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Updated: Aug 17, 2026
LYEL Logo

Lyell Immunopharma

NASDAQ:LYEL·Stock Analysis Report
Day Range
$15.66 - $17.15
Market Cap
332.04M
P/E Ratio
0.0000
Avg Value
$27.78
Year Range
$10.56 - $45.00
$15.76-$0.03 (-0.19%)
1
General Information
Lyell Immunopharma Inc s a late-stage clinical cell therapy company advancing a pipeline of proprietary next-generation autologous chimeric antigen receptor (CAR) T-cell product candidates for patients with hematologic malignancies and solid tumors.

The Company's product candidate, rondecabtagene autoleucel (ronde-cel, also known as LYL314), is an autologous dual-targeting CD19/CD20 CAR T-cell therapy in development for large B-cell lymphoma (LBCL). The Company has recently acquired exclusive rights outside of mainland China, Hong Kong, Macau and Taiwan, to a novel guanylyl cyclase C (GCC)-targeted CAR T-cell product candidate in early clinical development for refractory metastatic colorectal cancer (mCRC) and other GCC-expressing cancers.

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Lyell Immunopharma (LYEL) Stock Graph
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How We Grade Lyell Immunopharma (LYEL)

We grade stocks based on past performance, their future growth potential, intrinsic value, dividend history, and overall financial health.

The chart below shows how we grade Lyell Immunopharma (LYEL) across the board compared to its closest peers.

4
Benzinga Edge Rankings

Benzinga Edge stock rankings give you four critical scores to help you identify the strongest and weakest stocks to buy and sell.

Momentum measures a stock's relative strength based on its price movement patterns and volatility over multiple timeframes, ranked as a percentile against other stocks.

Stock Score Locked: Want to See it?
Benzinga Rankings give you vital metrics on any stock – anytime.
5
Peer Ratings

See how Lyell Immunopharma compares to its peers in these key performance metrics from Benzinga Rankings.

Top Peers
Value
Quality
Growth
Momentum
Short
Medium
Long
AGENAgenus
29.79
N/A
N/A
98.5
IKTInhibikase Therapeutics
N/A
N/A
N/A
N/A
SABSSAB Biotherapeutics
N/A
N/A
N/A
86.53
IMRXImmuneering
N/A
N/A
N/A
80.79
Short: price trend over the last couple of months
Medium: price trend over the last couple of quarters
Long: price trend over the past year
Stock Score Locked: Want to See it?
Benzinga Rankings give you vital metrics on any stock – anytime.
6
Future Growth
Our estimate of future price growth is based on an aggregation of 5 analyst ratings over the past 3 months and their 12-month price targets.

Below, you can see that analysts are estimating a 12-month price target range of $34.00 - $45.00 with an average of $41.71

207.85%
Expected movement for Lyell Immunopharma (LYEL) over the next 12 months
Based on these rankings

Recent Ratings for Lyell Immunopharma (LYEL)

Citizens
Date:
Jun 15, 2026
Action:
Reiterates
Prev. Target:
$34.00
New Target:
$34.00
Needham
Date:
Jun 15, 2026
Action:
Reiterates
Prev. Target:
$44.00
New Target:
$44.00
HC Wainwright & Co.
Date:
Jun 9, 2026
Action:
Reiterates
Prev. Target:
$45.00
New Target:
$45.00
Needham
Date:
Jun 8, 2026
Action:
Reiterates
Prev. Target:
$44.00
New Target:
$44.00
HC Wainwright & Co.
Date:
Jun 3, 2026
Action:
Reiterates
Prev. Target:
$45.00
New Target:
$45.00
7
Financial Health
What is the current state of the company's financial situation?

We measure the health of a company based on how profitable they are and their ability to cover both their short-term and long-term debts. The key indicators that we use are the Operating Margin, Quick Ratio, and Debt-to-Equity ratio relative to the companies peers

Operational Margin -11,834.2500

The operating margin measures how much profit a company makes after it spends money on wages, materials or other administrative expenses but before interest and taxes. It is a good representation of how efficiently a company is able to generate profit from its core operations.

Quick Ratio 5.1196

The quick ratio measures how much of a company's debt, that is due in less than 1 year, can be covered using its cash equivalents, marketable securities, and money that is currently owed to them (accounts receivables).

A company with a quick ratio of less than 1.00 does not, in many cases, have the capital on hand to meet its short-term obligations if they were all due at once, while a quick ratio greater than one indicates the company has the financial resources to remain solvent in the short term.

Debt-to-Equity 0.3308

Debt-to-equity is calculated by dividing a company's total liabilities by its shareholders equity. It is a measure of the degree to which a company is financing its operations through debt versus wholly owned funds. Generally speaking, a D/E ratio below 1.0 would be seen as relatively safe, whereas ratios of 2.0 or higher would be considered risky.

The chart above shows Lyell Immunopharma (LYEL) operating margin, quick ratio, and debt-to-equity ratio compared to its peers. The black markers represent the peer averages for each ratio and the blue bars represent Lyell Immunopharma (LYEL) ratio values.
8
Past Performance
How has Lyell Immunopharma (LYEL) performed over the past 5 years?

The two main factors that we consider when analyzing past performance is overall return and volatility

Using these two metrics, we can determine if this stock gave its investors enough return for the risk that they took on by owning it. This is measured by the sharpe ratio, which has been used as a primary measure of risk/reward trade-off for almost 60 years.

This ratio can be interpreted as the amount of return an investor has received for the amount of risk that they took on by owning the stock over that timeframe.

Lyell Immunopharma (LYEL) sharpe ratio over the past 5 years is -0.1680 which is considered to be above average compared to the peer average of -0.3401

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Company Financials
INCOME STATEMENT
The income statement also known as the profit and loss statement, primarily focuses on the company's revenues and expenses during a particular period.

The main purpose of an income statement is to convey details of profitability and business activities. Below, is LYEL's income statement for the previous four years along with its trailing-twelve- month profit & loss.

FISCAL YEAR (BIL.)
2022 ($)
2023 ($)
2024 ($)
2025 ($)
TTM ($)
Total Revenue
0.08
0.00
0.00
0.00
0.00
Operating Revenue
0.08
0.00
0.00
0.00
0.00
Cost Of Revenue
Gross Profit
Operating Expense
0.27
0.25
0.22
0.20
0.19
Selling General And Administration
0.12
0.07
0.05
0.05
0.04
Research and Development
0.16
0.18
0.17
0.16
0.16
Operating Income
-0.19
-0.25
-0.22
-0.20
-0.19
Net Non-Operating Interest Income Expense
0.01
0.02
0.02
0.01
0.01
Other Income Expense
0.00
-0.01
-0.15
-0.09
-0.07
Other Non-Operating Income Expenses
0.00
0.00
0.00
-0.02
0.00
Pre-Tax Income
-0.18
-0.23
-0.34
-0.27
-0.25
Tax Provision
Net Income
-0.18
-0.23
-0.34
-0.27
-0.25
Net Income Common Stockholders
-0.18
-0.23
-0.34
-0.27
-0.25
Total Operating Income As Reported
-0.19
-0.25
-0.36
-0.27
-0.26
Total Expenses
0.27
0.25
0.22
0.20
0.19
Net Income From Continuing And Discontinued Operation
-0.18
-0.23
-0.34
-0.27
-0.25
Normalized Income
-0.18
-0.22
-0.19
-0.21
-0.18
Interest Income
0.01
0.02
0.02
0.01
0.01
Interest Expense
Net Interest Income
0.01
0.02
0.02
0.01
0.01
EBIT
-0.19
-0.25
-0.22
-0.20
-0.19
EBITDA
-0.17
-0.23
-0.20
-0.19
-0.18
Reconciled Cost Of Revenue
Reconciled Depreciation
0.02
0.02
0.02
0.01
0.01
Normalized EBITDA
-0.16
-0.21
-0.05
-0.12
-0.11
Tax Rate For Calcs
0.00
0.00
0.00
0.00
0.00
Tax Effect Of Unusual Items
0.00
0.00
0.00
0.00
0.00
BALANCE SHEET
The balance sheet is a snapshot of a companies financials during a particular period in time.

It breaks down what company owns (assets) and what a company owes (liabilities), in order to give investors an overview of its capital structure.

FISCAL YEAR (BIL.)
2022 ($)
2023 ($)
2024 ($)
2025 ($)
TTM ($)
Total Assets
0.94
0.75
0.49
0.34
0.31
Current Assets
0.65
0.55
0.38
0.26
0.21
Total Non-Current Assets
0.29
0.20
0.11
0.08
0.10
Total Liabilities Net Minority Interest
0.10
0.10
0.11
0.09
0.08
Current Liabilities
0.04
0.03
0.05
0.05
0.04
Other Non-Current Liabilities
0.00
0.00
0.00
0.00
0.00
Total Equity Gross Minority Interest
0.83
0.65
0.38
0.25
0.23
Stockholders Equity
Total Capitalization
0.83
0.65
0.38
0.25
0.23
Common Stock Equity
0.83
0.65
0.38
0.25
0.23
Net Tangible Assets
0.83
0.65
0.38
0.25
0.23
Working Capital
0.61
0.52
0.33
0.21
0.17
Invested Capital
0.83
0.65
0.38
0.25
0.23
Tangible Book Value
0.83
0.65
0.38
0.25
0.23
Total Debt
0.07
0.06
0.06
0.05
0.04
Net Debt
Share Issued
0.01
0.01
0.01
0.02
0.02
Ordinary Shares Number
0.01
0.01
0.01
0.02
0.02
CASH FLOW STATEMENTS
A companies statement of cash flows gives an investor a break down of the cash inflows and outflows from a companies operations and investment activities.
FISCAL YEAR (BIL.)
2022 ($)
2023 ($)
2024 ($)
2025 ($)
TTM ($)
Cash Flow from Continuing Operating Activities
-0.17
-0.16
-0.16
-0.15
-0.13
Net Income from Continuing Operations
-0.18
-0.23
-0.34
-0.27
-0.25
Depreciation and Amortization
0.02
0.02
0.02
0.01
0.01
Deferred Tax
Deferred Income Tax
Stock-Based Compensation
0.08
0.05
0.03
0.04
0.04
Other Non-Cash Items
-0.01
0.00
0.08
0.06
0.06
Change in Working Capital
-0.08
0.00
0.00
-0.01
0.01
Change in Receivables
Changes in Account Receivables
Change in Inventory
Change in Payables and Accrued Expense
0.00
0.00
0.00
-0.01
0.01
Change in Payable
0.00
0.00
0.00
0.00
0.00
Change in Account Payable
0.00
0.00
0.00
0.00
0.00
Change in Other Current Assets
Change in Other Current Liabilities
0.00
0.00
0.00
0.00
0.00
Change in Other Working Capital
-0.08
Cash Flow from Continuing Investing Activities
-0.01
0.18
0.12
0.05
0.00
Net PPE Purchase and Sale
-0.02
0.00
0.00
0.00
0.00
Net Business Purchase and Sale
Purchase of Business
Net Investment Purchase and Sale
0.01
0.19
0.15
0.10
0.05
Purchase of Investment
-0.39
-0.28
-0.20
Sale of Investment
0.42
0.66
0.55
0.37
0.25
Net Other Investing Changes
Financing Cash Flow
0.01
0.00
0.00
0.05
0.10
Cash Flow from Continuing Financing Activities
0.01
0.00
0.00
0.05
0.10
Net Issuance Payments of Debt
Net Long-Term Debt Issuance
Long-Term Debt Issuance
Long-Term Debt Payments
Net Short-Term Debt Issuance
Net Common Stock Issuance
Common Stock Issuance
Common Stock Payments
Cash Dividends Paid
Net Other Financing Charges
0.00
0.00
End Cash Position
0.67
0.77
0.47
0.41
0.35
Changes in Cash
-0.17
0.02
-0.04
-0.05
-0.03
Beginning Cash Position
0.84
0.74
0.51
0.45
0.38
Capital Expenditure
-0.02
0.00
0.00
0.00
0.00
Issuance of Capital Stock
Issuance of Debt
Repayment of Debt
Repurchase of Capital Stock
Free Cash Flow
-0.19
-0.17
-0.16
-0.15
-0.13