Últimas noticias sobre Sionna Therapeutics (NASDAQ:SION) Bolsa

Sionna Therapeutics

Sionna Therapeutics Inc is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (CF) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefit to CF patients. CF is a progressive and life-threatening genetic disease caused by inherited mutations in the CFTR gene, which heads to insufficient CFTR function. The Company is managed as one operating segment focused on the research and development of cystic fibrosis therapies.

Sionna Therapeutics Inc

Sionix Corp

Retailer Walmart Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/WMT#NYSE">WMT</a>) <a href="https://www.benzinga.com/markets/25/05/45536218/walmart-responds-to-trumps-eat-the-tariff-remark-worked-to-keep-our-prices-as-low-as-possible-and-we-wont-stop">has been battling</a> with the Donald Trump administration over tariffs and may have a new fight on its hands with Trump fans thanks to an heiress of the company's founding family.
What Happened: Walmart and the Trump administration have been going back and forth on tariffs and whether the retailer can publicly say it <a href="https://www.benzinga.com/news/retail-sales/25/06/45829026/walmart-shoppers-see-sharp-price-hikes-as-tariffs-hit-shelves">is passing costs </a>onto consumers.
An additional issue, which could possibly mean the retailer finds itself with fewer customers, is if it battles too hard with Trump fans due to Christy Walton.
Walton is the widow of John T. Walton, son of Walmart founder Sam Walton. The Walmart heiress funded a full-page ad for the "No Kings" movement placed in the New York Times, the New York Post <a href="https://nypost.com/2025/06/11/business/walmart-heiress-christy-waltons-anti-trump-ad-fuels-maga-led-call-for-boycott-of-retailer/">reported</a>.
The ad calls for a nationwide protest against Trump and asks Americans and other citizens to "mobilize" on Saturday, which is Trump's birthday and the day of a large military parade in the nation's capital.
Walton's funded ad also calls on Americans to "reject authoritarianism."
According to the report, the "No Kings" movement is planning around 1,500 nationwide protests on Saturday. The report notes that the movement is not holding a protest in Washington, D.C. on Saturday on purpose.
"The honor, dignity, and integrity of our country are not for sale," the ad reads, alongside a QR code that shows the map of protest locations.
A Christy Walton spokesperson said the ad does not encourage violent protests, but rather to "engage peacefully and civically."
"Christy has provided no funding to organizations or individuals involved in the demonstrations in Los Angeles or other cities, nor has she provided any funding to those organizing the upcoming events," the spokesperson said.
The spokesperson said Walton believes Americans have the right to protest, but not the right to violence.
Read Also: <a href="https://www.benzinga.com/news/politics/25/06/45894541/trump-sports-president-military-birthday-parade">Airtime Denied: Trump B-Day, Military Parade Gets Streaming Treatment</a>
Why It's Important: Walton is not involved in Walmart's operations, but her actions could end up hurting the future growth and revenue of the company her former husband's family founded. She maintains a 1.9% stake in the company.
Walton is worth $18.6 billion according to <a href="https://www.bloomberg.com/billionaires/?sref=TBDibEcD">Bloomberg</a>, ranking 117th among the world's billionaires. This trails other Walton figures like her son Lukas Walton, who is the 39th richest person worth $41.1 billion, and her husband's siblings Jim, Rob and Alice Walton, who rank 13th, 14th and 15th worth $119 billion, $117 billion and $116 billion, respectively.
The White House responded to the ad and brushed aside Walton's criticism.
"Great, a left-wing billionaire feels like burning some of her inheritance for a PR stunt," White House spokesman Kush Desai told The Post.
Desai said the ad would not change the fact that more than 77 million Americans voted for Trump and his "America First trade policies."
Some Trump allies indirectly and directly called for a boycott of Walmart.
White House special adviser Kari Lake shared the ad on X and asked her followers, "Do you shop at Walmart?"
Rep. Anna Paulina Luna (R-Fla.) posted on X that Walton is funding ads for "No Kings Day," while naming her as a Walmart heiress.
"Looks like the Walmart dynasty is big mad about China tariffs," Luna said.
Trump supporter Roger Stone encouraged people to boycott Walmart.
"The Walmart heiress subsidizes insurrection. Next up, peaceful protests outside all of their stores to encourage people not to shop there. Essentially what left-wing stooges did to Tesla," Stone said.
Walmart has tried to distance itself from Walton.
"The advertisement from Christy Walton [is] in no way connected to or endorsed by Walmart," Walmart spokesperson Joe Pennington said.
Pennington said Walton "has no active role in company decisions."
This could end up being an unfortunate situation for Walmart and shareholders as a major boycott effort by Trump fans could impact sales. Walmart locations are often times found in rural locations and small cities that have leaned towards voting for Trump in recent elections.
WMT Price Action: Walmart stock closed down 1.01% to $94.83 on Thursday versus a 52-week trading range of $65.95 to $105.30. Walmart stock is up 5.4% year-to-date in 2025.
Read Next: 
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/news/management/25/05/45473067/walmart-prices-will-rise-within-weeks-as-trump-tariffs-drive-up-costs-will-other-retailers-follow-suit">Walmart Prices Will Rise Within Weeks As Trump Tariffs Drive Up Costs: Will Other Retailers Follow Suit?</a></li>
</ul>
Photo: Shutterstock

Politics

Trading Ideas

Walmart Heiress Takes On Trump With 'No Kings' Ad: White House Calls It 'Burning Some Of Her Inheritance For A PR Stunt'

ServiceNow (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NOW#NYSE">NOW</a>) has outperformed the market over the past 5 years by 6.34% on an annualized basis producing an average annual return of 20.38%. Currently, ServiceNow has a market capitalization of $208.81 billion. 
Buying $100 In NOW: If an investor had bought $100 of NOW stock 5 years ago, it would be worth $256.65 today based on a price of $1008.00 for NOW at the time of writing.
<h3>ServiceNow's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1749766512_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

News

Here's How Much $100 Invested In ServiceNow 5 Years Ago Would Be Worth Today

General

CLDX

Celldex Therapeutics Announces 76-Week Results From Barzolvolimab Phase 2 Study In Chronic Spontaneous Urticaria At EAACI Congress 2025; Up To 41% Of Patients Reporting A Complete Response At 76 Weeks And 48% Of Patients Reporting That Their Disease No Longer Impacts Their Quality Of Life; Enrollment to Phase 3 CSU Trials Ongoing

BPMC

Blueprint Medicines Reveals Data Reinforcing Sustained Clinical Efficacy And Well-Tolerated Safety Profile of Long-Term AYVAKIT/AYVAKYT Treatment At 2025 EHA And EAACI Congresses

WIIM

ADBE

ADBE stock has given up its prior gain. Adobe shares were trading higher after the company reported better-than-expected Q2 financial results and raised its FY25 guidance.

<a href="https://www.bloomberg.com/news/articles/2025-06-12/nrg-expects-to-line-up-new-us-data-center-deals-this-quarter?embedded-checkout=true">https://www.bloomberg.com/news/articles/2025-06-12/nrg-expects-to-line-up-new-us-data-center-deals-this-quarter?embedded-checkout=true</a>

'NRG Expects to Line Up New US Data Center Deals This Quarter'- Bloomberg

In the current market session, ServiceNow Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NOW#NYSE">NOW</a>) share price is at $1008.00, after a 0.37% increase. Moreover, over the past month, the stock decreased by 2.69%, but in the past year, went up by 38.26%. Shareholders might be interested in knowing whether the stock is overvalued, even if the company is performing up to par in the current session. 

<img src="https://www.benzinga.com/files/images/story/2025/1749765619_0.png" alt="Past Year Chart" />

<h3>A Look at ServiceNow P/E Relative to Its Competitors</h3>
The P/E ratio measures the current share price to the company's EPS. It is used by long-term investors to analyze the company's current performance against it's past earnings, historical data and aggregate market data for the industry or the indices, such as S&amp;P 500. A higher P/E indicates that investors expect the company to perform better in the future, and the stock is probably overvalued, but not necessarily. It also could indicate that investors are willing to pay a higher share price currently, because they expect the company to perform better in the upcoming quarters. This leads investors to also remain optimistic about rising dividends in the future. 
ServiceNow has a better P/E ratio of 136.27 than the aggregate P/E ratio of 92.8 of the Software industry. Ideally, one might believe that ServiceNow Inc. might perform better in the future than it's industry group, but it's probable that the stock is overvalued. 

<img src="https://www.benzinga.com/files/images/story/2025/1749765619_1.png" alt="Guage" />

In conclusion, the price-to-earnings ratio is a useful metric for analyzing a company's market performance, but it has its limitations. While a lower P/E can indicate that a company is undervalued, it can also suggest that shareholders do not expect future growth. Additionally, the P/E ratio should not be used in isolation, as other factors such as industry trends and business cycles can also impact a company's stock price. Therefore, investors should use the P/E ratio in conjunction with other financial metrics and qualitative analysis to make informed investment decisions.

Intraday Update

Markets

Price Over Earnings Overview: ServiceNow

UBS Gr (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UBS#NYSE">UBS</a>) has outperformed the market over the past 5 years by 10.05% on an annualized basis producing an average annual return of 24.1%. Currently, UBS Gr has a market capitalization of $104.08 billion. 
Buying $1000 In UBS: If an investor had bought $1000 of UBS stock 5 years ago, it would be worth $2,986.29 today based on a price of $32.67 for UBS at the time of writing.
<h3>UBS Gr's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1749765613_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

$1000 Invested In This Stock 5 Years Ago Would Be Worth This Much Today

<a href="https://www.axios.com/2025/06/12/israel-strike-iran-us-not-participate">https://www.axios.com/2025/06/12/israel-strike-iran-us-not-participate</a>

iShares MSCI Israel Capped Investable Market Index Fund

'U.S. told Israel it won't participate in an Israeli strike on Iran'- Axios

Offerings

XTIA

XTI Aerospace Files For Firm Commitment Public Offering Of Up To 3.96M Shares Of Common Stock

Earnings

Friedman Industries Q4 EPS $0.76 Up From $0.71 YoY, Sales $129.22M Down From $132.23M YoY

Intercontinental Exchange (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ICE#NYSE">ICE</a>) has outperformed the market over the past 15 years by 2.3% on an annualized basis producing an average annual return of 14.2%. Currently, Intercontinental Exchange has a market capitalization of $102.89 billion. 
Buying $100 In ICE: If an investor had bought $100 of ICE stock 15 years ago, it would be worth $731.95 today based on a price of $179.08 for ICE at the time of writing.
<h3>Intercontinental Exchange's Performance Over Last 15 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1749763821_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

If You Invested $100 In This Stock 15 Years Ago, You Would Have This Much Today

<a href="https://www.wsj.com/world/middle-east/israel-attack-iran-nuclear-program-ac023cd5?mod=hp_lead_pos1">https://www.wsj.com/world/middle-east/israel-attack-iran-nuclear-program-ac023cd5?mod=hp_lead_pos1</a>

'Israeli Attack on Iran Could Come Within Days, U.S. and Israeli Officials Say'- WSJ

DKNG

DraftKings To Introduce Transaction Fee In Illinois; To Implement 50c Deal Fee On Illinois Bets

QNCX

Quince Therapeutics Reveals Pricing Of Up To $22M Private Placement Of Securities; Financing To Provide $11.5M Upfront, $10.4M From Warrants; Proceeds To Fund Phase 3 Neat Trial And Corporate Purposes

BJ's Wholesale Club Hldgs (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BJ#NYSE">BJ</a>) has outperformed the market over the past 5 years by 11.42% on an annualized basis producing an average annual return of 25.47%. Currently, BJ's Wholesale Club Hldgs has a market capitalization of $14.48 billion. 
Buying $1000 In BJ: If an investor had bought $1000 of BJ stock 5 years ago, it would be worth $3,237.67 today based on a price of $109.66 for BJ at the time of writing.
<h3>BJ's Wholesale Club Hldgs's Performance Over Last 5 Years</h3>
<img src="https://www.benzinga.com/files/images/story/2025/1749762911_0.png" alt="comp_fig" />
Finally -- what's the point of all this? The key insight to take from this article is to note how much of a difference compounded returns can make in your cash growth over a period of time.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Here's How Much $1000 Invested In BJ's Wholesale Club Hldgs 5 Years Ago Would Be Worth Today

While the wider business community awaited news regarding <a href="https://www.benzinga.com/news/macro-notification/25/06/45876366/howard-lutnick-says-us-and-china-reached-a-framework-to-implement-geneva-consensus-following-trump-xi-call-csi-300-index-gains">trade negotiations</a> between the U.S. and China, one of the more anxious names may have been Applied Materials Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AMAT#NASDAQ">AMAT</a>). As a semiconductor equipment specialist, Applied Materials represents a vital cog for multiple tech sectors, including computers, smartphones and solar products. However, tensions between the world's top two economies threatened the company's access to critical rare earth minerals.
To be sure, the immediate response to the new trade deal framework — announced on Tuesday following two days of high-level discussions between U.S. and Chinese officials — was muted. While analysts in principle are encouraged by the agreement, which involves both sides rolling back contentious actions, it is <a href="https://www.benzinga.com/markets/macro-economic-events/25/06/45900295/this-is-another-band-aid-say-experts-questioning-long-term-viability-and-efficacy-of-us-china-trade-deal-china-always-had-this-trump-card">still pending approval</a> from President Donald Trump and Chinese counterpart Xi Jinping.
Derek Scissors, a senior fellow at the American Enterprise Institute, remarked that the deal is merely another "band aid." He further warned that China could easily reinstate the blockade on rare earths. Marc Busch, a professor of international business diplomacy at Georgetown University, added to the concerns, noting that China's rhetoric hasn't shifted, raising doubts regarding the sustainability of negotiations.
Despite the headwinds, the broader point is that the Trump administration, for all its tough talk, likely understands the consequences of unmitigated aggression. The president has previously <a href="https://www.benzinga.com/analyst-stock-ratings/analyst-color/25/06/45715677/tom-lee-bets-on-a-new-bull-market-as-trumps-tariff-retreat-fuels-taco-trade-amid-run-it-hot-optimism">issued stern warnings and later walked back</a> the magnitude of his policies. China being the world's second-largest economy, the White House can't afford to act imprudently.
On the other end, the Chinese economy isn't all rainbows and gummy bears either. When tensions first erupted, China was already dealing with serious issues, such as <a href="https://www.benzinga.com/markets/25/04/45033463/as-china-downplays-trump-tariffs-with-5-growth-target-top-economist-warns-of-90-chance-of-a-us-recession-amid-trade-war">deflation and a prolonged property crisis</a>. Both sides have reason to play ball and that ultimately may be good news for Applied Materials.
<h2 class="wp-block-heading">Statistical Backdrop Smiles Favorably On AMAT Stock</h2>
While narratives provide the context and color surrounding a particular asset or enterprise, they're not great at forecasting market behaviors. Storylines focus on the "why" of an investment. But when it comes to trading, participants of this discipline tend to focus on the "how" — how much, how fast and most importantly, how likely.
With options trading in particular, it's not enough to have confidence that AMAT stock will move in a certain direction. Depending on the specific strategy, the magnitude of movement is critical. At the same time, all options expire. Therefore, the speculated move must occur within the defined window. This makes probability the centerpiece of options market analysis.
Tackling the topic of probabilities isn't easy using traditional methodologies of fundamental and technical analysis. That's because both approaches suffer from the non-stationarity dilemma: the metric of comparison (such as share price or earnings) fluctuates temporally and contextually. Also, pattern-based technical analysis — while offering a visual representation of price behaviors — is not falsifiable.
To remedy this problem, traders can impose stationarity by converting pricing data into market breadth sequences; that is, sequences of accumulative and distributive sessions. Doing so creates a binary ecosystem, where demand profiles are assessed by a simple observation — it's either happening or it's not.
<figure class="wp-block-image size-large"><img loading="lazy" decoding="async" width="1024" height="576" src="https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/12151610/AMAT-stock-10wk-forecast-1024x576.jpg" alt="" class="wp-image-948180" srcset="https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/12151610/AMAT-stock-10wk-forecast-1024x576.jpg 1024w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/12151610/AMAT-stock-10wk-forecast-300x169.jpg 300w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/12151610/AMAT-stock-10wk-forecast-768x432.jpg 768w,https://editorial-assets.benzinga.com/wp-content/uploads/2025/06/12151610/AMAT-stock-10wk-forecast.jpg 1280w" sizes="(max-width: 1024px) 100vw, 1024px" /><figcaption class="wp-element-caption">Image by author</figcaption></figure>
Currently, AMAT stock is on course to print a "6-4-U" sequence: six up weeks, four down weeks, with a net positive trajectory across the 10-week period. In 56.67% of cases, the following week's price action results in upside, with a median return of 2.26%. Assuming that AMAT closes this Friday at $175, it could potentially rise to just under $179 in short order, perhaps a week or two.
Should the bulls maintain control of the market, historical trends suggest that AMAT stock could push toward the $181 level in the next three to four weeks.
<h2 class="wp-block-heading">An Optimistic But Sensible Trade For Applied Materials</h2>
Based on the market intelligence above, the multi-leg options strategy that arguably stands out the most is the 177.50/180 bull call spread expiring July 11. This transaction involves buying the $177.50 call and simultaneously selling the $180 call, for a net debit paid of $125. Should AMAT stock rise through the short strike price ($180) at expiration, the maximum reward is also $125, a payout of 100%.
Primarily, this trade is attractive because of the statistical response to the 6-4-U sequence. With the fundamentals also aligning positively, AMAT stock in theory should have enough fuel to trigger the short strike price at expiration.
Further, the 6-4-U represents a positive uptick in terms of sentiment regime. As a baseline, the chance that a long position will be profitable over any given week is 54%. With the aforementioned sequence, the bullish trader receives almost 3 percentage points of favorable odds.
Granted, it's not the biggest advantage. However, the advantage is still on the bulls' side, incentivizing a long-side debit strategy. As well, the political backdrop adds credibility to the argument.
The opinions and views expressed in this content are those of the individual author and do not necessarily reflect the views of Benzinga. Benzinga is not responsible for the accuracy or reliability of any information provided herein. This content is for informational purposes only and should not be misconstrued as investment advice or a recommendation to buy or sell any security. Readers are asked not to rely on the opinions or information herein, and encouraged to do their own due diligence before making investing decisions.
Read Next:
<ul class="wp-block-list">
<li><a href="https://www.benzinga.com/markets/options/25/06/45893665/mrvl-stock-trade-agreement-sleeper-options-opportunity">Options Corner: Why The Latest U.S.-China Trade Agreement Makes Marvell A Sleeper Opportunity</a></li>
</ul>
Photo: Shutterstock

Equities

Long Ideas

Options

AMAT

Options Corner: Diplomatic Progress Clears The Path For This Call Spread On Applied Materials

<a href="https://trumpstruth.org/statuses/31488">https://trumpstruth.org/statuses/31488</a>

President Trump Says We Remain Committed To A Diplomatic Resolution To Iran Nuclear Issue; My Entire Administration Has Been Directed To Negotiate With Iran; Iran First Must Completely Give Up Hopes Of Obtaining A Nuclear Weapon

Management

ONTO

Onto Innovation Appoints Brian Roberts As CFO, Effective As Of June 16, 2025

<a href="https://www.reuters.com/business/aerospace-defense/after-trump-feud-role-musks-spacex-golden-dome-missile-shield-question-2025-06-12/">https://www.reuters.com/business/aerospace-defense/after-trump-feud-role-musks-spacex-golden-dome-missile-shield-question-2025-06-12/</a>

'After Trump feud, role of Musk's SpaceX in Golden Dome missile shield in question'- Reuters Exclusive

IPOs

Press Releases

Sionna Therapeutics Prices Upsized Initial Public Offering

Sionna Therapeutics Announces Closing of $219.2 million Upsized Initial Public Offering, Including Full Exercise of Underwriters' Option to Purchase Additional Shares

Sionna Therapeutics to Present at the 45th Annual TD Cowen Health Care Conference

Sionna Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results

Health Care

Sionna Therapeutics to Present at The Citizens Life Sciences Conference 2025

Sionna Therapeutics Reports First Quarter 2025 Financial Results

Sionna Therapeutics to Present Preclinical Data During Oral Session at the 48th European Cystic Fibrosis Conference

Sionna Therapeutics to Present at the Goldman Sachs 46th Annual Global Healthcare Conference

Sionna Therapeutics Announces Positive Phase 1 Data for NBD1 Stabilizers SION-719 and SION-451 and Advances Both Programs in Clinical Development for Cystic Fibrosis

Sionna Therapeutics Announces Presentation of Preclinical Data that Demonstrate Proprietary Dual Combination Therapies Enable Full CFTR Correction in CFHBE Model

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