Últimas noticias sobre Edesa Biotech (NASDAQ:EDSA) Bolsa

Edesa Biotech

Edesa Biotech Inc is a biotechnology company focused on inflammatory and immune-related diseases. It is involved in exploring novel ways to treat these diseases, including alternatives to topical steroids, which can have side effects. The company's product candidate, EB06, is an anti-CXCL10 monoclonal antibody candidate and is being developed as a therapy for vitiligo, a common autoimmune disorder that causes the skin to lose its color in patches. The other drug candidates in its product pipeline include EB05, EB07, and EB01 which are in their different phases of development.

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EDSA

El Índice de Precios al Productor en EE. UU. subió un 3,5% en enero, superando las previsiones. ¿Cómo reaccionaron los mercados?

Acciones de EE. UU. reaccionan al alza tras el aumento del PPI: ¿qué esperar ahora?

Edesa Biotech Inc

ADMA Biologics Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ADMA#NASDAQ">ADMA</a>) shares are trading higher Monday following the Food and Drug Administration&#8216;s (FDA) approval of its <a href="https://www.benzinga.com//node/45034986">yield enhancement process.</a>
What To Know: ADMA's yield enhancement process has demonstrated the ability to increase production yields by approximately 20% from the same starting plasma volume.
&#8220;This approval represents a pivotal milestone for ADMA, unlocking the opportunity for meaningful acceleration in our revenue and earnings trajectory beginning in late 2025 and accelerating further into 2026 and beyond,&#8221; said Adam Grossman, President and CEO of ADMA.
Grossman added that the company is focused on advancing its internal Research and Development platform to further optimize production capabilities and develop new pipeline programs, most notably SG-001, an early-stage antibody therapy targeting S. pneumoniae.
What Else: The company is expected to report first-quarter earnings on May 12th. Analysts&#8217; estimate earnings per share of 16 cents and revenue of $116.40 million.
Related Link: <a href="https://www.benzinga.com/news/25/04/45046313/nuvve-expands-beyond-evs-with-bold-bitcoin-crypto-investment-arm">Nuvve Expands Beyond EVs With Bold Bitcoin, Crypto Investment Arm</a>
ADMA Price Action: At the time of publication, ADMA share are trading 9.79% higher at $24.00, according to data from <a href="https://www.benzinga.com/pro/">Benzinga Pro.</a>
Image: via Shutterstock

Movers

ADMA

What's Going On With ADMA Stock Monday?

HC Wainwright &amp; Co. analyst Robert Burns maintains Caribou Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CRBU#NASDAQ">CRBU</a>) with a Buy and lowers the price target from $9 to $3.

Price Target

Analyst Ratings

CRBU

HC Wainwright & Co. Maintains Buy on Caribou Biosciences, Lowers Price Target to $3

UroGen Pharma Ltd.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/URGN#NASDAQ">URGN</a>) on Sunday highlighted a duration of response of nearly four years from a long-term follow-up study with Jelmyto&nbsp;(mitomycin) <a target="_blank" href="https://www.benzinga.com/general/health-care" rel="noreferrer noopener">for pyelocalyceal solution</a>.
The U.S. Food And Drug Administration approved Jelmyto in 2020 for low-grade upper tract urothelial cancer (LG-UTUC) in adults.
Among patients from the OLYMPUS trial who achieved a complete response after primary chemoablation with Jelmyto (n = 41), the median duration of response was 47.8 months, regardless of whether their cancer was new onset or recurrent (median <a href="https://www.benzinga.com/pressreleases/25/04/b45029814/olympus-long-term-follow-up-study-reports-nearly-four-year-duration-of-response-in-subset-of-patie" target="_blank" rel="noopener">follow-up,</a><a href="https://www.benzinga.com/pressreleases/25/04/b45029814/olympus-long-term-follow-up-study-reports-nearly-four-year-duration-of-response-in-subset-of-patie" target="_blank" rel="noreferrer noopener"> 28.1 months)</a>.
Of these patients, 21 had new-onset UTUC, and 20 had recurrent UTUC at baseline. There were no significant differences in durability between the groups, with eight patients in each group experiencing recurrence or death not due to treatment.
20 patients entered long-term follow-up.
To further explore Jelmyto&#8217;s potential in treating patients with LG-UTUC, investigators are now enrolling participants in the Jelmyto uTRACT Registry to gather longitudinal real-world usage data. As of April 2025, 22 sites have been activated and 251 patients have been enrolled.
On Sunday, UroGen Pharma also announced new data from the OPTIMA II Phase 2b study of UGN‑102 (mitomycin) for an intravesical solution.
The data demonstrated a clinically meaningful two-year duration of response (24.2 months).
UGN-102 is UroGen&#8217;s sustained-release formulation of mitomycin, being developed for recurrent low-grade, intermediate-risk, non-muscle-invasive bladder cancer (LG-IR-NMIBC).
Among the 41 patients achieving a complete response (CR) at three months, 25 remained in CR at 12 months, and 17 of these patients entered long-term follow-up.
The median duration of response for the 41 patients who achieved CR was 24.2 months, with a median follow-up time of 33.6 months. Twenty patients (48.8%) experienced recurrence of low-grade disease.
One patient progressed to a high-grade disease, and one patient died due to a cardiac disorder. Five patients remained disease-free at the time of the four-year data analysis.
UroGen completed the submission of the UGN-102 rolling new drug application (NDA) to the FDA for UGN-102 in August 2024. The FDA accepted the NDA for UGN-102 with a Prescription Drug User Free Act (PDUFA) <a target="_blank" href="https://www.benzinga.com/pressreleases/25/04/b45029409/new-long-term-follow-up-data-from-optima-ii-study-of-ugn-102-demonstrates-median-duration-of-respo" rel="noreferrer noopener">goal date of June 13, 2025</a>.
UroGen Pharma also shared an updated 18-month DOR of 80.6% from the Phase 3 ENVISION trial of UGN-102 (mitomycin) for the intravesical solution, an investigational treatment for <a href="https://www.benzinga.com/pressreleases/25/04/b45028100/urogen-announces-updated-18-month-duration-of-response-dor-of-80-6-from-the-phase-3-envision-trial" target="_blank" rel="noreferrer noopener">recurrent LG-IR-NMIBC</a>.
On Friday, UroGen Pharma shared safety data from the Phase 1 dose-escalation study for UGN-301 (zalifrelimab) intravesical solution for recurrent non-muscle <a target="_blank" href="https://www.benzinga.com/pressreleases/25/04/b45027276/urogen-pharma-announces-encouraging-results-from-a-phase-1-dose-escalation-study-evaluating-ugn-30" rel="noreferrer noopener">invasive bladder cancer</a>.
The study included up to 30 patients per arm and aimed to assess safety and determine the recommended Phase 2 dose of UGN-301 as monotherapy and in combination with other agents.
In the monotherapy arm, dose escalation continued to the maximum feasible dose. No dose-limiting toxicities or treatment-emergent adverse events leading to treatment discontinuation were observed.
Among evaluable patients who received UGN-301, 46% of those with Ta/T1 disease and 33% with carcinoma in situ (CIS) ± Ta/T1 disease were recurrence-free or had achieved a complete response at week 12.
At the 15-month disease assessment, 60% of patients with Ta/T1 disease treated with 300 mg remained recurrence-free, including one with high-grade T1 disease.
In the 500 mg cohort, 25% of patients with CIS disease and 33% of patients with Ta/T1 disease remained disease-free at six months; both are still active participants in the study.
D.Boral Capital analyst Jason Kolbert writes, &#8220;These data position UGN-301 as a promising candidate for a population in urgent need of more localized, immunomodulatory therapies&#8230;&#8221;
Price Action: URGN stock is up 7.65% at $10.63&nbsp;at the last check Monday.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/news/earnings/25/04/45041333/roper-lifts-2025-guidance-after-solid-q1-ceo-sees-growth-ahead-despite-economic-uncertainty" target="_blank" rel="noreferrer noopener">Roper Lifts 2025 Guidance After Solid Q1, CEO Sees Growth Ahead Despite Economic Uncertainty</a></li>
</ul>
Photo: Shutterstock

Analyst Color

Biotech

Health Care

General

URGN

UroGen Pharma Touts Four-Year Response With Urothelial Cancer Drug Study, Highlights Potential For Bladder Cancer Candidates

Oppenheimer analyst Timothy Horan rated Charter Communications Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CHTR#NASDAQ">CHTR</a>) <a href="https://www.benzinga.com/quote/CHTR/analyst-ratings" target="_blank" rel="noreferrer noopener">as Perform on</a> Monday.
Charter is the nation&#8217;s second-largest cable provider. In terms of network quality and speeds, the company holds a major competitive advantage over wireline providers.
Also Read: <a target="_blank" href="https://www.benzinga.com/news/earnings/25/04/45007666/charter-loses-internet-and-tv-subscribers-but-beats-rivals-with-strong-mobile-line-gains" rel="noreferrer noopener">Charter Loses Internet And TV Subscribers But Beats Rivals With Strong Mobile Line Gains</a>
Horan noted its ability to generate consistently high cash flow from its businesses, which gives it added flexibility to adapt to industry trends despite its large size.
Charter&#8217;s revenue grew 0.4% versus Horan&#8217;s flat estimate, a $70 million beat. EBITDA was up 5% on a 180bps expansion in EBITDA margins to 42%, an 80bps beat, but it would have been in line with normalizing for a one-time $75 million other expense benefit.
Subscriber losses have improved off a very difficult 2024 due to the expiration of ACP and hurricanes Milton and Helene, and now improved bundled offers.
Its video offering now has OTT packages worth $80 per month bundled in and attractive promotional wireless/broadband prices which began in the fourth-quarter of 2024.
The analyst noted this as a negative for the overall industry, but price increases on the base continue to grow, and they are upselling many additional services.
The company&#8217;s introductory promotional pricing for broadband is $40 per month, but Horan estimates its base is paying $80 per month and can move to a wireless carrier for permanent pricing of $50. Positively, using a crude metric of revenue per residential broadband subscriber, Charter is at $130 per month versus Comcast Corp (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CMCSA#NASDAQ">CMCSA</a>) at $170. Both are at $70 for broadband, reported ARPU.
Charter lost 55K broadband subscribers versus -72K in the first quarter of 2024, and Horan noted a normalized ACP total loss of ~150K in fiscal 2024. Video declined 167K versus -392K in the first quarter of 2024.
ACP is now behind the company, and new promos are helping; however, the analyst continues to see challenging competition with lower-priced fixed and mobile hotspot wireless, fiber and OTT video.
Charter has resumed stock repurchases after the Liberty Broadband acquisition vote.
Leverage has declined to 4.1x and will head to 4.25x gradually.
Positively, Horan does not expect Charter to grow EBITDA by ~2% per year. With stock buybacks and lower capex, free cash flow per share can increase 4x by 2030 to ~$100.
Charter reiterated its fiscal 2025 capex of ~$12 billion, declining to $8 billion in 2028.
Cash taxes of $1.6-2.0 billion, implying a ~15% Y/Y increase, but $1 billion of this in the second quarter.
Horan tweaked subscriber and financial estimates on the early effectiveness of the new go-to-market. The analyst reiterated that Charter looks attractive on a long-term free cash flow per-share basis following the completion of its network evolution in two years and major stock buybacks at a ~27% 2030 free cash flow yield.
Horan projected second-quarter revenue of $13.73 billion and EPS of $9.07.
CHTR Price Action: Charter Communications stock is up 0.97% to $377.29 at the last check on Monday.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/25/04/45023162/comcast-faces-analyst-concerns-over-broadband-losses-despite-solid-revenue-and-peacock-gains" target="_blank" rel="noreferrer noopener">Comcast Faces Analyst Concerns Over Broadband Losses Despite Revenue And Peacock Gains</a></li>
</ul>
Photo: Shutterstock

CHTR

CMCSA

Charter's Strong Network, New Bundles Drive Analyst Optimism For Long-Term Growth

Goldman Sachs analyst Jordan Alliger maintains Saia (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SAIA#NASDAQ">SAIA</a>) with a Neutral and lowers the price target from $485 to $387.

SAIA

Goldman Sachs Maintains Neutral on Saia, Lowers Price Target to $387

HC Wainwright &amp; Co. analyst Raghuram Selvaraju maintains Balchem (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BCPC#NASDAQ">BCPC</a>) with a Buy and lowers the price target from $190 to $180.

BCPC

HC Wainwright & Co. Maintains Buy on Balchem, Lowers Price Target to $180

Goldman Sachs analyst Mark Delaney maintains QuantumScape (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/QS#NYSE">QS</a>) with a Sell and lowers the price target from $3 to $2.5.

Goldman Sachs Maintains Sell on QuantumScape, Lowers Price Target to $2.5

Boeing Company (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BA#NYSE">BA</a>) shares are trading higher on Monday after Bernstein upgraded the stock from a Market Perform rating to a Outperform rating and raised its price target <a href="https://www.benzinga.com//node/45044269">from $181 to $218.</a>
What To Know: In the note, analyst Douglas Harned said &#8220;all looked good&#8221; with Boeing until the Alaska Airlines door accident in January 2024, but the company is now making progress on its prior growth trajectory.
The analyst expects Boeing is on track to produce 38 737 MAX planes per month by July, in line with CEO Kelly Ortberg&#8216;s comments during the company's latest earnings call. Ortberg said the company might start producing 42 737 MAX planes per month by the end of the year, if the Federal Aviation Administration signs off on it. 
The company plans to ramp up production further in the future, increasing to 47, 52 and then 57 planes per month at six-month intervals. However, the analyst expects these increases to occur at nine-month intervals instead.
Additionally, Boeing expects to reach production of seven 787 planes per month by the end of 2025, exceeding analysts' expectations. The quality and heat exchanger issues appear to be resolved as well.
The analyst noted issues with Boeing&#8217;s Defense and Space Systems (BDS), but said the business may be turning a corner following a major contract win and improved financial performance.
Harned said, &#8220;With the win of Next-Generation Air Dominance, now the F-47, Boeing will be back into major military aircraft development programs. Boeing also is in the running versus Northrop Grumman for the F/A-XX competition (replacement for F/A-18E/F), which could be announced within days. This will allow utilization of the company's St. Louis site and should attract substantial engineering talent, which would be beneficial for Boeing more broadly.&#8221;
See Also: <a href="https://www.benzinga.com/news/earnings/earnings-misses/25/04/45045374/saias-q1-shocked-even-the-bears-analyst-slashes-price-target-compares-fundamentals-with-peers">Saia&#8217;s Q1 &#8216;Shocked Even The Bears&#8217;: Analyst Slashes Price Target, Compares Fundamentals With Peers</a>
BA Price Action: At the time of writing, Boeing stock is trading 1.89% higher at $181.32, according to data from <a href="https://www.benzinga.com/pro/">Benzinga Pro.</a>
Image: via Shutterstock

Boeing Stock Jumps On Bernstein Upgrade: Is The Company Back On Track?

Needham analyst Ami Fadia maintains Blueprint Medicines (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BPMC#NASDAQ">BPMC</a>) with a Buy and lowers the price target from $133 to $130.

BPMC

Needham Maintains Buy on Blueprint Medicines, Lowers Price Target to $130

Goldman Sachs analyst Duffy Fischer maintains LyondellBasell Industries (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LYB#NYSE">LYB</a>) with a Sell and lowers the price target from $81 to $65.

Goldman Sachs Maintains Sell on LyondellBasell Industries, Lowers Price Target to $65

90% of patients achieved high grade disease-free status at any time point with NDV-01, demonstrating strong proof-of-concept for sustained-release "GEM/DOCE" formulation&#x2A;
NDV-01 showed promising clinical activity in BCG-naïve and BCG-unresponsive patients, with favorable overall tolerability
Data to be reviewed at <a href="https://www.globenewswire.com/Tracker?data=N5KaNHiqGvYpAmX4yqdngx2XwtqKmKJxVdc03Zm5LpplNNj57qCBPBjNPMMnvhi4CFqUDLhWdfavHZSSj1w3M9sZzHWLm4_kXzYR8KhmLqQxqoxB9H2dqm5GUEoVj4DK">Investor Event</a> on April 28, 2025 at 4:30 PM ET
CORAL GABLES, Fla., April 28, 2025 (GLOBE NEWSWIRE) -- Relmada Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RLMD#NASDAQ">RLMD</a>, "Relmada", "the Company"))), a clinical-stage biotechnology company, today announced that positive initial data from the Phase 2 study of NDV-01 showed that 90% of patients achieved high-grade disease-free status at any time point following treatment, demonstrating strong clinical activity and supporting further development of NDV-01 for the treatment of non-muscle invasive bladder cancer (NMIBC). The data were presented today at the American Urology Association 2025 (AUA2025) Annual Meeting with a data cutoff date of April 20, 2025.

RLMD

Relmada Therapeutics: Initial Data From Phase 2 Study Of NDV-01 Shows Strong Clinical Activity In BCG-Naïve And BCG-Unresponsive Patients

WIIM

APLD

BITF

BTBT

BTCT

BTDR

CIFR

CLSK

COIN

Core Scientific, Inc. - Class A Common Stock

CORZ

HIVE

IREN

MARA

MSTR

RIOT

WULF

Shares of crypto-related companies are trading lower amid volatility in the price of Bitcoin.

Goldman Sachs analyst Duffy Fischer maintains Element Solutions (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ESI#NYSE">ESI</a>) with a Neutral and lowers the price target from $30 to $24.

Goldman Sachs Maintains Neutral on Element Solutions, Lowers Price Target to $24

HC Wainwright &amp; Co. analyst Douglas Tsao reiterates Rezolute (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RZLT#NASDAQ">RZLT</a>) with a Buy and maintains $14 price target.

Reiteration

RZLT

HC Wainwright & Co. Reiterates Buy on Rezolute, Maintains $14 Price Target

<a href="https://www.youtube.com/watch?v=YDnd7lGC9F4">https://www.youtube.com/watch?v=YDnd7lGC9F4</a>

White House Press Sec. Karoline Leavitt Says Trump Wants Tax Cuts In This Reconciliation Package

The Dallas Fed released its&nbsp;April Texas Manufacturing Outlook Survey&nbsp;(TMOS) on Monday. Perceptions of broader business conditions continued to worsen notably.
The general business activity index fell 20 points to -35.8, its lowest reading since May 2020.
The company outlook index also retreated to a post-pandemic low of -28.3, while the outlook uncertainty index climbed 11 points to 47.1.
The production index, which <a target="_blank" href="https://www.dallasfed.org/research/surveys/tmos/2025/2504" rel="noreferrer noopener">measures</a> manufacturing health, mainly remained the same at 5.1, indicating modest growth.
Also Read: <a href="https://www.benzinga.com/news/global/25/04/45017240/covid-like-shortages-empty-shelves-expected-thanks-to-trump-tariffs-experts-say" target="_blank" rel="noreferrer noopener">&#8216;COVID-Like&#8217; Shortages, Empty Shelves Expected Thanks To Trump Tariffs, Experts Say</a>
The new orders index dropped sharply by 20 points to -20.0. The capacity utilization index also dipped slightly to -3.8, and the shipments index turned negative for the first time this year, falling into negative territory for the first time this year to -5.5 from 6.1.
The employment index remained steady at -3.9, with 9% of companies reporting hiring and 13% reporting layoffs. The hours worked index fell to -6.4 from -2.9, suggesting shorter workweeks.
Price pressures grew stronger in April. The raw materials prices index jumped 11 points to 48.4, the highest since mid-2022. The finished goods prices index also rose by nine points to 14.9, above the average.
Wage growth stayed steady, with the wages and benefits index holding at 14.3, slightly below its average.
Expectations for future manufacturing activity were mixed. The future production index remained positive but fell 13 points to 14.8. Meanwhile, the future general business activity index dropped further into negative territory at -15.2. Most other future activity measures stayed positive but weakened compared to past averages.
In April, a Wedbush analyst wrote that Trump&#8217;s tariff disaster has been weighing heavily on the stock market, creating&nbsp;<a target="_blank" href="https://www.benzinga.com/25/04/44772840/analysts-warn-of-choppy-tech-outlook-despite-inflation-relief" rel="noreferrer noopener">uncertainty and dragging down prices</a>.
Survey respondents in chemical manufacturing commented, &#8220;Tariff uncertainty and actual impact is likely to be significant for the business and ongoing projects.&#8221;
&#8220;&#8230;We expect to see roughly a 10–15 percent decline in sales in May. We believe that this is largely due to uncertainty in our customer base driven by the tariff situation and potential knock-on effects to the general economy,&#8221; commented Computer and electronic product manufacturing responders.
Responders from Food manufacturing said tariffs and uncertainty are disrupting supply chains and making it difficult to plan investments.
It&#8217;s still unclear how tariffs will affect the overall economy. The sector does not import or export much (other than spices), so the proposed tariffs won&#8217;t directly hit them.
However, they are still concerned about rising labor costs caused by the trade war and immigration issues.
In a&nbsp;new poll&nbsp;by The Associated Press-NORC Center for Public Affairs Research, roughly three-quarters of adults <a target="_blank" href="https://www.benzinga.com/topic/tariffs" rel="noreferrer noopener">predict that tariffs</a> will drive up consumer prices, while about six in ten disapprove of the president&#8217;s handling of economic and trade matters.
61% of respondents said they are troubled by soaring grocery bills, while about half voiced anxiety about an impending economic downturn and the <a target="_blank" href="https://www.benzinga.com/markets/equities/25/04/45027881/trumps-approval-plummets-as-tariffs-bite-americans-expect-skyrocketing-prices-and-shrinking-wallets" rel="noreferrer noopener">affordability of major purchases</a>.
In April, President Trump announced a 90-day pause on tariffs for countries that have not retaliated&nbsp;against U.S. trade measures. The news ignited a broad risk-on rally, catapulting major indices to multi-month highs and <a target="_blank" href="https://www.benzinga.com/25/04/44724763/pharma-industry-faces-jitters-as-trump-hints-at-historic-tariffs-bofa-outlines-probable-timeline" rel="noreferrer noopener">sending volatility plunging</a>.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/markets/equities/25/04/45037102/walmart-home-depot-target-push-chinese-suppliers-to-resume-shipments-agree-to-absorb-tariffs-report" target="_blank" rel="noreferrer noopener">Walmart, Home Depot, Target Push Chinese Suppliers To Resume Shipments, Agree To Absorb Tariffs: Report</a></li>
</ul>
Image via Shutterstock

Government

Dallas Fed Flags Deepening Factory Gloom: Is Texas Warning Of Something Bigger?

Goldman Sachs analyst Duffy Fischer maintains Eastman Chemical (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EMN#NYSE">EMN</a>) with a Neutral and lowers the price target from $112 to $87.

Goldman Sachs Maintains Neutral on Eastman Chemical, Lowers Price Target to $87

HC Wainwright &amp; Co. analyst Andrew Fein reiterates ImmunityBio (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/IBRX#NASDAQ">IBRX</a>) with a Buy and maintains $8 price target.

IBRX

HC Wainwright & Co. Reiterates Buy on ImmunityBio, Maintains $8 Price Target

HC Wainwright &amp; Co. analyst Joseph Pantginis maintains Krystal Biotech (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/KRYS#NASDAQ">KRYS</a>) with a Buy and raises the price target from $221 to $240.

KRYS

HC Wainwright & Co. Maintains Buy on Krystal Biotech, Raises Price Target to $240

This whale alert can help traders discover the next big trading opportunities.
Whales are entities with large sums of money and we track their transactions here at Benzinga on our options activity scanner.
Traders will search for circumstances when the market estimation of an option diverges heavily from its normal worth. High amounts of trading activity could push option prices to exaggerated or underestimated levels. 
Here's the list of options activity happening in today's session: 
<table>
<thead>
<tr>
<th>Symbol</th>
<th>PUT/CALL</th>
<th>Trade Type</th>
<th>Sentiment</th>
<th>Exp. Date</th>
<th>Strike Price</th>
<th>Total Trade Price</th>
<th>Open Interest</th>
<th>Volume</th>
</tr>
</thead>
<tbody>
<tr>
<td>PFE</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>05/02/25</td>
<td>$22.00</td>
<td>$44.8K</td>
<td>10.4K</td>
<td>9.6K</td>
</tr>
<tr>
<td>MRK</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>01/15/27</td>
<td>$80.00</td>
<td>$29.2K</td>
<td>424</td>
<td>839</td>
</tr>
<tr>
<td>CVS</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>06/20/25</td>
<td>$60.00</td>
<td>$30.9K</td>
<td>8.4K</td>
<td>636</td>
</tr>
<tr>
<td>SMMT</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>08/15/25</td>
<td>$25.00</td>
<td>$34.2K</td>
<td>60</td>
<td>361</td>
</tr>
<tr>
<td>EW</td>
<td>PUT</td>
<td>TRADE</td>
<td>BULLISH</td>
<td>08/15/25</td>
<td>$72.50</td>
<td>$116.2K</td>
<td>52</td>
<td>350</td>
</tr>
<tr>
<td>NVO</td>
<td>CALL</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>05/16/25</td>
<td>$66.00</td>
<td>$46.1K</td>
<td>367</td>
<td>320</td>
</tr>
<tr>
<td>ALGN</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BEARISH</td>
<td>05/02/25</td>
<td>$157.50</td>
<td>$60.1K</td>
<td>4</td>
<td>294</td>
</tr>
<tr>
<td>LLY</td>
<td>CALL</td>
<td>TRADE</td>
<td>BEARISH</td>
<td>06/20/25</td>
<td>$880.00</td>
<td>$43.9K</td>
<td>2.3K</td>
<td>106</td>
</tr>
<tr>
<td>GEHC</td>
<td>PUT</td>
<td>SWEEP</td>
<td>BULLISH</td>
<td>05/16/25</td>
<td>$62.00</td>
<td>$27.6K</td>
<td>5</td>
<td>10</td>
</tr>
</tbody>
</table>

<h2>Explanation</h2>
These bullet-by-bullet explanations have been constructed using the accompanying table. 
• For PFE (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PFE#NYSE">PFE</a>), we notice a put option sweep that happens to be bearish, expiring in 4 day(s) on May 2, 2025. This event was a transfer of 2800 contract(s) at a $22.00 strike. This particular put needed to be split into 6 different trades to become filled. The total cost received by the writing party (or parties) was $44.8K, with a price of $16.0 per contract. There were 10427 open contracts at this strike prior to today, and today 9611 contract(s) were bought and sold. 
• For MRK (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MRK#NYSE">MRK</a>), we notice a call option trade that happens to be bearish, expiring in 627 day(s) on January 15, 2027. This event was a transfer of 20 contract(s) at a $80.00 strike. The total cost received by the writing party (or parties) was $29.2K, with a price of $1460.0 per contract. There were 424 open contracts at this strike prior to today, and today 839 contract(s) were bought and sold. 
• Regarding CVS (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CVS#NYSE">CVS</a>), we observe a put option sweep with bearish sentiment. It expires in 53 day(s) on June 20, 2025. Parties traded 183 contract(s) at a $60.00 strike. This particular put needed to be split into 3 different trades to become filled. The total cost received by the writing party (or parties) was $30.9K, with a price of $169.0 per contract. There were 8483 open contracts at this strike prior to today, and today 636 contract(s) were bought and sold. 
• For SMMT (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SMMT#NASDAQ">SMMT</a>), we notice a call option trade that happens to be bearish, expiring in 109 day(s) on August 15, 2025. This event was a transfer of 59 contract(s) at a $25.00 strike. The total cost received by the writing party (or parties) was $34.2K, with a price of $580.0 per contract. There were 60 open contracts at this strike prior to today, and today 361 contract(s) were bought and sold. 
• Regarding EW (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EW#NYSE">EW</a>), we observe a put option trade with bullish sentiment. It expires in 109 day(s) on August 15, 2025. Parties traded 350 contract(s) at a $72.50 strike. The total cost received by the writing party (or parties) was $116.2K, with a price of $332.0 per contract. There were 52 open contracts at this strike prior to today, and today 350 contract(s) were bought and sold. 
• Regarding NVO (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>), we observe a call option sweep with bullish sentiment. It expires in 18 day(s) on May 16, 2025. Parties traded 278 contract(s) at a $66.00 strike. This particular call needed to be split into 29 different trades to become filled. The total cost received by the writing party (or parties) was $46.1K, with a price of $166.0 per contract. There were 367 open contracts at this strike prior to today, and today 320 contract(s) were bought and sold. 
• Regarding ALGN (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ALGN#NASDAQ">ALGN</a>), we observe a put option sweep with bearish sentiment. It expires in 4 day(s) on May 2, 2025. Parties traded 204 contract(s) at a $157.50 strike. This particular put needed to be split into 33 different trades to become filled. The total cost received by the writing party (or parties) was $60.1K, with a price of $295.0 per contract. There were 4 open contracts at this strike prior to today, and today 294 contract(s) were bought and sold. 
• For LLY (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/LLY#NYSE">LLY</a>), we notice a call option trade that happens to be bearish, expiring in 53 day(s) on June 20, 2025. This event was a transfer of 10 contract(s) at a $880.00 strike. The total cost received by the writing party (or parties) was $43.9K, with a price of $4395.0 per contract. There were 2310 open contracts at this strike prior to today, and today 106 contract(s) were bought and sold. 
• Regarding GEHC (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GEHC#NASDAQ">GEHC</a>), we observe a put option sweep with bullish sentiment. It expires in 18 day(s) on May 16, 2025. Parties traded 240 contract(s) at a $62.00 strike. This particular put needed to be split into 6 different trades to become filled. The total cost received by the writing party (or parties) was $27.6K, with a price of $115.0 per contract. There were 5 open contracts at this strike prior to today, and today 10 contract(s) were bought and sold. 
Options Alert Terminology 
 - Call Contracts: The right to buy shares as indicated in the contract. 
 - Put Contracts: The right to sell shares as indicated in the contract. 
 - Expiration Date: When the contract expires. One must act on the contract by this date if one wants to use it. 
 - Premium/Option Price: The price of the contract. 
For more information, visit our <a href="https://pro.benzinga.com/blog/how-to-understand-option-alerts/">Guide to Understanding Options Alerts</a> or read <a href="https://www.benzinga.com/markets/options">more news on unusual options activity</a>. 
This article was generated by Benzinga's automated content engine and reviewed by an editor.

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