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Vincerx Pharma

Vincerx Pharma Inc is a clinical-stage biopharmaceutical company focused on development and oncology expertise to advance new therapies intended to address unmet medical needs for the treatment of cancer. The company's activities are conducted in the United States. It focuses on developing, using, manufacturing, commercializing, sublicensing, and distributing a clinical-stage and follow-on small molecule drug program and a preclinical-stage bioconjugation/next-generation ADC platform.

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Acciones de Venus Concept (VERO) se disparan un 200%; aquí están 20 acciones que se mueven en premercado

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Explora los movimientos más destacados del pre-mercado, incluyendo el aumento del 23% en Logility y más sorpresas.

Acciones de Logility Supply Chain (LGTY) suben un 23%; 20 acciones que se mueven en el premercado de EE.UU.

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Descubre los mayores ganadores y perdedores en el mercado previo tras movimientos impactantes en acciones clave hoy.

Las acciones de Vincerx Pharma (VINC) suben alrededor del 64%; 20 acciones que se mueven en premercado

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Shares of BigBear.ai Holdings Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BBAI#NYSE">BBAI</a>) are soaring Monday morning, continuing a period of intense volatility, seemingly driven by recent company developments. Here&#8217;s what investors <a href="https://www.benzinga.com/quote/BBAI/news">need to know</a>.
What To Know: The momentum builds on several <a href="https://www.benzinga.com/trading-ideas/movers/25/06/46080056/bigbear-ai-bbai-stock-soars-21-whats-going-on">key announcements</a> from June. The company, which specializes in AI-powered decision intelligence, confirmed the deployment of its biometric passenger processing software at major international airports, including JFK and LAX. 
This deployment, a product of its Pangiam acquisition, is in partnership with U.S. Customs and Border Protection to streamline arrivals. 
Earlier in the month, BigBear.ai also <a href="https://www.benzinga.com/markets/equities/25/06/46090765/bigbear-ais-surges-over-25-amid-defense-contracts-airport-deployments-and-short-squeeze-hype">announced</a> a strategic partnership with Easy Lease PJSC to accelerate its expansion into the United Arab Emirates, a move CEO Kevin McAleenan called a "major first step" internationally.
Driving Monday's sharp price increase is the stock's market structure. With a substantial short interest representing 44.85% of the available float, the stock is a prime candidate for a short squeeze. 
This phenomenon occurs when a rapid price increase forces bearish investors to buy back shares to cover their positions, further fueling the upward rally and attracting high retail investor interest.
Price Action: According to data from&nbsp;<a href="https://benzinga.grsm.io/register174">Benzinga Pro</a>, BBAI is trading up nearly 20% to $6.99 Monday morning. BBAI has a 52-week high of $10.36 and a 52-week low of $1.16.
Read Also: <a href="https://www.benzinga.com/pressreleases/25/06/b45972242/bigbear-ai-deploys-enhanced-passenger-processing-biometric-technology-at-major-ports-of-entry-incl">BigBear.ai Deploys Enhanced Passenger Processing Biometric Technology at Major Ports of Entry, including U.S. and International Airports</a>
<h2 class="wp-block-heading">How To Buy BBAI Stock</h2>
By now you're likely curious about how to participate in the market for BigBear.ai &#8211; be it to purchase shares, or even attempt to bet against the company.
Buying shares is typically done through a brokerage account. You can find a list of <a href="https://www.benzinga.com/money/best-stock-trading-platforms">possible trading platforms here.</a> Many will allow you to buy &#8220;fractional shares,&#8221; which allows you to own portions of stock without buying an entire share.
In the case of BigBear.ai, which is trading at $7.06 as of publishing time, $100 would buy you 14.16 shares of stock.
If you're looking to bet against a company, the process is more complex. You'll need access to an options trading platform, or a broker who will allow you to &#8220;go short&#8221; a share of stock by lending you the shares to sell. The process of shorting a <a href="https://www.benzinga.com/money/how-to-short-a-stock">stock can be found at this resource.</a> Otherwise, if your broker allows you to trade options, you can either buy a put option, or sell a call option at a strike price above where shares are currently trading &#8211; either way it allows you to profit off of the share price decline.
Image: Shutterstock

BBAI

BigBear.ai (BBAI) Stock Is Up 20%: What's Going On?

The<a href="https://www.benzinga.com/markets/large-cap/25/06/46142591/apples-f1-movie-burns-300-million-still-waiting-on-a-profit"> highly anticipated</a> "F1" movie dominated the box office weekend and could be a rare theatrical hit for tech giant Apple Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AAPL#NASDAQ">AAPL</a>).
Here's a look at how the film stacks up versus other Apple theatrical releases and why its success is important.
What Happened: Starring Brad Pitt, "F1" topped the box office weekend with $55.6 million domestically and $144 million worldwide.
The film is estimated to have a budget of $250 million to $300 million, as reported by <a href="https://variety.com/2025/film/box-office/brad-pitt-f1-movie-box-office-record-apple-megan-2-flops-1236443608/">Variety</a>.
"We're thrilled by the global response to ‘F1' and grateful to the audiences who've embraced the film with such enthusiasm," Apple's head of worldwide video, Jamie Erlicht, said. "This success is a testament to the vision of Joe (Kosinski), Jerry (Bruckheimer), Brad, and Lewis (Hamilton), along with the efforts of the entire cast and crew. Together with Formula 1, they've created an inspiring cinematic journey that captures the energy and spirit of the sport."
Box office estimates projected the film to gross $50 million to $60 million domestically during its opening weekend. The movie opened past the halfway point of that range and international totals from 78 markets likely outperformed estimates.
New estimates suggest the film will gross $500 million to $600 million worldwide, as reported by 9to5Mac. To put that range into perspective, "F1" could not only be the top-grossing Apple film ever, but also make more than all the other Apple theatrical releases combined.
Here are the past four Apple films released in theaters, with the opening and total worldwide box office.
<ul class="wp-block-list">
<li>"Killers of the Flower Moon": $44 million opening, $158 million total</li>
<li>"Napoleon": $78 million opening, $221 million total</li>
<li>"Argylle": $35 million opening, $96 million total</li>
<li>"Fly Me to the Moon": $19 million opening, $42 million total</li>
</ul>
Barring any setbacks, "F1" will become the highest-grossing Apple film. If the film can gross $517 million worldwide at the box office, it would surpass the total earnings of all other Apple films combined.
Read Also: <a href="https://www.benzinga.com/markets/tech/25/06/45898644/tim-cook-explains-why-apples-f1-movie-bet-with-lewis-hamilton-serve-more-than-just-iphone-sales">Tim Cook Explains Why Apple&#8217;s &#8216;F1&#8217; Movie Bet With Lewis Hamilton Serves More Than Just iPhone Sales</a>
Why It's Important: Apple has released a limited number of original films in theaters with<a href="https://www.benzinga.com/24/03/37558754/apples-1b-gamble-on-3-blockbusters-analyzing-box-office-results-streaming-impact-and-oscar-nominatio"> minimal success </a>at the box office. None of the four movies above has made a profit.
Instead, the films have proven to be a marketing push for the company's Apple TV+ streaming platform. With "F1" doing well at the box office, it could mark the tech giant's first profitable theatrical film and also help the streaming platform down the road when the film becomes available on streaming.
Without a distribution arm, Apple relies on partners and must pay upfront fees and a portion of the box office revenue. In this case, that means Warner Bros. Discovery (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WBD#NASDAQ">WBD</a>) will also benefit from the strong showing of "F1" at theaters.
Premium movie theater company IMAX Corp. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/IMAX#NYSE">IMAX</a>) could also benefit from fans rushing to see the film on its larger screens. Imax and premium formats made up 55% of domestic ticket sales. Imax made up $27.7 million of the total global box office, or around 19%.
"With the most realistic racing sequences ever committed to film, ‘F1: The Movie' quite simply demands to be experienced in Imax, and audiences around the world clearly got that message," Imax CEO Rich Gelfond said.
Overall, the success of the film could be beneficial for the Formula 1 racing league, which is publicly traded as Liberty Formula One (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/FWONA#NASDAQ">FWONA</a>) (NASDAQ: FWONK). The racing league, which has been popular in international markets, has gained popularity in the US thanks to a docuseries on Netflix Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NFLX#NASDAQ">NFLX</a>).
Netflix and The Walt Disney Company (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DIS#NYSE">DIS</a>) could also benefit from the movie, with Netflix having the docuseries and Disney's ESPN having U.S. media rights. There have been reports that Apple has also explored acquiring global rights to the racing league in the future.
"F1" ranks well with an A grade on Cinemascore, 7.9 rating on <a href="https://www.imdb.com/title/tt16311594/">IMDb</a>, 83% Tomatometer from <a href="https://www.rottentomatoes.com/m/f1_the_movie">critics </a>on Rotten Tomatoes and a 97% Popcornmeter rating from viewers on Rotten Tomatoes.
Continued excitement and box office success for the film could help Apple and several other companies.
Read Next: 
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<li><a href="https://www.benzinga.com/general/entertainment/24/12/42750888/top-anticipated-2025-movies-for-big-screen-success-and-stocks-investors-should-watch">Top Anticipated 2025 Movies For Big Screen Success And Stocks Investors Should Watch</a></li>
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Photo: Shutterstock

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Apple's 'F1' Movie Soars At Box Office, Could Outgross Tech Giant's Previous Theatrical Films Combined

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Robinhood shares are trading higher. The company announced the launch of stock tokens and said it will expand tokenized trading in the US.

Bitcoin (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/btc/usd">BTC</a>) 2025 run may just be the beginning, according to seasoned analyst Bob Loukas, who sees a unique confluence of factors aligning to drive a potentially <a href="https://www.benzinga.com/money/bitcoin-price-prediction">extended bull cycle through 2026.</a>
What Happened: In the latest <a href="https://www.youtube.com/watch?v=lFyXznUq30A&amp;t=688s">episode</a> of his podcast "Bitcoin 4 Year Cycle Journey" on June 27, Loukas shared a bold outlook: Bitcoin is on track for a "double cycle blowoff", a rare scenario where the ongoing cycle doesn&#8217;t end with a typical top but instead continues into the early phase of a new cycle, resulting in one extended mega-cycle.
Now about 31 months into Bitcoin's four-year halving cycle, with the traditional peak near month 35, Loukas noted this cycle has been remarkably stable, with only shallow drawdowns of 20%–30%. 
This, he suggests, is due to stronger institutional participation cushioning the volatility that previously dominated crypto bull markets.
&#8220;We haven't seen the kind of euphoric blow-off sentiment that usually marks a cycle top," Loukas said, hinting that Bitcoin's most explosive phase may still be ahead.
Also Read: <a href="https://www.benzinga.com/crypto/cryptocurrency/25/06/46166208/bitcoin-etfs-extend-record-2-2b-net-inflows-to-extend-streak-to-11-weeks">Bitcoin ETFs Extend Record $2.2B Net Inflows To Extend Streak To 11 Weeks</a>
Why It Matters: Loukas believes Bitcoin's "perfect storm" is being fueled by:
<ul class="wp-block-list">
<li>Massive inflows into spot Bitcoin ETFs, now surpassing $2.2B in net inflows over 11 consecutive weeks.</li>
<li>Corporate treasury adoption, following Strategy's lead.</li>
<li>A shift in institutional stance, with TradFi banks and wealth funds increasingly pro-BTC.</li>
<li>The Trump administration's pro-crypto policy framework, setting the stage for regulatory clarity and growth.</li>
</ul>
"These catalysts didn't even exist 18 months ago," he added, underscoring how new capital inflows are reshaping Bitcoin's market structure.
His &#8220;double cycle blowoff&#8221; theory suggests the bull market could extend into February or March 2026, followed by a shorter-than-usual bear market, then a swift launch into the next bull phase, creating an illusion of one extended cycle.
What's Next: From a technical lens, Loukas sees Bitcoin potentially doubling from the current $107,000–$110,000 zone if it reclaims recent highs and enters true price discovery. Historically, new highs during this phase lead to sharp gains over 3–5 months.
While Loukas didn't offer a firm target, he floated the possibility of BTC reaching $250,000 or more during the full mania phase: "A 5x, 6x, even 7x move from here over a couple years in a speculative blow-off isn't unrealistic."
He also highlighted how retail demand, including 401(k) self-directed capital, could flood the market once institutions and sovereign wealth funds push the next leg up.
Read Next:
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/crypto/cryptocurrency/25/06/46165655/bitcoin-ethereum-xrp-dogecoin-start-monday-flat-as-traders-hope-for-bullish-july">Bitcoin, Ethereum, XRP, Dogecoin Start Monday Flat As Traders Hope For Bullish July</a></li>
</ul>
Image: Shutterstock

Coverage of Bitcoin, Etherum, Ripple and all the latest digital currencies.

Cryptocurrency

$BTC

Bitcoin's 'Perfect Storm' Could Extend Bull Run Into 2026: Report

MSCI (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MSCI#NYSE">MSCI</a>) has outperformed the market over the past 15 years by 9.48% on an annualized basis producing an average annual return of 22.16%. Currently, MSCI has a market capitalization of $44.60 billion. 
Buying $1000 In MSCI: If an investor had bought $1000 of MSCI stock 15 years ago, it would be worth $20,123.60 today based on a price of $576.41 for MSCI at the time of writing.
<h3>MSCI's Performance Over Last 15 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1751297412_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

MSCI

Here's How Much You Would Have Made Owning MSCI Stock In The Last 15 Years

U.S. stocks were higher, with the Dow Jones index gaining over 100 points on Monday.
Shares of Hewlett Packard Enterprise Company (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HPE#NYSE">HPE</a>) gained 13.3% to $20.85.
Hewlett Packard Enterprise and Juniper Networks, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/JNPR#NYSE">JNPR</a>) reached an agreement with the U.S. <a href="https://www.benzinga.com/quote/HPE">Department of Justice (DOJ) on Saturday.</a>
This settlement, subject to court approval, resolves the DOJ's lawsuit that challenged HPE's acquisition of Juniper and paves the way for the transaction to close.
Hewlett Packard Enterprise shares jumped 13.3% to $20.85 on Monday.
Here are some other big stocks recording gains in today&#8217;s session.
<ul class="wp-block-list">
<li>New Fortress Energy Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NFE#NYSE">NFE</a>) shares jumped 33.2% to $3.3288.</li>
<li>Greenlane Holdings, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GNLN#NASDAQ">GNLN</a>) gained 24.1% to $3.8206. Greenlane Holdings announced the appointment of Mike Hinson as the Company&#8217;s Executive Vice President of Sales.</li>
<li>BigBear.ai Holdings, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BBAI#NYSE">BBAI</a>) surged 20.8% to $7.06.</li>
<li>Ginkgo Bioworks Holdings, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/DNA#NYSE">DNA</a>) gained 19.2% to $11.27.</li>
<li>Joby Aviation, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/JOBY#NYSE">JOBY</a>) rose 17% to $11.04 after the company announced it completed a series of test flights in Dubai.</li>
<li>Ondas Holdings Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ONDS#NASDAQ">ONDS</a>) gained 15.5% to $2.1146.</li>
<li>Magnite, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MGNI#NASDAQ">MGNI</a>) rose 14.1% to $24.08 after Rosenblatt raised its price target on the stock from $18 to $39.</li>
<li>Newsmax, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NMAX#NYSE">NMAX</a>) jumped 13.1% to $15.05.</li>
<li>Eos Energy Enterprises, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EOSE#NASDAQ">EOSE</a>) gained 13.1% to $4.9852.</li>
<li>GMS Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GMS#NYSE">GMS</a>) gained 11.6% to $108.76 after the company announced it will be acquired by a Home Depot subsidiary for $5.5 billion.</li>
<li>Rezolve AI PLC (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RZLV#NASDAQ">RZLV</a>) rose 11.5% to $3.0550.</li>
<li>Dave Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DAVE#NASDAQ">DAVE</a>) gained 9% to $272.08 after Benchmark raised its price target on the stock from $229 to $320.</li>
<li>Bloom Energy Corporation (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BE#NYSE">BE</a>) rose 7% to $23.71.</li>
<li>Reddit, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/RDDT#NYSE">RDDT</a>) gained 6.2% to $151.83.</li>
</ul>
Now Read This: 
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<li><a href="https://www.benzinga.com/trading-ideas/dividends/25/06/46168575/wall-streets-most-accurate-analysts-spotlight-on-3-defensive-stocks-delivering-high-dividend-yields-4">Wall Street&#8217;s Most Accurate Analysts Spotlight On 3 Defensive Stocks Delivering High-Dividend Yields</a> </li>
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Hewlett Packard Enterprise, Magnite, GMS And Other Big Stocks Moving Higher On Monday

<a href="https://www.youtube.com/watch?v=FBHmAq5lmZQ">https://www.youtube.com/watch?v=FBHmAq5lmZQ</a>
&nbsp;

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Xinyuan Real Estate Co Shares Halted, News Pending

– AI-driven speech to text wearable transcription enhances accessibility for the deaf or hard of hearing, delivering real-time closed captions in nearly any environment &nbsp;
ROCHESTER, N.Y., June 30, 2025 /PRNewswire/ --&nbsp;Vuzix&#xAE; Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/VUZI#NASDAQ">VUZI</a>) ("Vuzix" or the "Company"), a leading supplier of smart glasses, waveguides and augmented reality (AR) technology today announced that <a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4459761-1&amp;h=848735028&amp;u=https%3A%2F%2Fwww.transcribeglass.com%2F&amp;a=TranscribeGlass">TranscribeGlass</a>, a Connecticut-based company specializing in real-time speech-to-text transcription solutions, is continuing to place follow-on orders for Vuzix Z100 smart glasses to support increasing demand for its AI-powered real-time transcription service.
TranscribeGlass is built to improve accessibility for individuals who are deaf or hard of hearing by using AI to deliver real-time speech-to-text transcription with latency under 300 milliseconds, ensuring rapid and reliable captioning. The device connects via Bluetooth to a user's existing smartphone or tablet and performs effectively in both quiet and noisy environments. Advanced speaker identification further enhances usability, making it easier to follow conversations in group settings.

Contracts

VUZI

Vuzix Receives Follow-On Orders For Z100 Smart Glasses As Demand Grows For TranscribeGlass AI Speech-To-Text Accessibility Solution

Greenlane Holdings Shares Resume Trading

Vanguard International Semiconductor (VIS), an affiliate of Taiwan Semiconductor Manufacturing Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TSM#NYSE">TSM</a>), is <a target="_blank" href="https://www.benzinga.com/topic/semiconductors" rel="noreferrer noopener">exploring an accelerated timeline</a> for its new $7.8 billion 300-millimeter chip plant in Singapore amid escalating geopolitical tensions and calls for supply chain diversification.
This move, driven by a surge in demand and China&#8217;s persistent threats towards Taiwan, aims to bring the facility online by late 2026, ahead of its initial mid-2027 schedule, Bloomberg <a target="_blank" href="https://www.bloomberg.com/news/articles/2025-06-28/tsmc-affiliate-vis-may-expedite-production-at-8-billion-singapore-fab?sref=TBDibEcD" rel="noreferrer noopener">reported</a> on Saturday, citing Chairman&nbsp;Fang Leuh at a company event.
The <a target="_blank" href="https://www.benzinga.com/news/24/06/39190595/tsmc-backed-vanguard-nxp-plan-on-building-7-8b-semiconductor-facility-in-singapore" rel="noreferrer noopener">joint venture</a> with Dutch firm NXP Semiconductors (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NXPI#NASDAQ">NXPI</a>) is a strategic step for both companies to secure chip supply for the automotive and industrial sectors.
Also Read: <a target="_blank" href="https://www.benzinga.com/government/regulations/25/04/44713681/taiwan-semi-could-face-more-than-1-billion-in-us-penalty-over-alleged-huawei-chip-link-reuters" rel="noreferrer noopener">Taiwan Semi Could Face More Than $1 Billion In US Penalty Over Alleged Huawei Chip Link: Reuters</a>
Reportedly, Vanguard International Semiconductor <a target="_blank" href="https://www.benzinga.com/news/24/06/39190595/tsmc-backed-vanguard-nxp-plan-on-building-7-8b-semiconductor-facility-in-singapore" rel="noreferrer noopener">contributed $2.4 billion</a>, securing a 60% equity stake in the initiative, while NXP invested $1.6 billion for a 40% stake. Both companies contributed an additional $1.9 billion each. The venture aimed for an estimated monthly output of 55,000 300mm wafers by 2029.
Vanguard International Semiconductor broke ground for the Singapore facility in the fourth quarter of 2024. Fang told Bloomberg that Vanguard International Semiconductor prioritized the readiness of its first plant. He expects Vanguard International Semiconductor to grow mildly in U.S. dollar terms year-over-year in the second half.
U.S. trade policies, specifically the Trump administration&#8217;s <a target="_blank" href="https://www.benzinga.com/government/regulations/25/05/45508534/taiwan-minister-shrugs-off-us-tariffs-says-taiwan-semiconductor-will-thrive-while-samsung-takes-the-hit" rel="noreferrer noopener">&#8220;reciprocal&#8221; tariff plans</a> from April 2025 (which included duties of 32%, 25%, and 24% on goods from Taiwan, South Korea, and Japan, aiming to spur U.S. manufacturing), also contributed to companies proactively stocking up on chips. While this policy was paused shortly after its announcement, it underscored the need for supply chain resilience.
Despite U.S. tariff discussions, Taiwan&#8217;s Minister of Economic Affairs, J.W. Kuo, stated in May that Taiwanese chipmakers remain largely unfazed, citing America&#8217;s significant dependence on Taiwan for expanding its chip production capabilities.
He further asserted that Taiwan Semiconductor would maintain its competitive edge for the next decade, with any tariff increases primarily impacting American customers rather than the company directly.
Price Action:&nbsp;TSM stock is down 1.30% at $225.59 at the last check on Monday.
Read Next:
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/25/04/44857887/taiwan-semiconductor-q1-surges-41-in-sales-boosted-by-ai-chip-demand-expanded-margins" target="_blank" rel="noreferrer noopener">Taiwan Semiconductor CFO Anticipates Tariffs Impact But Has Not Seen Change In Customer Behavior Yet, Issues Strong Q2 Outlook</a></li>
</ul>
Image via Shutterstock

Tech

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Taiwan Semiconductor's Affiliate Fast-Tracks Singapore Plant Spurred By Geopolitics

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– The Launch-HTN trial is the largest trial of an aldosterone synthase inhibitor completed in participants with uncontrolled or treatment resistant hypertension –
– Lorundrostat 50 mg once daily demonstrated clinically meaningful reductions in systolic blood pressure, with a 16.9 mmHg reduction at Week 6 and a 19.0 mmHg reduction at Week 12 –
– Lorundrostat was generally well-tolerated; and treatment-emergent adverse events were mostly mild, transient, and resolved without intervention –
RADNOR, Pa., June 30, 2025 (GLOBE NEWSWIRE) -- Mineralys Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MLYS#NASDAQ">MLYS</a>), a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension, chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone, today announced the publication of the positive results from the pivotal Phase 3 Launch-HTN trial in the Journal of the American Medical Association (JAMA). The manuscript titled "Lorundrostat in Participants with Uncontrolled and Treatment-Resistant Hypertension" is featured in the June 30, 2025 issue.
The Launch-HTN trial evaluated the efficacy and safety of lorundrostat, a novel aldosterone synthase inhibitor (ASI), when added to existing background treatment in 1,083 participants with uncontrolled or treatment resistant hypertension. The trial demonstrated that lorundrostat significantly reduced systolic blood pressure (BP) with a favorable safety and tolerability profile.

Biotech

General

MLYS

Mineralys' Lorundrostat Achieves Clinically Meaningful Blood Pressure Reductions In Landmark Phase 3 Launch-HTN Trial; Results Published In JAMA

A sharp decline in the U.S. dollar is reigniting investor interest in emerging markets, prompting billions to flow into investment products tracking equities, despite Wall Street dominating headlines <a href="https://www.benzinga.com/markets/equities/25/06/46163305/sp-hits-record-high-amid-easing-trade-tensions-investor-sentiment-improves-fear-index-remains-in-greed-zone">with new all-time highs.</a>
The iShares Core MSCI Emerging Markets ETF (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/IEMG#NYSE">IEMG</a>)—the top vehicle for U.S. investors seeking exposure to EM equities—registered $2.95 billion in inflows in June, its strongest monthly influx since January 2023. 
Emerging market stocks are on track for a 5% monthly gain in both May and June, setting up the strongest two-month performance since late 2022.
The surge marks a significant shift in global positioning, particularly as investors seek relative value and macro tailwinds beyond U.S. assets, with the U.S. Dollar Index (DXY) dropping to its lowest level in over three years.
<figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="1024" height="528" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101209/image-441-1024x528.png" alt="" class="wp-image-967042" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101209/image-441-1024x528.png 1024w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101209/image-441-300x155.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101209/image-441-768x396.png 768w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101209/image-441-1536x792.png 1536w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101209/image-441-2048x1056.png 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure>
<h2 class="wp-block-heading">Weaker Dollar Reshapes Emerging Markets</h2>
Bank of America's chief investment strategist Michael Hartnett sees a powerful confluence of global forces working in favor of emerging markets. 
In his recent note, the analyst said the rise of artificial intelligence is increasing demand for the raw materials that many EM countries produce, while a weakening U.S. dollar is removing one of the main barriers to capital inflows. 
With EM equities still trading near multi-decade lows relative to U.S. stocks, Hartnett suggested the current setup makes an &#8220;easy allocation decision.&#8221;
Emerging markets have underperformed U.S. stocks – as tracked by the SPDR S&amp;P 500 ETF Trust (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SPY#NYSE">SPY</a>) – by 70% since 2013, yet they&#8217;re up about 10% year-to-date—on track for their best year since 2017.
Chart: Emerging Markets Have Lagged US Stocks By 70% Since 2013
<figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="1024" height="528" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101933/image-443-1024x528.png" alt="" class="wp-image-967055" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101933/image-443-1024x528.png 1024w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101933/image-443-300x155.png 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101933/image-443-768x396.png 768w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101933/image-443-1536x792.png 1536w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/30101933/image-443-2048x1056.png 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure>
<h2 class="wp-block-heading">Positioning To EM Stocks Still Light </h2>
David Hauner, head of emerging markets strategy at Bank of America, reinforced the bank&#8217;s optimistic view on EM assets.
He has maintained a bullish stance since President Donald Trump's inauguration and sees room for further upside, as investor positioning remains lighter than expected—despite solid year-to-date gains and a broadly weaker U.S. dollar.
He added that while U.S. fiscal concerns are rising, the main risk for EM would be "an unexpected dollar rebound" from the upcoming trade talks.
Historically, emerging markets have been vulnerable to rising U.S. yields, especially on the long end of the curve. However, recent price action tells a different story. Despite higher 30-year Treasury yields, EM local bonds and currencies have remained resilient.
"As long as DXY is down, EM returns tend to stay positive—even when U.S. yields rise," said Hauner. 
Bank of America's historical data supports that view. Since 2008, when the Dollar Index declined, the MSCI Emerging Markets Index posted gains 72% of the time, with average monthly returns between 2.2% and 2.8%, depending on the movement in long-term U.S. yields.
<figure class="wp-block-table is-style-stripes"> 
<table class="has-fixed-layout">
<thead>
<tr>
<th>Scenario</th>
<th>MSCI EM Stocks Win Rate (Avg Return)</th>
<th>MSCI EM Currency Win Rate (Avg Return)</th>
</tr>
</thead>
<tbody>
<tr>
<td>DXY Down / 30Y Yield Up</td>
<td>72% (2.8%)</td>
<td>81% (1.1%)</td>
</tr>
<tr>
<td>DXY Down / 30Y Yield Down</td>
<td>74% (2.2%)</td>
<td>88% (1.1%)</td>
</tr>
<tr>
<td>DXY Up / 30Y Yield Up</td>
<td>42% (-1.4%)</td>
<td>35% (-0.5%)</td>
</tr>
<tr>
<td>DXY Up / 30Y Yield Down</td>
<td>39% (-1.5%)</td>
<td>35% (-0.5%)</td>
</tr>
</tbody>
</table>
<figcaption class="wp-element-caption">Data: Bank of America</figcaption></figure>
Read Next:
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/etfs/broad-u-s-equity-etfs/25/06/46166959/sp500-stocks-outlook-etf-analysis">This S&amp;P 500 ETF Saw A 30-Month Buying Spree — Now It&#8217;s Over </a></li>
</ul>
Image created using artificial intelligence via Midjourney.

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Emerging Markets

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IEMG

A Weaker Dollar Just Unlocked A Surprise 2025 Winner — And Smart Money Is Moving In

ORCL

Oracle shares are trading higher after the company's CEO provided bullish commentary on the company's trajectory for 2026. Additionally, Stifel upgraded the stock rom Hold to Buy and raised its price target from $180 to $250.

Oracle Corp (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ORCL#NYSE">ORCL</a>) shares are hitting new highs on Monday after the company&#8217;s CEO provided bullish commentary on the company&#8217;s trajectory <a href="https://www.benzinga.com/news/25/06/46166651/oracle-in-filing-says-ceo-plans-to-meet-with-other-oracle-colleagues-today-will-say-oracle-is-off-to">in a filing</a>. 
What Happened: Oracle CEO Safra Catz said in a SEC filing that Oracle is off to a &#8220;strong start&#8221; in fiscal 2026 as MultiCloud database revenue continues to experience over 100% growth. 
The filing comes ahead of a planned meeting with colleagues in which Catz plans to discuss &#8220;multiple large&#8221; cloud services agreements, including one agreement that is expected to drive more than $30 billion in annual revenue beginning in fiscal 2028. 
Oracle <a href="https://www.benzinga.com/markets/earnings/25/06/45893773/oracle-q4-earnings-revenue-eps-beat-estimates-cloud-infrastructure-growth-expected-to-accelerate-with-demand-skyrocketing">said</a> earlier this month that its MultiCloud database revenue from Amazon, Google and Azure grew 115% sequentially in the fourth quarter ended May 31. The company noted at the time that it expected to continue to see triple-digit MultiCloud revenue growth in fiscal 2026.
Oracle Cloud Infrastructure&nbsp;(OCI) consumption revenue also grew 62% in the quarter.
&#8220;OCI revenue growth rates are skyrocketing — so is demand," Oracle chair and CTO Larry Ellison said in the company&#8217;s earnings release.
Stifel analyst Brad Reback upgraded Oracle from <a href="https://www.benzinga.com/analyst-stock-ratings">Hold to Buy</a> and raised the price target from&nbsp;$180&nbsp;to&nbsp;$250 on Monday, which may be helping push shares to new highs. 
Stifel joins UBS and Guggenheim, who also recently increased price targets to $250, which is the Street-high forecast for Oracle. Oracle has a Street-low target of $160, according to Benzinga <a href="https://www.benzinga.com/quote/ORCL/analyst-ratings">analyst data</a>. 
ORCL Price Action: <a href="http://benzinga.com/quote/orcl">Oracle shares</a> were up 4.88% at $220.51 at the time of publication, according to <a href="http://pro.benzinga.com">Benzinga Pro</a>. Shares are now up approximately 33% on a year-to-date basis.
Read Next:
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/markets/tech/25/06/46163057/meta-is-gonna-need-time-to-catch-up-says-hyperbolic-cto-yuchen-jin-as-openais-upcoming-open-source-release-outperforms-existing-chatgpt-model">Meta Is &#8216;Gonna Need Time To Catch Up,&#8217; Says Hyperbolic CTO Yuchen Jin As OpenAI&#8217;s Upcoming Open-Source Release Outperforms Existing ChatGPT Model</a></li>
</ul>
Photo: Jonathan Weiss/Shutterstock.com

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Oracle Stock Hits All-Time High After CEO Flags 'Strong Start' To Fiscal 2026

Greenlane Holdings Shares Resume Trade

BitMine Immersion Technologies Shares Halted On Circuit Breaker To The Upside, Stock Now Up 517.1%

Raymond James analyst Justin Jenkins maintains Valero Energy (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/VLO#NYSE">VLO</a>) with a Strong Buy and raises the price target from $150 to $155.

Analyst Ratings

Raymond James Maintains Strong Buy on Valero Energy, Raises Price Target to $155

Press Releases

SHAREHOLDER NOTICE: Halper Sadeh LLC Investigates VINC, MHLD, NEUE on Behalf of Shareholders

Legal

Kuehn Law Encourages VINC, NEUE, GETY, and CLBR Investors to Contact Law Firm

SHAREHOLDER NOTICE: Halper Sadeh LLC Investigates GETY, CLBR, VINC, NEUE on Behalf of Shareholders

Vincerx Pharma, Inc. Announces Reverse Stock Split

Health Care

Vincerx Pharma, Inc. and Oqory, Inc. Highlight Promising Data for Oqory's TROP2 Antibody Drug Conjugate, OQY-3258

Vincerx Pharma Announces Termination of Reverse Merger Term Sheet and Evaluation of Strategic Alternatives

Vincerx Pharma Announces Non-Binding Letter of Intent for Business Combination with QumulusAI

Vincerx Pharma Announces Termination of Letter of Intent and Board Authorization to Pursue Wind-Down Activities

Vincerx Pharma, Inc. Announces Intent to Delist from Nasdaq and Deregister with the SEC

Vincerx Pharma, Inc. Announces Adjournment of Special Meeting - Will Reconvene Meeting on July 16, 2025 to Secure Votes Needed to Approve Dissolution Proposal

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