium-ion batteries, whose demand has exploded with the rapid rise of the new energy vehicle (NEV) and energy storage markets.&nbsp;
The company's electrolyte products are widely used in power-generation, storage and 3C digital batteries, with such electrolytes and related raw materials contributing more than 80% of its revenue in 2024. The company accounts for around 13% of the lithium-ion electrolyte market in China, ranking it among the top three players, according to data from Gaogong Lithium Battery and Hua'an Securities.&nbsp;
Tinci supplies its materials to a number of globally renowned battery and auto companies, including domestic giants such as CATL, BYD, Gotion High-tech and EVE Energy, as well as global names like LG New Energy, Samsung SDI, SK On and Tesla. It's also active in the battery supply chains of consumer electronics brands such as Apple, Huawei and Xiaomi, which use lithium-ion batteries in their smartphones and other electronic devices.&nbsp;
<h4 class="wp-block-heading">Tanking gross margin&nbsp;</h4>
While lithium batteries are here to stay, at least for the next decade or two, the industry has become a bloody battlefield lately plagued by price wars and overcapacity. For Tinci, that's translated to tanking profits, even as the company maintains its annual revenue at over 10 billion yuan. Tinci's revenue declined 18.8% year-on-year to 12.52 billion yuan in 2024, as its net profit plunged 74.4% to 483 million yuan, according to its latest annual financial statement.
The company's woes stem from major declines in average prices of its electrolyte products from their earlier highs. Prices of lithium and lithium battery materials plummeted across the board starting in 2023 from record highs, just as demand from the NEV industrial chain started to slow after several years of rapid growth. Compounding the problem was a supply glut that was the result of a major buildup of new manufacturing capacity during the boom.&nbsp;
According to data from IFIND, the price of lithium hexafluorophosphate, a key material in lithium-ion batteries, tumbled from 590,000 yuan per ton to just 70,000 yuan, down more than 90%. That contributed to a drop of more than 60% in the average price of related electrolyte materials. As a result, the unit price for Tinci's electrolyte fell 35% last year, causing its revenue to decline even as it sold 26% more electrolyte material by volume compared with 2023. The falling prices caused the company's gross margin to plunge by 7.8 percentage points to 17.45%, hitting a 19-year low.&nbsp;
Notably, the company's situation seemed to stabilize in the fourth quarter, when its revenue of 3.66 billion yuan was up both quarter-on-quarter and year-on-year. Its net profit for the quarter reached 146 million yuan and its gross margin rebounded to 19.9%, signaling the worst might be in the past. Things continued to improve in the first quarter, with its revenue and profit rising 41.6% and 30.8%, respectively, year-on-year. That could partly explain the rationale for why it's now moving ahead with the Hong Kong IPO plan.
Such a listing would achieve a number of strategic goals. Firstly, it would broaden Tinci's financing channels and offset constraints caused by tight liquidity and volatility in the Shenzhen market. Such a listing could also provide some relief for the company's finances that have come under short-term strain during the downturn.
That said, Tinci still looks like a strong bet over the medium- to long-term, as it continues to hold key technologies and the ability to build out capacity across the globe. Its leadership in the global electrolyte industry also offers international investors a chance to gain exposure to the growth story of China's new energy materials sector.&nbsp;
<h4 class="wp-block-heading">Early global expansion progress</h4>
A Hong Kong listing also offers Tinci a window to attract long-term institutional equity investors and offshore funds, which could help it burnish its global brand image. In a similar move, Tinci has set up a subsidiary in South Korea called Tinci Materials Tech Korea Ltd., and began the construction process for a local electrolyte-production factory to serve Korean clients such as LG New Energy and SK On.&nbsp;
The company is also scouting for sites in Hungary to produce for battery makers serving EV clients in Europe. In addition to factory-building, Tainci is also setting up tech support and sales facilities in countries including Japan, Germany and India to build out its global servicing capabilities. While overseas revenue still accounts for only a limited share of its total, the company hopes to accelerate the international sales contribution as its production lines gradually come online in Asia and Europe.
Despite recent industry woes, Tinci's main electrolyte business still boasts significant advantages in terms of its technological capabilities and a global clientele base. That should position the company for a revival as prices stabilize and demand for next-generation materials continues to grow. Now, the challenge for Tinci will be presenting Hong Kong investors with a positive narrative about prospects for China's new energy materials sector, and its own ability to improve its profitability as the lithium battery sector stabilizes.&nbsp;

IPOs

Opinion

Tinci Materials Plans Hong Kong IPO To Court International Investors

Good Morning Traders! In today&#8217;s Market Clubhouse Morning Memo, we will discuss SPY, QQQ, AAPL, MSFT, NVDA, GOOGL, META, and TSLA.
Our proprietary formula, exclusive to Market Clubhouse, dictates these price levels. This dynamic equation takes into account price, volume, and options flow. These levels are updated every day and shared with all Clubhouse Members, prior to the opening of the market.
We recommend closely monitoring these stocks, and be prepared to leverage potential breakouts or reversals. As always, stay alert and ready to adjust your tactics based on the market&#8217;s pulse to optimize your trading gains. Now, let&#8217;s dive into the stock analysis:
SPDR S&amp;P 500 ETF Trust (SPY)
SPY is presently trading near our important level of 622.00. Bulls are targeting an initial advance to 623.25. If momentum persists above 623.25, we anticipate buyers driving prices toward our next key support at 624.79. Should buyers confidently defend 624.79 throughout regular session trading, look for a continuation upward to 625.65, with our ultimate bullish target for the day sitting at 626.49.
If bulls lose their grip at 622.00, sellers will aim for downside momentum, initially challenging the 620.94 level. Continued bearish pressure will put the 619.65 mark at risk. Breaking this level decisively could see SPY quickly trading down toward the strong support at 617.91. If selling intensifies dramatically, bears might reach our lowest target for the session at 616.36.
Invesco QQQ Trust Series 1 (QQQ)
The QQQ is currently trading near our pivotal level of 555.59. Bulls must firmly establish price action above this mark, subsequently securing 557.52 as reliable intraday support. Persistent bullish sentiment should then encourage further upside momentum, targeting the next resistance at 560.00. If today&#8217;s buying is robust, anticipate a stretch toward 563.38, with our top bullish objective for the QQQ standing at 566.68.
Should QQQ fail to hold 555.59 convincingly during market hours, bears will seize control and push downward aggressively, first testing the 553.84 area. If weakness persists, expect a deeper selloff toward 552.70. Continued bearish dominance could trigger further downside pressure toward the support at 550.98. A breach here opens the door to our lowest bearish target of the day at 549.97.
Apple Inc. (AAPL)
Apple is trading near our crucial price level of 209.27. Bulls should aim to maintain this support, driving the stock upward initially toward 210.58. Sustained buying could elevate Apple to the next upside hurdle at 211.90. If bullish participants decisively dominate today&#8217;s trading, our high-end bullish target of 213.53 becomes attainable.
If buyers fail to defend the critical level at 209.27, bearish sellers will quickly target 208.27 as their first destination. Continuation of selling momentum would bring Apple down to the next support zone at 207.39. A breakdown of that level might induce additional selling toward 206.64, with further weakness potentially reaching our lower bear target at 206.01.
Microsoft Corp. (MSFT)
Microsoft is currently trading near our highlighted level of 504.90. Bulls will first need to secure the area above 504.60, setting the stage for a move upward toward 506.80, which would then act as an intraday support. Holding firmly above 506.80 would position Microsoft for a bullish run toward 508.67, with sustained buyer participation likely pushing prices to our daily bullish target of 511.11.
If 504.90 is not maintained, expect bears to swiftly challenge the 503.73 mark. Breaking below this support will encourage additional downside pressure, targeting 502.18. Should selling intensify, the next bearish objective becomes 500.66, ultimately opening a path toward our lowest bearish target for the session at 499.29.
NVIDIA Corporation (NVDA)
NVIDIA is currently trading around our critical level of 169.92. Bulls must push the price higher initially to reclaim and firmly establish support at 170.96. Continued upward momentum would then open a pathway to the next resistance point at 172.33. Strong buying throughout the day could drive NVIDIA further upward toward 173.67, with our top bullish target today placed at 175.33.
If NVIDIA cannot hold above 169.92, expect bearish sellers to target a move lower initially toward 167.72. A breakdown here with notable selling volume could rapidly take prices down to 166.21. Further weakening could see bears testing 164.90, and continued downside momentum might ultimately push NVIDIA toward our daily bearish objective at 163.91.
Alphabet Inc Class A (GOOGL)
Alphabet is presently trading close to our significant level of 182.68. Bulls will first aim to firmly secure this area as intraday support, targeting a push higher toward resistance at 183.73. Strong bullish activity might then extend this rally to reach today&#8217;s ultimate bullish target of 185.60.
If buyers are unable to protect 182.68, sellers will likely take control and aggressively test support lower at 181.57. If bearish sentiment intensifies, expect the auction to continue downward toward 180.46. Under heavy selling pressure, Alphabet could fall toward our low-end bearish objective of 178.73.
Meta Platforms Inc (META)
Meta is currently trading near our key level of 713.89. Bulls will look to establish firm price strength above 716.60, setting up the opportunity for further advances toward 718.55. Continued bullish conviction should then lift Meta toward the next resistance level at 721.19, with potential for buyers to drive price action toward our bullish target at 723.84.
If Meta fails to maintain support at 713.89, sellers will immediately target a decline to the support level at 709.98. Continued bearish activity would encourage a further drop toward 707.52. Should this area fail to hold, increased selling might accelerate the move down toward our lowest bearish target of the session at 705.52.
Tesla Inc. (TSLA)
Tesla is currently trading around our significant price level of 309.70. Bulls should first target a move upward to 311.98, with continued buying momentum potentially lifting prices to the next resistance at 315.66. If market sentiment is strongly bullish today, Tesla may push higher toward 321.59, with our maximum bullish objective sitting at 323.84.
If the support level at 309.70 is compromised, anticipate sellers moving swiftly to test lower prices around 307.86. Additional bearish pressure would likely bring Tesla down further to 306.02. Failure at this level with intensified selling could prompt further downside to our daily bearish target of 304.63.
Final Word: Today&#8217;s economic calendar starts strong with the June PPI report at 8:30 AM ET, a key measure of wholesale inflation that could significantly affect interest rate expectations and overall market direction if it surprises to the upside or downside. Accompanying this release is the July New York Fed Services Business Activity index, offering early indications of service sector health in a major economic hub. Following at 9:15 AM ET, expect the June Manufacturing Production, Industrial Production, and Capacity Utilization data, which together provide a comprehensive view of industrial output and resource usage, potentially highlighting manufacturing trends amid ongoing supply chain and demand dynamics.&nbsp;
Additionally, several Fed officials are slated to speak: Richmond Fed President Barkin at 8:00 AM ET, Dallas Fed President Hammack at 9:15 AM ET, and Federal Reserve Board Governor Michael Barr at 10:00 AM ET, with their comments likely scrutinized for hints on monetary policy amid recent data.
Given the potential for these high-impact releases and speeches to spark sharp movements, brace for elevated volatility throughout the session, and consider tightening risk controls accordingly. Best of luck with your trades, and approach the day with caution. Stay safe!
For a limited time during our special promotion, you can join RIPS and get a full access pass to Market Clubhouse for 7 full days for just $7. Check it out at <a href="https://marketclubhouse.club/7Days/" title="https://marketclubhouse.club/7Days/">https://marketclubhouse.club/7Days/</a> where you can trade live with him and tap into his wealth of knowledge and experience. You can also catch Rips on his live day trading streams every Monday-Friday at 8 am EST on the Market Clubhouse YouTube channel: <a href="https://www.youtube.com/@MarketClubhouse" title="https://www.youtube.com/@MarketClubhouse">https://www.youtube.com/@MarketClubhouse</a>.

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WIIM

WINT

Windtree shares are trading higher after the company entered a securities purchase agreement to support its BNB crypto treasury strategy.

<ul>
<li>After 12 weeks of treatment, 75% of per-protocol patients receiving 0.05% urcosimod showed greater than 80% reduction in neuropathic corneal pain (NCP), as measured by Visual Analogue Scale (VAS), demonstrating highly effective treatment.</li>
<li>Urcosimod (0.05%) demonstrated a marked reduction in pain scores as early as Week 4, with sustained efficacy maintained throughout the trial.</li>
<li>A statistically significant reduction in mean pain scores was observed from Visit 1 to the end of treatment Visit 4 (p-value = 0.025) in the per-protocol 0.05% urcosimod group, indicating the drug's effectiveness over the study period.</li>
<li>Notably, all these responders entered the study with moderate to severe NCP pain scores despite prior use of maximum medical therapy.</li>
<li>No serious adverse events were reported among the 18 patients throughout the trial.</li>
<li>Following completion of full data analysis, OKYO plans a meeting with FDA to discuss next steps for urcosimod which has already received Fast Track designation for treating NCP.</li>
</ul>
OKYO Pharma Limited (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/OKYO#NASDAQ">OKYO</a>), an ophthalmology-focused bio-pharmaceutical company which is developing urcosimod to treat neuropathic corneal pain (NCP), an ocular condition associated with chronic and often severe nerve-related pain but without an FDA-approved therapy, is pleased to announce positive top-line data from the recently closed 18-patient Phase 2 trial of urcosimod (formerly called OK-101) to treat NCP. OKYO is the first company to conduct a clinical study to treat NCP disease, a major unmet medical need.
This randomized, double-masked, placebo-controlled, Phase 2 Proof-of-Concept trial of urcosimod to treat NCP was conducted at a single trial site at Tufts Medical Center in Boston, MA, with Pedram Hamrah, M.D., a leading expert in NCP, as Principal Investigator.

OKYO

OKYO Pharma Plans To Meet With FDA Following Completion Of Full Data Analysis For Urcosimod, Advancing Fast Track Path For NCP Treatment

Loop Capital analyst Alton Stump maintains Wendy's (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WEN#NASDAQ">WEN</a>) with a Buy and lowers the price target from $21 to $16.

Price Target

Analyst Ratings

Loop Capital Maintains Buy on Wendy's, Lowers Price Target to $16

Piper Sandler analyst John Barnidge maintains Prudential Financial (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PRU#NYSE">PRU</a>) with a Neutral and lowers the price target from $109 to $108.

Piper Sandler Maintains Neutral on Prudential Financial, Lowers Price Target to $108

Morgan Stanley&nbsp;(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MS#NYSE">MS</a>) reported a second-quarter 2025 earnings of $2.13, up from $1.82 a year ago and beating&nbsp;the <a target="_blank" href="https://www.benzinga.com/calendars/earnings" rel="noreferrer noopener">consensus of $2.02</a>. Net earnings increased to $3.54 billion from $3.08 billion.
The U.S. bank&nbsp;<a target="_blank" href="https://www.morganstanley.com/content/dam/msdotcom/en/about-us-ir/shareholder/2q2025.pdf" rel="noreferrer noopener">reported</a> revenue of $16.79 billion, up 12% year over year, beating the&nbsp;consensus of $16.11 billion.
Morgan Stanley's provision for credit losses jumped to $196 million, primarily driven by growth in the corporate loan portfolio and
secured lending facilities, and the impact of a moderately weaker macroeconomic outlook.
Also Read: <a target="_blank" href="https://www.benzinga.com/markets/earnings/25/07/46330576/big-banks-q2-earnings-july-2025" rel="noreferrer noopener">Big Bank Stocks Soared In 2025—But This Earnings Season Could Shake Things Up</a>
The firm's expense efficiency ratio was 71% compared to 72% a year ago.
Morgan Stanley's second-quarter Return on Tangible Common Equity was 18.2%, compared to 17.5% a year ago.
Institutional Securities reported net revenues of $7.6 billion, propelled by
Markets businesses on higher client activity, with notable strength in Equity.
Investment Management results reflect net revenues of $1.6 billion, primarily driven by asset management fees on higher average assets under management (AUM) of $1.71 trillion (up 13%). The quarter included positive long-term net flows of $11 billion.
Wealth management delivered net revenues of $7.76 billion on higher asset management revenues, compared to $6.79 billion a year ago.
The business demonstrated continued strength with net new assets of $59 billion and fee-based asset flows of $43 billion for the quarter.
Equity net revenues increased 23% to $3.72 billion, reflecting increases from a year ago across business lines and regions on higher client activity, with robust results in prime brokerage.
Fixed Income net revenues increased 9% from a year ago to $2.18 billion, primarily driven by higher results in macro products and higher client activity in a more volatile market environment. Lower results in commodities partially offset the increase.
On Wednesday, Chairman and Chief Executive Officer Ted Pick said, "Morgan Stanley delivered another strong quarter. Six sequential quarters of consistent earnings&#8230;reflect higher levels of performance in different market environments. Institutional Securities saw strength and balance across businesses and geographies."
Price Action: MS stock is down 1.38% at $139.64 during the premarket session at the last check Wednesday.
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Photo via Shutterstock

Earnings

Large Cap

Movers

Morgan Stanley's Wealth Management Adds $59 Billion In Net New Assets, AUM Grows To $1.71 Trillion

Piper Sandler analyst Peter Keith maintains Tractor Supply (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSCO#NASDAQ">TSCO</a>) with a Overweight and raises the price target from $60 to $66.

TSCO

Piper Sandler Maintains Overweight on Tractor Supply, Raises Price Target to $66

Windtree Enters $60M Securities Purchase Agreement Led By Build and Build Corp. With Potential For Up To Additional $140M In Gross Proceeds; Proceeds Will Be Primarily Used To Launch BNB Crypto Treasury Strategy

Piper Sandler analyst Nathan Race maintains Nicolet Bankshares (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NIC#NYSE">NIC</a>) with a Neutral and raises the price target from $122.5 to $140.

Piper Sandler Maintains Neutral on Nicolet Bankshares, Raises Price Target to $140

Piper Sandler analyst Stephen Scouten maintains Hancock Whitney (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HWC#NASDAQ">HWC</a>) with a Overweight and raises the price target from $70 to $72.

Piper Sandler Maintains Overweight on Hancock Whitney, Raises Price Target to $72

Alliance Global Partners analyst James Molloy maintains Soligenix (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SNGX#NASDAQ">SNGX</a>) with a Buy and lowers the price target from $10 to $6.

SNGX

Alliance Global Partners Maintains Buy on Soligenix, Lowers Price Target to $6

Barclays analyst Nicholas Campanella maintains Southern (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SO#NYSE">SO</a>) with a Equal-Weight and raises the price target from $90 to $91.

Barclays Maintains Equal-Weight on Southern, Raises Price Target to $91

APED

Trading Halt: Halted at 9:22:59 a.m. ET - Trading Halt: Halt News Pending

<ul>
<li>After 12 weeks of treatment, 75% of per-protocol patients receiving 0.05% urcosimod showed greater than 80% reduction in neuropathic corneal pain (NCP), as measured by Visual Analogue Scale (VAS), demonstrating highly effective treatment.</li>
<li>Urcosimod (0.05%) demonstrated a marked reduction in pain scores as early as Week 4, with sustained efficacy maintained throughout the trial.</li>
<li>A statistically significant reduction in mean pain scores was observed from Visit 1 to the end of treatment Visit 4 (p-value = 0.025) in the per-protocol 0.05% urcosimod group, indicating the drug's effectiveness over the study period.</li>
<li>Notably, all these responders entered the study with moderate to severe NCP pain scores despite prior use of maximum medical therapy.</li>
<li>No serious adverse events were reported among the 18 patients throughout the trial.</li>
<li>Following completion of full data analysis, OKYO plans a meeting with FDA to discuss next steps for urcosimod which has already received Fast Track designation for treating NCP.</li>
</ul>
LONDON and NEW YORK, July 16, 2025 (GLOBE NEWSWIRE) -- OKYO Pharma Limited (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/OKYO#NASDAQ">OKYO</a>), an ophthalmology-focused bio-pharmaceutical company which is developing urcosimod to treat neuropathic corneal pain (NCP), an ocular condition associated with chronic and often severe nerve-related pain but without an FDA-approved therapy, is pleased to announce positive top-line data from the recently closed 18-patient Phase 2 trial of urcosimod (formerly called OK-101) to treat NCP. OKYO is the first company to conduct a clinical study to treat NCP disease, a major unmet medical need.
This randomized, double-masked, placebo-controlled, Phase 2 Proof-of-Concept trial of urcosimod to treat NCP was conducted at a single trial site at Tufts Medical Center in Boston, MA, with Pedram Hamrah, M.D., a leading expert in NCP, as Principal Investigator.
Top Line Data Note: Primary Endpoint of Phase 2 trial was change in mean pain scores from baseline (Visit 1, Day 0) to end of treatment (Visit 4, Day 84), as measured by a VAS scale of 0-10.
For the per-protocol population, change in mean pain score was 5.5 in the 0.05% urcosimod group and 2.75 in the placebo group, reflecting a 2.75 delta difference between drug and placebo following the 12-week treatment period. Notably, 75% of patients treated with 0.05% urcosimod in this group achieved greater than 80% improvement in pain severity based on VAS scores. Urcosimod (0.05%) demonstrated a marked reduction in pain scores as early as Week 4, with a mean change of 5.25 compared to 3.0 in placebo group. Moreover, for the 0.05% urcosimod group a statistically significant reduction in mean pain scores was observed from Visit 1 to the end of treatment Visit 4 (p-value = 0.025). The placebo group also showed a statistically significant improvement from baseline (Visit 1) to the final visit (Visit 4), with a p-value = 0.035. However, mean improvement seen in the placebo group was only half what was seen for the 0.05% urcosimod group (2.75 vs 5.5). Moreover, for the placebo group's reduction from Visit 1 to the end of treatment Visit 4, 75% of those patients had only mild NCP pain scores at baseline. In contrast, all the patients in the 0.05% urcosimod group had moderate to severe NCP pain scores, indicating a more challenging baseline condition.
In the intent-to-treat population, 67% of patients in the 0.05% urcosimod group demonstrated greater than 50% improvement in pain, as measured by VAS scores, compared to 33% in the placebo group. The mean reduction in pain severity from baseline (Visit 1) to end of treatment (Visit 4), measured by VAS, was 4.2 in the 0.05% urcosimod group and 2.5 in the placebo group.
The drug-effect size of 0.05% urcosimod when compared to placebo at week 12, using Cohen-d demonstrated a strong treatment effect (Cohen-d value &gt; 1.2). Cohen-d is a standard statistical measure used to assess and compare the effect size of the trial drug relative to the placebo.
Significant interest in urcosimod has been brought to OKYO's attention by sufferers of NCP during this phase 2 trial, and OKYO will be pushing to accelerate clinical development of urcosimod with further trials in the near future. In addition, several patients from the just completed trial have also requested availability of the drug through FDA's "Expanded Access" program (also referred to as "Compassionate Use") which the Company is planning to arrange, contingent on necessary FDA approvals, for those present patients and future patients who have specifically completed clinical trials on urcosimod.
In line with earlier findings from a previously conducted Phase 2 trial to evaluate urcosimod to treat dry eye disease, results from the 0.1% drug treatment group in this trial also showed less efficacy than the 0.05% drug treatment group. OKYO is continuing to evaluate additional data and plans to present a larger data set from the study after ongoing analyses of the data have been completed.

OKYO Pharma Announces Top-Line Data From Recently Closed 18-Patient Phase 2 Trial Of Urcosimod To Treat NCP

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