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Updated: Sep 26, 2026
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Oruka Therapeutics

NASDAQ:ORKA·Stock Analysis Report
Day Range
$84.00 - $86.49
Market Cap
5.69B
P/E Ratio
0.0000
Avg Value
$65.64
Year Range
$15.77 - $115.52
$84.46-$1.03 (-1.20%)
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General Information
Oruka Therapeutics Inc a clinical-stage biopharmaceutical company focused on developing novel monoclonal antibody therapeutics for psoriasis (PsO) and other inflammatory and immunology (I&I) indications.

Its programs are to treat and potentially modify disease by targeting mechanisms with efficacy and safety involved in disease pathology and the activity of pathogenic tissue-resident memory T cells (TRMs). Its program, ORKA-001, is designed to target the p19 subunit of interleukin-23 (IL-23p19) for the treatment of PsO. Its co-lead program, ORKA-002, is designed to target interleukin-17A and interleukin-17F (IL-17A/F) for the treatment of PsO, hidradenitis suppurativa (HS), psoriatic arthritis (PsA), and other conditions.

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Oruka Therapeutics (ORKA) Stock Graph
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How We Grade Oruka Therapeutics (ORKA)

We grade stocks based on past performance, their future growth potential, intrinsic value, dividend history, and overall financial health.

The chart below shows how we grade Oruka Therapeutics (ORKA) across the board compared to its closest peers.

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Benzinga Edge Rankings

Benzinga Edge stock rankings give you four critical scores to help you identify the strongest and weakest stocks to buy and sell.

Momentum measures a stock's relative strength based on its price movement patterns and volatility over multiple timeframes, ranked as a percentile against other stocks.

Stock Score Locked: Want to See it?
Benzinga Rankings give you vital metrics on any stock – anytime.
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Peer Ratings

See how Oruka Therapeutics compares to its peers in these key performance metrics from Benzinga Rankings.

Top Peers
Value
Quality
Growth
Momentum
Short
Medium
Long
TVTXTravere Therapeutics
N/A
N/A
N/A
97.82
GRALGRAIL
N/A
N/A
N/A
98.89
KNSAKiniksa Pharmaceuticals
20.61
N/A
92
96.66
SRRKScholar Rock Holding
N/A
N/A
N/A
73.38
Short: price trend over the last couple of months
Medium: price trend over the last couple of quarters
Long: price trend over the past year
Stock Score Locked: Want to See it?
Benzinga Rankings give you vital metrics on any stock – anytime.
6
Future Growth
Our estimate of future price growth is based on an aggregation of 9 analyst ratings over the past 3 months and their 12-month price targets.

Below, you can see that analysts are estimating a 12-month price target range of $120.00 - $200.00 with an average of $146.89

70.80%
Expected movement for Oruka Therapeutics (ORKA) over the next 12 months
Based on these rankings

Recent Ratings for Oruka Therapeutics (ORKA)

Wedbush
Date:
Sep 24, 2026
Action:
Reiterates
Prev. Target:
$165.00
New Target:
$165.00
HC Wainwright & Co.
Date:
Sep 24, 2026
Action:
Reiterates
Prev. Target:
$120.00
New Target:
$120.00
HC Wainwright & Co.
Date:
Sep 3, 2026
Action:
Reiterates
Prev. Target:
$120.00
New Target:
$120.00
Guggenheim
Date:
Aug 11, 2026
Action:
Reiterates
Prev. Target:
$200.00
New Target:
$200.00
Wedbush
Date:
Aug 11, 2026
Action:
Reiterates
Prev. Target:
$165.00
New Target:
$165.00
BTIG
Date:
Aug 11, 2026
Action:
Reiterates
Prev. Target:
$151.00
New Target:
$151.00
HC Wainwright & Co.
Date:
Aug 3, 2026
Action:
Reiterates
Prev. Target:
$120.00
New Target:
$120.00
BTIG
Date:
Jul 13, 2026
Action:
Reiterates
Prev. Target:
$151.00
New Target:
$151.00
UBS
Date:
Jul 1, 2026
Action:
Maintains
Prev. Target:
$100.00
New Target:
$130.00
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Past Performance
How has Oruka Therapeutics (ORKA) performed over the past 5 years?

The two main factors that we consider when analyzing past performance is overall return and volatility

Using these two metrics, we can determine if this stock gave its investors enough return for the risk that they took on by owning it. This is measured by the sharpe ratio, which has been used as a primary measure of risk/reward trade-off for almost 60 years.

This ratio can be interpreted as the amount of return an investor has received for the amount of risk that they took on by owning the stock over that timeframe.

Oruka Therapeutics (ORKA) sharpe ratio over the past 5 years is 0.7721 which is considered to be above average compared to the peer average of 0.4261