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BICARA THERAPEUTICS INC

Bicara Therapeutics

Bicara Therapeutics Inc is a clinical-stage biopharmaceutical company bringing transformative bifunctional therapies to patients with solid tumors. Its program ficerafusp alfa is a bifunctional antibody that combines two clinically validated targets, an epidermal growth factor receptor, or EGFR, directed monoclonal antibody with a domain that binds to human transforming growth factor beta, or TGF-b.

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Explora los mayores ganadores y perdedores en las operaciones previas al mercado. Descubre qué impulsó estos movimientos destacados.

Las acciones de Versus Systems (VS) aumentan un 71%; 20 acciones que se mueven en el premercado de EE.UU.

Bicara Therapeutics Inc

<a href="https://www.marijuanamoment.net/exploring-psychedelic-medicine-is-a-top-priority-for-trump-administration-fda-commissioner-says/" title="https://www.marijuanamoment.net/exploring-psychedelic-medicine-is-a-top-priority-for-trump-administration-fda-commissioner-says/">https://www.marijuanamoment.net/exploring-psychedelic-medicine-is-a-top-priority-for-trump-administration-fda-commissioner-says/</a>

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"PoliticsExploring Psychedelic Medicine Is A 'Top Priority' For Trump Administration, FDA Commissioner Says" - Marijuana Moment

DA Davidson analyst Alex Platt maintains Nebius Group (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIS#NASDAQ">NBIS</a>) with a Buy and raises the price target from $35 to $45.

Price Target

Analyst Ratings

NBIS

DA Davidson Maintains Buy on Nebius Group, Raises Price Target to $45

Thumzup Media (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TZUP#NASDAQ">TZUP</a>) reported quarterly losses of $(0.22) per share. This is a 450 percent decrease over losses of $(0.04) per share from the same period last year. The company reported $151.00 in sales this quarter. This is a 62.72 percent decrease over sales of $405.00 the same period last year.

Earnings

TZUP

Reported May 15, 2025: Thumzup Media Q1 EPS $(0.22) Down From $(0.04) YoY, Sales $151.00 Down From $405.00 YoY

Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) currently stands at $103,015.71, and has fallen 0.41% in a day and 0.79% over the week, but <a href="https://www.benzinga.com/money/how-to-buy-bitcoin-btc-best-bonuses-august-2024">still had a 21.02% growth in the month</a>. The price makes Bitcoin a resource for El Salvador, whose profit on BTC holdings has crossed over $300 million.
The government&#8217;s BTC now sits on a staggering $357 million unrealized profit, by far the largest margin since the country started investing in Bitcoin. When prices of Bitcoin recently came close to their all-time high, President Nayib Bukele reaffirmed to buy and hold Bitcoin, even amid ongoing criticism and conditions attached to the International Monetary Fund's (IMF) funding deal for the nation.
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Bukele revealed that the Bitcoin reserve of El Salvador is currently valued at approximately $644.4 million, compared to a total acquisition cost of $287.1 million. The holdings amount to approximately 6,181 BTC, and the majority of the profits, $69.8 million, were gained this year.
Although they had a deal with the IMF to cut down on some of the Bitcoin initiatives, Bukele has decided to go against the agency. He publicly vowed not to undo the country&#8217;s BTC activities, stating that they will keep supporting Bitcoin regardless of foreign pressure.
The Bitcoin network is experiencing increased activity, with its average transaction fee reaching a 2025 high. The fee has increased to $2.40, a steady increase since the start of May. An increase in trading volume has created more demand for Bitcoin&#8217;s limited blockspace. The daily transaction volume dropped 35% from its April 22 peak. This divergence is proof of more high-value transactions and increased congestion.
Bitcoin&#8217;s illiquid supply, comprising wallets with zero or little history of spending, has hit record highs As increasingly more BTC is put into long-term storage, the amount of available supply on exchanges is declining, which may lead to a supply squeeze if demand keeps rising.
Despite its recent fall from $107,068, Bitcoin&#8217;s price is not too far from its all-time high. A new high is possible, especially if macroeconomic tailwinds such as easing trade tensions and central bank policy hints continue to favor crypto markets.
As institutional support remains and long-term investors lock more BTC away, the market is waiting for the next big price action. While there's great optimism, we still need to wait to see whether Bitcoin will break through resistance and set new record highs.
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Coverage of Bitcoin, Etherum, Ripple and all the latest digital currencies.

Cryptocurrency

$BTC

Bitcoin Back To $103k As El Salvador Shuns IMF Deal, Australia Forfeits BTC Proceeds

Thumzup Recently Added Stripe's New Crypto Payment Option for Advertisers
Company's Utilization of Bitcoin and Crypto Aligns with White House Plans to Make the USA the Crypto Capital of the World
LOS ANGELES, May 19, 2025 /PRNewswire/ -- <a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4430769-1&amp;h=3351642801&amp;u=https%3A%2F%2Fwww.thumzupmedia.com%2F&amp;a=Thumzup">Thumzup</a><a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4430769-1&amp;h=3320532072&amp;u=https%3A%2F%2Fwww.thumzupmedia.com%2F&amp;a=Media+Corporation">Media Corporation</a> ("Thumzup" or the "Company") (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TZUP#NASDAQ">TZUP</a>) today announced it has expanded its cryptocurrency capabilities by enabling Stripe's "Pay with Crypto" to accept stablecoins like USDC as payments for Thumzup advertising campaigns.
This important development comes as Thumzup is moving to accelerate its Bitcoin acquisition strategy, which, as previously disclosed, permits the Company to hold up to 90% of its liquid assets in BTC. As of May 19, 2025, Thumzup currently holds 19.106 BTC, with a market value of approximately $2.0 million. Thumzup currently utilizes Coinbase Prime as its custodian and prime broker.

Thumzup Announces It Recently Added Stripe's New Crypto Payment Option For Advertisers; As of May 19, 2025, Thumzup Currently Holds 19.106 BTC, With A Market Value Of ~$2M

D. Boral Capital analyst Jason Kolbert downgrades Imunon (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IMNN#NASDAQ">IMNN</a>) from Buy to Hold.

Downgrades

IMNN

D. Boral Capital Downgrades Imunon to Hold

<ul class="wp-block-list">
<li>American consumer debt hit $18.2 trillion in the Q1 2025, according to the Federal Reserve Bank of New York</li>
<li>While credit card and auto loan balances are both declining, student loan debt and mortgage balances have increased</li>
<li>Student loan debt was also identified as the primary driver behind delinquent debt, which increased 4.3% over the last quarter</li>
</ul>
Americans' consumer debt hit an all-time high in the Q1 2025, according to the Federal Reserve Bank of New York's "Quarterly Report on Household Debt and Credit." The <a href="https://www.newyorkfed.org/microeconomics/hhdc">report</a>, which was released Tuesday, says that household debt is at $18.2 trillion, up $167 billion since Q4 2024.
In two categories, credit card balances and auto loan balances, Americans are actually lowering their debt loads. According to the report, credit card balances fell by $29 billion and auto loan balances decreased by $13 billion.&nbsp;
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However, Ted Rossman, a senior industry analyst at Bankrate, told <a href="https://www.cnn.com/2025/05/13/business/household-debt-report-credit-cards-student-loans">CNN</a>, "Don't be fooled by the modest decrease[s]. Credit card balanc﻿es and interest rates remain near record highs." According to Rossman, credit card balances are 54% higher than they were four years ago, and auto loan balances have gone up by 19% over the same period.&nbsp;
The long-term upward trend of credit balances is unsurprising. The NY Fed's data does not account for inflation, or factor in things like population growth, the rise of e-commerce, or the strength of consumer spending.
What is surprising to analysts and experts, however, is the drop in auto loan balances. These fell for the first time since 2011, according to CNN.
Matt Schultz, chief consumer finance analyst at LendingTree, explained the phenomenon to CNN. "I think it's a combination of people not buying [cars] because of high interest rates and high prices and also just the amount of uncertainty that we have had in the economy the last few months," he said. "That may have spurred people to hunker down a little bit."
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Two other categories of consumer debt, student loan balances and mortgage balances, saw an increase in debt loads. Student loan balances grew by $16 billion to $1.63 trillion, and mortgage balances went up by $199 billion to $12.8 trillion. Aggregate delinquency rates also rose this quarter, with 4.3% of debt now in some stage of delinquency.&nbsp;
Student loans are one of the chief drivers of delinquent debt. After a 3.5 year pause on payments and the end of President Joe Biden's one-year "on-ramp" extension, student loans payments have resumed in full as of Sept. 30, and missed payments now affect credit reports.&nbsp;
According to the NY Fed's new report, student loan delinquencies have jumped from 1% to 7.74% in the Q1. While half of the newly delinquent borrowers already had subprime credit scores, 2.4 million others had scores of above 620 and saw them drop more than 140 points.&nbsp;
Charlie Wise, head of global research and consulting at TransUnion, told CNN this could have severe impacts on the average borrower. "Consumers who previously would have had very good access to most credit products, including mortgages, now will have a much more difficult time getting credit — if at all," he said.
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Personal Finance

Americans' Consumer Debt Hits All-Time High of $18.2 Trillion, Experts Say Some Borrowers 'Will Have A Much More Difficult Time Getting Credit' Going Forward

Johnson Controls Intl (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/JCI#NYSE">JCI</a>) has outperformed the market over the past 5 years by 12.16% on an annualized basis producing an average annual return of 27.07%. Currently, Johnson Controls Intl has a market capitalization of $63.64 billion. 
Buying $1000 In JCI: If an investor had bought $1000 of JCI stock 5 years ago, it would be worth $3,327.10 today based on a price of $96.41 for JCI at the time of writing.
<h3>Johnson Controls Intl's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1747667712_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

$1000 Invested In Johnson Controls Intl 5 Years Ago Would Be Worth This Much Today

PARA

Reuters Reports Wendy McMahon To Step Down As President And CEO Of CBS News And Stations And CBS Media Ventures

Canaccord Genuity analyst Kyle Mikson maintains Akoya Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AKYA#NASDAQ">AKYA</a>) with a Hold and lowers the price target from $1.8 to $1.08.

AKYA

Canaccord Genuity Maintains Hold on Akoya Biosciences, Lowers Price Target to $1.08

As Moody's strips the U.S. of its last AAA credit rating, financial markets and currency analysts are weighing whether the dollar's role as the world's primary reserve <a href="https://www.benzinga.com/25/05/45492889/americas-credit-strength-just-got-cut-again-should-you-panic">currency could slowly erode. </a>
Analysts across major institutions agree that Treasuries remain indispensable in global finance, and no mechanical turmoil is expected in the near term.
Yet, the downgrade's timing and symbolism—arriving amid growing fiscal deficits, political uncertainty and weakening sentiment—have amplified calls for greater diversification from dollar-denominated investments for foreign investors.
<h3 class="wp-block-heading">Dollar&#8217;s Dominance Isn't Over, But It's Under Pressure</h3>
"The link between U.S. sovereign risk, Treasuries, and the dollar is one of capital flight," said Chris Turner, analyst at ING Group. 
"Are global investors shifting their portfolios away from the U.S.?" 
He highlighted that March data from the U.S. Treasury's International Capital report showed foreign buyers added $26 billion in Treasuries, though China trimmed its holdings by $19 billion. 
Turner said upcoming TIC data for April, due mid-June, will be key to determining any real trend.
<h3 class="wp-block-heading">Downgrade Could Spark Market Volatility</h3>
According to Alejandro Cuadrado, forex strategist at BBVA, Moody's downgrade—though symbolic—arrives at a vulnerable time.
"It may act as a psychological catalyst," he said. Unlike S&amp;P's 2011 or Fitch's 2023 downgrades, this one coincides with bearish sentiment in Treasuries and rising global fiscal concern.
Cuadrado said the structural use of Treasuries in collateral systems, reserve portfolios and liquidity management remains unchanged. 
Still, "in this macro environment, the downgrade could amplify market jitters and FX volatility," he said, potentially weakening the dollar's ability to rebound after a three-month slide.
"The downgrade highlights long-term risks, including debt sustainability, which could further erode the dollar's haven appeal," George Vessey, lead macro strategist at Convera, said.
<h3 class="wp-block-heading">Time to Start Reducing Dollar Exposure?</h3>
According to UBS, the recent consolidation in the dollar following earlier weakness offers a strategic moment for reallocation.
"We believe that this provides an opportunity for investors with excess USD cash, or international investors with unhedged exposure to U.S. assets, to reduce their exposure to the U.S. dollar."
Over the long term, UBS sees further structural risks. "The trend of international diversification could lead to further dollar weakness, particularly if the Federal Reserve begins to play a more active role intervening in bond markets amid high fiscal deficits."
<h3 class="wp-block-heading">Not A Collapse For Now, Yet Caution Is Warranted</h3>
The Dollar Index (DXY) – which is tracked by the Invesco DB USD Index Bullish Fund ETF (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UUP#NYSE">UUP</a>) – fell 0.8% on Monday, erasing gains from last week on the back of a U.S.-China trade truce.
Capital flight hasn't hit the data yet, but concerns about U.S. debt and policy are starting to grow worldwide.
For the time being, the dollar remains the anchor of global trade and finance—but the psychological buffer it once enjoyed is showing cracks, and that shift may matter more than a credit downgrade.
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</ul>
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ETFs

PowerShares DB US Dollar Index Bullish Fund

Is The Dollar's Global Reserve Role At Risk After Moody's Downgrade?

Snowflake Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SNOW#NYSE">SNOW</a>), a cloud-based data storage provider, will report its first-quarter results <a href="https://www.benzinga.com/topic/cloud">on Wednesday, May 21</a>.
According to Goldman Sachs, Snowflake's fundamentals are strengthening, and the company is likely to report strong quarterly results and guidance.
The Snowflake Analyst: <a href="https://www.benzinga.com/analyst-stock-ratings/analyst/58c6ab8db85e9300015f1ae0/kash-rangan">Analyst Kash Rangan</a> maintained a Buy rating and price target of $205.
The Snowflake Thesis: The Bozeman, Montana-based company is likely to report Product Revenue growth of 21% and non-GAAP operating margins of 5%, in-line with consensus estimates, Rangan said in the note.
Check out <a href="https://www.benzinga.com/analyst-stock-ratings">other analyst stock ratings</a>.
There is potential for "beat and flow-through, supported by Datadog and Hyperscalers seeing stable consumption trends in April," he added.
Core Data Engineering is scaling quickly, driven by Snowpark and Dynamic Tables, while Cortex could benefit from AI momentum into the back half of the year, the analyst stated. Recent partnerships with Microsoft/OpenAI and Anthropic help Snowflake increase credibility and reach, he further stated.
"We believe Snowflake's strengthening fundamentals, new product velocity under CEO Ramaswamy's strategic leadership, a more efficient GTM motion, and recent tariff relief serve as net-positives for underwriting 2H growth acceleration," Rangan wrote.
Price Action: Shares of Snowflake had declined by 0.45% to $182.34 at the time of publication on Monday.
Read More: 
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/analyst-ratings/price-target/25/05/45262278/under-armour-faces-tough-road-ahead-says-analyst">Snowflake (SNOW) Stock Gains Amid Tech Rally, CPI Miss: What&#8217;s Going On?</a></li>
</ul>
Image: Shutterstock

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Reiteration

Tech

SNOW

Snowflake Eyes Q1 Momentum As AI Partnerships Stack Up: Goldman Sachs

LHSW

Lianhe Sowell International Shares Resume Trade

Solana (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/sol/usd">SOL</a>) <a href="https://www.benzinga.com/money/how-to-buy-solana#:~:text=Make%20Your%20Purchase&amp;text=To%20complete%20the%20transaction%2C%20head,you%20would%20like%20to%20purchase.">dropped 5% to $161.85 on May 19</a> after a three-day rally to $171.72, as profit-taking followed a burst of meme-coin activity and infrastructure news. While the pullback pressured price near key technical levels, underlying signals point to sustained ecosystem growth, developer momentum, and institutional engagement.
Solana&#8217;s first quarter app revenue surged 20% quarter-over-quarter to $1.2 billion, according to The Crypto Times. Pump.fun led with $257 million in revenue, highlighting Solana&#8217;s position as the hub for fast-moving meme coin launches. The stablecoin market cap on the chain soared 145% QoQ to $12.5 billion, even as DeFi TVL declined roughly 64%.
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DEX volumes jumped over 40% to $4.6 billion, and meme tokens like TrumpCoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/">TRUMP</a>) and MelaniaCoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/">MELANIA</a>) posted multi-day gains of 2x or more. On May 19, a whale wallet spent nearly $5.9 million on Solana meme coins, including WIF, Fartcoin, and BONK, per CryptoTimes.
Separately, DeFi Development Corp. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DFDV#NASDAQ">DFDV</a>) formed a validator partnership with BONK, co-running a node that bridges public markets with crypto-native assets.
Derivatives markets show positioning into strength. Open interest in SOL futures climbed 9% to $2.1 billion on Binance (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/bnb/usd">BNB</a>), with a broader total of ~$5.55 billion across exchanges. Funding rates remain neutral to slightly negative, suggesting cautious bullishness without frothy leverage.
Daily active addresses rose 18% week-over-week to 1.2 million, and large wallet holders with 10,000+ SOL have increased by 1.5%, signaling accumulation rather than exit.
SOL is hovering around its 200-day moving average at $162. A confirmed break below $160 could open a path to the $145–$150 range, according to CoinGlass. Resistance sits near $180.45, with a potential upside target of $190 if sentiment rebounds.
Bitcoin&#8217;s (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) tight consolidation around $103,000 has redirected trader focus to higher-beta assets like SOL. This inter-asset flow continues to amplify price volatility across Solana-linked tokens.
Forward-looking catalysts include U.S. regulatory updates, staking reward changes, and broader institutional integrations. CoinCodex notes that a break above $190 could set up a retest of the $200 level last reached in Q1.
Despite the short-term pullback, Solana&#8217;s core metrics—rising app revenue, surging stablecoin use, dev growth, and enterprise adoption—suggest the dip is more consolidation than reversal. The fundamentals remain intact, and the bid from whales, builders, and institutions appears to be holding.
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</ul>
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$BNB

$MELANIA

$SOL

$TRUMP

DFDV

Solana Slides As Meme-Coin Rally Cools, Enterprise Engagement And Open Interest Stay Hot

Macquarie analyst Tim Nollen maintains Trade Desk (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TTD#NASDAQ">TTD</a>) with a Outperform and raises the price target from $90 to $92.

Macquarie Maintains Outperform on Trade Desk, Raises Price Target to $92

Morgan Stanley analyst Nigel Dally maintains Prudential Financial (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PRU#NYSE">PRU</a>) with a Equal-Weight and raises the price target from $108 to $117.

Morgan Stanley Maintains Equal-Weight on Prudential Financial, Raises Price Target to $117

Lianhe Sowell International Shares Halted On Circuit Breaker To The Downside, Stock Now Down -27.2%

<a href="https://scr.zacks.com/files/News/2025/Zacks_SCR_Research_05192025_RANI_Vandermosten.pdf" title="https://scr.zacks.com/files/News/2025/Zacks_SCR_Research_05192025_RANI_Vandermosten.pdf">https://scr.zacks.com/files/News/2025/Zacks_SCR_Research_05192025_RANI_Vandermosten.pdf</a>

RANI

Watching Rani Therapeutics; Zacks Small-Cap Research Gives Stock $12 Price Valuation

Morgan Stanley analyst Bob Huang maintains Principal Financial Group (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PFG#NASDAQ">PFG</a>) with a Underweight and raises the price target from $67 to $71.

Morgan Stanley Maintains Underweight on Principal Financial Group, Raises Price Target to $71

Morgan Stanley analyst Bob Huang maintains Primerica (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PRI#NYSE">PRI</a>) with a Equal-Weight and raises the price target from $274 to $296.

Morgan Stanley Maintains Equal-Weight on Primerica, Raises Price Target to $296

Press Releases

Bicara Therapeutics to Present at the Stifel 2024 Healthcare Conference

Bicara Therapeutics Reports Third Quarter 2024 Financial Results and Provides Business Update

Health Care

Bicara Therapeutics Presents Phase 1/1b Dose Expansion Results with Ficerafusp Alfa in Advanced Squamous Cancer of the Anal Canal at the 2025 ASCO Gastrointestinal Cancers Symposium

Bicara Therapeutics Announces First Patients Enrolled in FORTIFI-HN01, a Pivotal Phase 2/3 Clinical Trial of Ficerafusp Alfa in 1L Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Bicara Therapeutics to Present at the TD Cowen 45th Annual Health Care Conference

Bicara Therapeutics Announces Upcoming Presentations at AACR Annual Meeting 2025

Bicara Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Provides Business Update

Bicara Therapeutics to Present Updated Data from Ongoing Phase 1/1b Trial of Ficerafusp alfa in 1L R/M HNSCC at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting

Bicara Therapeutics Highlights Broad Potential of Ficerafusp Alfa at AACR Annual Meeting 2025

Bicara Therapeutics Reports First Quarter 2025 Financial Results and Provides Business Update

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