| Oct 1, 2026 | Nello Mainolfi | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | — | $57.94 | $3.4M |
| Sep 4, 2026 | Brian Adams | CHIEF LEGAL OFFICER | SELL | 6.371K | $116.83 | $744K |
| Jul 7, 2026 | Nello Mainolfi | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | — | $60.54 | $5.8M |
| Jul 1, 2026 | Noah Goodman | CHIEF BUSINESS OFFICER | SELL | 3.389K | $114.29 | $387K |
| Jul 1, 2026 | Nello Mainolfi | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | — | $58.69 | $9.1M |
| Jun 30, 2026 | Bruce N Jacobs | CHIEF FINANCIAL OFFICER | SELL | 15.731K | $60.15 | $8.5M |
| Jun 29, 2026 | Bruce Booth | — | SELL | 31.283K | $109.48 | $3.4M |
| Jun 26, 2026 | Bruce Booth | — | SELL | 513.245K | $110.01 | $56.5M |
| Jun 26, 2026 | BVF PARTNERS L PIL, BIOTECHNOLOGY VALUE FUND L P, BVF I GP LLC, BIOTECHNOLOGY VALUE FUND II LP, BVF II GP LLC, Biotechnology Value Trading Fund OS LP, BVF Partners OS Ltd, BVF GP HOLDINGS LLC, INCIL BVF, MARK LAMPERT | DIRECTOR | SELL | 1.631M | $106.50 | $173.7M |
| Jun 25, 2026 | Bruce Booth | — | SELL | 285.684K | $121.86 | $34.8M |
| Jun 25, 2026 | Noah Goodman | CHIEF BUSINESS OFFICER | SELL-OPTIONS | — | $67.53 | $465K |
| Jun 23, 2026 | Bruce Booth | — | SELL | 398.765K | $110.31 | $44.0M |
| Jun 22, 2026 | Bruce Booth | — | SELL | 31.798K | $103.75 | $3.3M |
| Jun 22, 2026 | Noah Goodman | CHIEF BUSINESS OFFICER | SELL-OPTIONS | — | $60.02 | $195K |
| Jun 17, 2026 | Bruce Booth | — | SELL | 466.457K | $57.36 | $45.1M |
| May 26, 2026 | Jeremy Chadwick | CHIEF OPERATING OFFICER | SELL | 17.184K | $79.92 | $1.4M |
| May 11, 2026 | Elena Ridloff | — | SELL-OPTIONS | — | $59.10 | $167K |
| Apr 29, 2026 | Nello Mainolfi | CHIEF EXECUTIVE OFFICER | SELL-OPTIONS | — | $41.63 | $2.4M |
