Cardiol Therapeutics Bolsa (NASDAQ: CRDL)

Cardiol Therapeutics (NASDAQ:CRDL) Bolsa

Cardiol Therapeutics

Cardiol Therapeutics Inc is a clinical-stage life sciences company focused on the research and clinical development of anti-inflammatory and anti-fibrotic therapies for the treatment of heart diseases. The company's lead product candidate, CardiolRx, is a pharmaceutically manufactured oral cannabidiol formulation that is being clinically developed for use in heart diseases. Cardiol has received Investigational New Drug Application authorization from the United States Food and Drug Administration to conduct clinical studies to evaluate the efficacy and safety of CardiolRx in two diseases affecting the heart which are a Phase II multi-national trial, the ARCHER trial, in acute myocarditis; and a Phase II multi-center open-label pilot study in recurrent pericarditis.

Cardiol Therapeutics Inc. - Class A Common Shares

Cardiol Therapeutics Inc

JP Morgan analyst Ken Goldman maintains Conagra Brands (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CAG#NYSE">CAG</a>) with a Neutral and lowers the price target from $29 to $26.

News

Price Target

Analyst Ratings

JP Morgan Maintains Neutral on Conagra Brands, Lowers Price Target to $26

Hippo Holdings (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HIPO#NYSE">HIPO</a>) sees FY2025 sales of $420.000 million-$450.000 million vs $450.04 million analyst estimate.

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HIPO

Hippo Holdings Sees FY2025 Sales $420.000M-$450.000M vs $450.04M Est

Contracts

Jacobs Awarded Operational Technology Cybersecurity Contract, Valued At $13.4M, With Hampton Roads Sanitation District

Benchmark analyst Cody Acree reiterates Marvell Tech (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MRVL#NASDAQ">MRVL</a>) with a Buy and maintains $135 price target.

Reiteration

MRVL

Benchmark Reiterates Buy on Marvell Tech, Maintains $135 Price Target

JP Morgan analyst Karen Li upgrades Full Truck Alliance Co (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/YMM#NYSE">YMM</a>) from Neutral to Overweight and raises the price target from $13 to $18.

Upgrades

JP Morgan Upgrades Full Truck Alliance Co to Overweight, Raises Price Target to $18

Needham analyst Mike Cikos maintains MongoDB (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MDB#NASDAQ">MDB</a>) with a Buy and lowers the price target from $415 to $270.

Needham Maintains Buy on MongoDB, Lowers Price Target to $270

Needham analyst Ryan MacDonald reiterates LivePerson (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LPSN#NASDAQ">LPSN</a>) from Hold to Hold.

LPSN

Needham Reiterates Hold on LivePersonto Hold

Needham analyst Ryan MacDonald reiterates Yext (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/YEXT#NYSE">YEXT</a>) with a Buy and maintains $10 price target.

YEXT

Needham Reiterates Buy on Yext, Maintains $10 Price Target

Needham analyst Ryan MacDonald reiterates Veeva Systems (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/VEEV#NYSE">VEEV</a>) with a Buy and maintains $270 price target.

VEEV

Needham Reiterates Buy on Veeva Systems, Maintains $270 Price Target

JP Morgan analyst Brian Essex maintains Zscaler (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ZS#NASDAQ">ZS</a>) with a Overweight and raises the price target from $240 to $250.

JP Morgan Maintains Overweight on Zscaler, Raises Price Target to $250

WIIM

SCNX

Scienture shares are trading higher after the company partnered with Kindeva to launch the 10mg REZENOPY nasal spray for opioid overdose treatment.

Sunrise Realty Trust (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SUNS#NASDAQ">SUNS</a>) reported quarterly earnings of $0.30 per share which missed the analyst consensus estimate of $0.32 by 6.25 percent. The company reported quarterly sales of $3.44 million which missed the analyst consensus estimate of $3.53 million by 2.33 percent.

Earnings

Earnings Misses

SUNS

Sunrise Realty Trust Q4 Adj EPS $0.30 Misses $0.32 Estimate, Sales $3.44M Miss $3.53M Estimate

PSTV

Plus Therapeutics shares are trading higher after the company was granted FDA orphan drug designation for Rhenium Obisbemeda in leptomeningeal metastases in patients with lung cancer.

SCIENTURE HOLDINGS, INC. NASDAQ: SCNX), a holding company for existing and planned pharmaceutical operating companies focused on providing enhanced value to patients, physicians and caregivers through developing, bringing to market, and distributing novel specialty products to satisfy unmet market needs, is pleased to announce that its wholly owned subsidiary, Scienture, LLC ("Scienture"), has entered into a definitive agreement with SUMMIT BIOSCIENCES INC. (a wholly owned subsidiary of Kindeva Drug Delivery L.P. ("Kindeva")), for the exclusive U.S. rights to commercially launch REZENOPY&#xAE; (naloxone HCl) Nasal Spray 10mg, an opioid antagonist that was approved by the FDA on April 19, 2024.
Under the terms of the collaboration, Kindeva will manufacture and commercially supply REZENOPY&#xAE; (naloxone HCl) Nasal Spray 10mg. Scienture will own the new drug application (NDA) for REZENOPY&#xAE; in its name and be responsible for the sales, marketing and distribution of the product in the U.S. through Scienture's commercial operations infrastructure.
REZENOPY&#xAE; is the most potent (highest strength) version of naloxone HCl available in the market. The product leverages the proven use of the active ingredient and form factor, with increased effectiveness against potent opioids.
The addition of REZENOPY&#xAE; to Scienture's product portfolio aligns with Scienture's mission to provide innovative treatment solutions across therapeutic areas and expand access to patients. This product collaboration represents a strategic step in advancing public health initiatives and ensuring that life-saving interventions are readily available to those at risk of opioid overdose. As opioid-related fatalities continue to rise, Scienture is dedicated to collaborating with healthcare professionals, policymakers, and advocacy groups to enhance awareness, education, and distribution efforts.
Nasal delivery of Naloxone HCl has been widely recognized for its efficacy, ease of use, and accessibility, making it an essential tool for first responders, healthcare providers, and community programs. IQVIA data (MAT December 2024) indicates a total annual sales of $189 million, unit volume of $10.0 million (eaches) for Naloxone in the US market.

Government

Regulations

Scienture Partners with Kindeva to Launch 10mg REZENOPY Nasal Spray for Opioid Overdose Treatment, Secures Exclusive US Rights to FDA-Approved Spray

GBTG

Amex GBT Receives Approval From UK Competition And Markets Authority To Complete Its Acquisition Of CWT

HC Wainwright &amp; Co. analyst Raghuram Selvaraju reiterates Axsome Therapeutics (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AXSM#NASDAQ">AXSM</a>) with a Buy and maintains $200 price target.

AXSM

HC Wainwright & Co. Reiterates Buy on Axsome Therapeutics, Maintains $200 Price Target

Medicus Pharma Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MDCX#NASDAQ">MDCX</a>) ("Medicus" or the "Company") is pleased to announce a positively trending interim analysis for SKNJCT-003 Phase 2 clinical study to non-invasively treat basal cell carcinoma of the skin (BCC).
The SKNJCT-003 clinical study is currently underway in nine (9) clinical sites in United States and is expected to randomize 60 patients. The interim analysis was conducted after more than 50% of the targeted 60 patients in the study were randomized.
The interim analysis shows the clinical study SKNJCT-003 is trending positively with a proportion of subjects with complete clinical clearance of more than 60%. The analysis also shows the investigational product, D-MNA was well tolerated for both dose levels, a low-dose group receiving 100ug of D-MNA and a high-dose group receiving 200ug of D-MNA in all participants so far enrolled in the study, with no dose limiting toxicities (DLTs), or serious adverse events (SAEs). In addition, there were no systemic effects or clinically significant abnormal findings in laboratory parameters, vital signs, ECGs, and physical examination. The findings of the interim analysis are preliminary and may or may not correlate with the findings of the study once completed.
The Company plans to submit the interim analysis to the United States Food and Drug Administration (FDA) as part of a package seeking a Type C meeting with the FDA in Q2 2025. The purpose of the Type C meeting is to formally discuss the product development and gain further alignment on the clinical pathway. The Company's aim is to gain FDA's consent to fast-track the clinical development program.
"We are immensely encouraged by the positively trending interim analysis", stated Dr. Raza Bokhari, Executive Chairman &amp; CEO. "The interim analysis brings us one step closer to delivering a novel, non-invasive treatment for BCC".
Clinical Trial Design&nbsp;
The clinical study is designed to be a randomized, double-blind, placebo-controlled (P-MNA), multi-center study enrolling up to 60 subjects presenting with BCC of the skin. The study will evaluate the efficacy of two dose levels of D-MNA compared to a placebo control. The participants will be randomized 1:1:1 to one of three groups: a placebo-controlled group receiving P-MNA, a low-dose group receiving 100μg of D-MNA, and a high-dose group receiving 200μg of D-MNA.
The high-dose, 200μg D-MNA, proposed in the study is the maximum dose that was used in the Company's Phase 1 safety and tolerability study (SKNJCT-001) completed in March 2021. SKNJCT-001 met its primary objective of safety and tolerability. The investigational product, D-MNA, was well tolerated across all dose levels in all 13 participants enrolled in the study, with no dose-limiting toxicities (DLTs), or serious adverse events (SAEs). Furthermore, there were no systemic effects or clinically significant abnormal findings in laboratory parameters, vital signs, ECGs, and physical examinations. The study also describes the efficacy of the investigational product, D-MNA, with 6 participants experiencing complete responses. The complete response is defined as the disappearance of BCC histologically in the final excision at the end of study visit. The participants profile demonstrating complete responses was diverse, and all participants (6/6) had nodular subtype of BCC.
The Company also has submitted a clinical design (SKNJCT-004) to United Arab Emirates (UAE) Department of Health (DOH). The study is expected to randomize 36 patients in four sites in UAE, which are Cleveland Clinic Abu Dhabi&nbsp;(CCAD), Sheikh Shakbout Medical City (SSMC), Burjeel Medical City (BMC), and American Hospital of Dubai (AHD).

MDCX

Medicus Pharma Reports Interim Results in Phase 2 Trial for Non-Invasive Skin Cancer Treatment,  Seeks FDA Meeting After Promising 60% Clearance Rate in Basal Cell Carcinoma Study

Smart Share Global Q3 Revenues $69.9M, Down 20% YoY

While the short interest on the outstanding shares of Michael Saylor&#8216;s Strategy Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MSTR#NASDAQ">MSTR</a>) fell during its latest reporting period, implying a positive investor confidence, a mixed set of technical indicators highlighted the stock&#8217;s vulnerable position.
<h3 class="wp-block-heading">MSTR Short Interest Falls</h3>
The short interest on Strategy&#8217;s <a href="https://www.benzinga.com/25/03/44087250/strategys-saylor-calls-crypto-reserve-bullish-for-bitcoin-predicts-100-trillion-opportunity">stock</a> (formerly MicroStrategy) decreased during the last reporting period, falling from 24.01 million to 22.92 million shares. About 9.54% of the company&#8217;s publicly available shares were shorted as of the settlement date on Feb. 14, having an effective date of Feb. 26. 
According to Nasdaq <a href="https://www.nasdaq.com/market-activity/stocks/mstr/short-interest">data</a>, the short interest decreased by 4.53% from the previous settlement date of Jan. 31.
The average daily trading volume during the latest period increased from 18.10 million to 12.45 million shares. The volume indicated that it would require approximately 1.84 days for the short sellers to cover their positions without significantly impacting the stock price.
While high short interest signals bearishness; a decline indicates rising confidence. Hence, the 4.53% decline was a positive indicator.
<h3 class="wp-block-heading">Technical Analysis</h3>
Despite a reduction in the number of shorts, the technical indicators painted a mixed picture for the stock. As the stock closed at $308.55 apiece on Wednesday, it was clearly in a long-term uptrend, as it&#8217;s above its 200-day moving average of $234.93. Additionally, the stock showed short term bullishness by being above its eight- and 20-day moving averages.
However, it was below its 50-day moving average of $327.32 which indicated a potential intermediate-term weakness, according to <a href="https://pro.benzinga.com/dashboard">Benzinga Pro</a>.
The relative strength index of 50.95 was in the neutral zone. But a negative MACD of -15.84 suggested a bearish momentum.
Thus, while long term trends are positive, recent momentum is negative.
<figure class="wp-block-image size-large"><a href="https://pro.benzinga.com/dashboard"><img loading="lazy" decoding="async" width="1024" height="576" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06072101/MSTR-Technical-chart-1024x576.png" alt="" class="wp-image-812018" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06072101/MSTR-Technical-chart-1024x576.png 1024w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06072101/MSTR-Technical-chart-300x169.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06072101/MSTR-Technical-chart-768x432.png 768w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06072101/MSTR-Technical-chart-1536x864.png 1536w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06072101/MSTR-Technical-chart.png 1920w" sizes="(max-width: 1024px) 100vw, 1024px" /></a></figure>
See Also: <a href="https://www.benzinga.com/general/market-summary/25/03/44160509/starlinks-european-rival-up-over-600-since-trump-halted-ukraine-aid-now-plans-to-replace-elon-musks-satellite-internet-service-in-war-torn-nation">Starlink&#8217;s European Rival, Up Over 600% Since Trump Halted Ukraine Aid, Now Plans To Replace Elon Musk&#8217;s Satellite Internet Service In War-Torn Nation</a>
Price Action: On Wednesday, Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) treasury company, MSTR rose 12.14% outpacing the gains in the exchange-traded fund tracking the Nasdaq 100 index, Invesco QQQ Trust, Series 1 (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QQQ#NASDAQ">QQQ</a>), which rose 1.30%. In premarket on Thursday, MSTR was down 1.22%, whereas QQQ declined 1.25%.
The stock remains 2.85% higher on a year-to-date basis, however, it&#8217;s up 147.59% over a year.
<a href="https://www.benzinga.com/quote/MSTR/analyst-ratings">Benzinga tracks 14 analysts</a> with an average price target of $494.93 for the stock, reflecting a &#8220;buy&#8221; rating. Estimates range widely from $140 to $690. Recent ratings from Barclays, Keefe, Bruyette &amp; Woods, and Maxim Group average at $493.67, suggesting a potential 61.290% upside.
<figure class="wp-block-image size-large"><a href="https://www.benzinga.com/quote/MSTR/analyst-ratings"><img loading="lazy" decoding="async" width="1024" height="388" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06071721/Strategy-ANR-1024x388.png" alt="" class="wp-image-812016" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06071721/Strategy-ANR-1024x388.png 1024w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06071721/Strategy-ANR-300x114.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06071721/Strategy-ANR-768x291.png 768w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/03/06071721/Strategy-ANR.png 1062w" sizes="(max-width: 1024px) 100vw, 1024px" /></a></figure>
Read Next:
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<li><a href="https://www.benzinga.com/25/03/44070799/mark-cuban-supports-trumps-new-gold-card-scheme-if-sold-to-corporations-for-employee-citizenship-have-a-look-at-the-listed-companies-with-most-number-of-immigrants">Mark Cuban Supports Trump&#8217;s New &#8216;Gold Card&#8217; Scheme If Sold To Corporations For Employee Citizenship: Here&#8217;re The Listed-Companies With Most Number Of Immigrants</a></li>
</ul>
Photo courtesy: Shutterstock

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MSTR Short Interest Falls 4.53% But Technical Analysis Reveals Mixed Signals: Is Michael Saylor's Strategy Poised For A Bounce Back?

<a target="_blank" href="https://www.benzinga.com/topic/openai" rel="noreferrer noopener">ChatGPT parent</a> OpenAI could charge up to $20,000 monthly for specialized AI &#8220;agents,&#8221;&nbsp;the Information <a target="_blank" href="https://www.theinformation.com/articles/openai-plots-charging-20-000-a-month-for-phd-level-agents" rel="noreferrer noopener">reports</a>.
The Microsoft Corp (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MSFT#NASDAQ">MSFT</a>) backed AI startup plans to launch several &#8220;agent&#8221; products tailored for different applications, including sorting and ranking sales leads and software engineering.
OpenAI plans to charge $2,000 monthly for a &#8220;high-income knowledge worker&#8221; agent and $10,000 monthly for a software developer agent.
Also Read: <a target="_blank" href="https://www.benzinga.com/media/25/03/44140452/gm-stellantis-supplier-samsung-sdi-weighs-new-us-battery-plant-amid-trumps-ev-policy-shift" rel="noreferrer noopener">GM, Stellantis Supplier Samsung SDI Weighs New US Battery Plant Amid Trump&#8217;s EV Policy Shift</a>
OpenAI&#8217;s $20,000-per-month AI agent will likely support &#8220;PhD-level research.&#8221; Reportedly, OpenAI investor SoftBank (OTC:<a class="ticker" href="https://www.benzinga.com/stock/SFTBF#OTC">SFTBF</a>) (OTC:<a class="ticker" href="https://www.benzinga.com/stock/SFTBY#OTC">SFTBY</a>) committed to spending $3 billion on OpenAI&#8217;s agent products in 2025.
OpenAI and Microsoft <a target="_blank" href="https://www.benzinga.com/news/24/10/41407196/openais-for-profit-structure-adds-valuation-complexity-to-microsoft-and-other-equity-investors-repor" rel="noreferrer noopener">reportedly negotiated how</a> to convert Microsoft&#8217;s $14 billion investment into equity amid OpenAI&#8217;s $157 billion valuation.
Both companies enlisted financial advisors to navigate the high-stakes discussions as OpenAI transitions to a for-profit model.
OpenAI&#8217;s projected computing expenses could reach $37.5 billion annually by 2029. OpenAI, whose&nbsp;monthly revenue hit&nbsp;$300 million in August, proposed increasing the chatbot&#8217;s price by 10% in 2024 and doubling it to $44 over the next five years.
Meanwhile, in China, Alibaba Group Holding (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BABA#NYSE">BABA</a>) recently <a target="_blank" href="https://www.benzinga.com/25/02/44040003/alibaba-expands-ai-workforce-while-deepseek-slashes-model-prices-in-market-battle" rel="noreferrer noopener">introduced 3,000 internships</a>, half of which are in AI. It committed $52.2 billion in AI and cloud investment.
Alibaba&#8217;s move coincided with Chinese AI startup&nbsp;DeepSeek&#8217;s AI model price war, offering discounted off-peak pricing for developers. Chinese tech companies like&nbsp;Alibaba and its rivals were already&nbsp;engaged in a price war&nbsp;to win market share.&nbsp;
Price Action: MSFT stock is down 1.26% at $395.97 premarket at the last check on Thursday.
Also Read:
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<li><a href="https://www.benzinga.com/25/03/44136859/asml-faces-uncertainty-as-us-sanctions-on-china-cut-demand-stock-down-24-in-12-months" target="_blank" rel="noreferrer noopener">Chip Equipment Maker ASML Faces Uncertainty As US Sanctions On China Impact Demand</a></li>
</ul>
Image via Shutterstock

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ChatGPT Parent OpenAI's Specialized AI Agents Could Cost Up To $20 Thousand Per Month: report

Press Releases

Spotlight on Undervalued Nasdaq Stocks: HCWB, CRDL, NIVF, SINT, APLM – A Must-Watch This Week!

Cardiol Therapeutics (Nasdaq: CRDL) Advances Orphan Drug Designation for CardiolRx™ at the American Heart Association…more stocks inside…

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Thanksgiving Week Oversold Stocks to Watch: CRDL, QBTS, PRSO, RGTI & More!

"Market Movers: CTOR, CTNT, PNPN.V, KITT, SHIM – More Stocks Inside to Watch"

"Cardiol Therapeutics (NASDAQ: CRDL) Heart Health Innovation – AVCO, GXAI, UPC, and More Stocks Driving Groundbreaking Advances"

PRISM MarketView Features Q&A with President and CEO David Elsley: Cardiol Therapeutics Enters Phase 3 Clinical Trial for CardiolRx™ Addressing Patients with Recurrent Pericarditis

Cardiol Therapeutics to Present at Oppenheimer 35th Annual Healthcare Life Sciences Conference

Cardiol Therapeutics Announces Publication of Research in the Journal of the American College of Cardiology: Basic to Translational Science That Supports Development of Its Proprietary Subcutaneous Drug Candidate, CRD-38, for the Treatment of Heart Failure

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